2018-2020 Flashcards
How many g of Na is recommended per day?
Age 1-4: 1500
Age 5+: 2300
Name 4 health risks of climate change
Heat and cold related morbidity and mortality
Natural hazards and extreme weather events
Increasing air pollution
Contaminated water sources
Infection risks associated with insects, ticks, and rodents
Stratospheric ozone depletion (worse up North with thinner ozone layer)
Why are children at higher risk of climate related health effects?
They have longer life time exposure and metabolize more per kilo
What children are at higher risk for climate related health risks?
Low SES
Indigineous
Chronic disease
What health concerns occurs occur in natural health hazards and weather events?
Injury and death Displaced from home Overcrowding Mental health impacts Food or water shortage Interruption to health care and education
What health complications occur due to ozone layer depletion?
Increased UV exposure
More skin cancer and cataracts and immune system compromise
How can pediatricians prevent climate change health complications?
Advocate for government to act against climate change
Volunteer on disaster planning committees
Recommending trainee climate change teaching
Role model environmental sustainability
5 ways to approach vaccine hesitancy in the community
Detect and address vaccine hesitant group
Educate health care providers on immunization best practices
Evidence based strategies to improve uptake
Educate children, youth, and adults on importance of immunization
Work collaboratively
Name 4 EBM strategies to increase vaccine uptake
Target underimmunized groups Make vaccine services convenient and accessible Engage community leaders (religious etc) Remind patients by text, mail, etc. Ensure uniformity across Canada Minimize pain Mandates or incentivized vaccines Build trust in immunization program
How to approach vaccine hesitancy in your clinic?
Don’t discharge anti vaccer from clinic
Presumptive approach and motivational interviewing
Effective clear language to explain vaccines
Manage immunization pain
Reinforce importance in community protection
Do you need neuropsych or psychology assessment to diagnose ADHD?
No
Only if complex ADHD with comorbidities or hard to diagnose
How should you manage suspecting ADHD in toddlers?
Parents should go to parenting class to teach them developmentally appropriate expectations of toddlers
Risk factors for ADHD (4)
Family history Epilepsy Hypoxic ischemic brain injury Traumatic brain injury In utero alcohol or tobacco exposure Low birth weight Intellectual disability Autism Prematurity (inattentive type only) Environmental toxins Central auditory processing d/o Fragile X Turner syndrome 22q11 Tuberous sclerosis NF1
Adverse outcomes of ADHD (4)
Poor education outcomes Poor relationships More MVA More accidental injuries More substance abuse
Do stimulants worsen tics?
Sometimes better and sometimes worse and sometimes no change. Don’t stop meds just change dose.
Ways to help diagnose ADHD (4)
Questionnaires
Mutliple clinic visits
Evaluate for comorbid d/o
Review report cards
Neurological and dysmorphology physical exam
Full history including prenatal
Ask about attachment, temperament, regulation
What makes ADHD more likely to persist into adulthood? (3)
Inattentive/hyperactive combined
More severe
Comorbid depression
More than 3 DSM d/o
Parental anxiety
Parental antisocial personality disorder
Intellectual disorder (also decreased med response especially when IQ under 50)
DSM V Criteria (5)
- Symptoms are severe and persistent since under 12 years old and for more than 6 mo
- Symptoms impair daily functioning in some way
- Need to have a reason for why there is discrepancy in symptoms in different settings
- Specify type ( inattentive, hyperactive, or both)
- Severity defined by degree of impairment
What are inattentive ADHD symptoms? (5)
Lack of detail focus Easily distracted Lose objects Forgetful Difficulty organizing tasks Cannot follow instructions Difficulty keeping attention Hard time listening
What are hyperactive ADHD symptoms? (5)
Leaves seat often Blurts out answers Fidgeting Running around or restless Lour or noisy Always on the go Excessive talking Cannot wait their turn Acting without thinking
What is first line med in youth with ADHD (after non pharmacological therapy)
MPH or dexamphetamine extended release
What is the condition that can develop if guanficine or clonidine are stopped quickly?
Hypertension or hypertensive encephalopathy
Name non pharmacological ADHD therapies (6)
Psychoeducation (educate parents) Shared decision making with family Parental behaviour training Classroom behaviour management Daily report card Behavioural peer interventions Organizational skills training Social skills training Cognitive training Exercise
Benefits of stimulants (3)
Improved academics Better parental reported QOL Less risky behaviour Less MVA Less anxiety and depression later on Better job
Side effects of stimulants and non stimulant ADHD meds? (3 each)
Stimulants: Appetite loss Behaviour changes Poor sleep Raynaud's Priapism Up to 2.5 cm shorter
Non stimulants:
Liver toxicity
Hypotension
Side effects of stimulants and non stimulant ADHD meds? (3 each)
Stimulants: Appetite loss Behaviour changes Poor sleep Raynaud's Priapism
Non stimulants:
Liver toxicity
Hypotension
How often should you increase a stimulant dose?
Every 1-4 weeks
What are risk factors for poor med compliance I’m ADHD?
Older age
Learning disorder
Mood disorder
Beahvioural comorbidities
What side effect do ASD patients see in stimulants for ADHD?
More stereotyped behaviour and iutbursts
3 risk factors for TB
Indigineous
Poor ventilation
Overcrowding
Foreign born in TB endemic region
BCH vaccine contraindication?
Immunodeficiency
How long after exposure to contact case does primary infection normally develop
Within 1 year
What percent of TB infections are asymptomatic?
90-95%
Who is at highest risk of early primary TB disease?
Children under 4 years old
What are two triggers for reactivation of TB?
Puberty
Immunocompromisation
Malnutrition
Steroid exposure
Name 5 disseminated regions for TB
Meningitis Disseminated (hematogenous spread and multi system) Lymphadenitis Osteomyelitis Peritonitis Liver or spleen granuloma
2 radiographic findings of early primary TB
Ground glass opacities
Hilar or mediastinal lymphadenopathy
1 disseminated disease CXR finding
Miliary nodules
ARDS pattern
Pleural effusion a
Cavitary lesions (usually upper lung field)
What is gold standard to diagnose primary or reactivated TB?
Cultures with stain, PCR, and sensitivity testing from sputum, gastric aspirate, bronchoscopy
What other infectious disease must you test for in all patients with TB?
HIV
What is TST positive size? And what are the causes of false positives or negatives?
Greater than 5 mm if immunocompromised
Greater than 10 mm in others
False positive if there is non TB mycobacterium exposure (1% of those with BCG vaccine will have false positive TST after age 10)
False negative if immunosuppressed or malnourished
In children older than 2 is IGRA or TST more specific?
In children less than 2 is IGRA or TST more sensitive?
Over 2 IGRA more specific
Under 2 TST more sensitive
Causes of false positives or negatives in IGRA
False positives: almost none
False negatives: immunocompromised
Better is children with BCG vaccine because more specific
How long must a culture positive patient with TB isolate for?
Either 2 weeks of therapy if initial sputum smear negative OR
3 negative sputum smear negative
If a child has a positive contact with index case if TB what investigations and treatment should be done?
History and physical
CXR
TST
Get index case drug sensitivity
Treat children under 5 with negative TST (under 5 mm) with single drug prophylaxis until negative TST done 8-10 weeks from last contact exposure
Treat children with TST over 5 mm as having latent infection
Don’t treat children over 5 with initial negative TST but repeat TST at 8-10 weeks from last contact exposure
What drugs do you use to treat latent TB?
Isoniazid
Rifampin
Rifapebtin or isoniazid
What is first line contraceptive for Canadian youth.
LARC
What are 2nd tier and 3rd tier contraceptive options?
2nd: hormonal contraceptives
3rd: barriers, withdrawal, spermicide
4 absolute contraindications to estrogen containing contraceptives?
Migraine with aura Severe liver disease Severe HTN Active breast CA Serious immobility after surgery History of clots
How much greater is the stroke or VTE risk on OCP?
VTE 2-4x
Stroke 1.5-2x
What is the only contraceptive option that causes weight gain?
Depo Provera
What do you need on exam before starting OCP?
BP and weight
What is a quick start contraceptive method?
If not first 7 days past LMP get bHCG
Start contraception same day
Repeat bHCG in 21 days
How long post coitus can a copper IUD be inserted for emergency contraception?
7 days
Who should get HPV vaccine?
All kids age 9-13 and any older children as catch up
How many doses of HPV vaccine are recommended and how far apart?
2 doses 6 months apart
3 doses if immunocompromised or if older than 14
What is the disorder infants can have is HPV is transmitted from mother at time of delivery?
Juvenile onset recurrent respiratory papillomatosis
Which strain of HPV causes cancer? Causes warts commonly?
CA: 16 and 18
Warts: 6 and 11
What are risk factors for HPV (3)
More lifetime sexual partners STIs Sexual abuse Young age of first sexual contact Tobacco or marijuana use Immunosuppression HIV MSM
Is HPV vaccine associated with GBS?
No
When should you discuss potential G tube insertion with a family?
When neurologic impairment is first diagnosed
Poor oral intake and weight gain
Feeding difficulties
GERD causing poor oral intake
Dysmotility despite medical treatment
Enteral feeding for >3-6 months is anticipated
What are 3 short term risks of G-tube feeding?
Peritonitis Bleeding Infection Anesthesia related problems Abdominal organ puncture Perioperative death
What are 3 long term risks of G-tube feeding?
Blockage Dislodgement Breakage Stoma infection Stoma bleeding Stoma skin irritation
3 categories of concerns to address when counselling around G-tube placement
Child topics: benefits and complications, plan for oral feeding or stimulation, socialization plan
Parent topics: meaning of feeding, logistics (finances, etc.), parent self-care, goals of care
Family topics: potential impact on siblings, anticipated reaction of extended family
Name 4 benefits to having a G-tube
Better nutrition Less hospitilization Less antibiotics Less chest infections Less feeding time Less caregiver feeding concerns Increased QOL for caregiver Ease of medication delivery
2 most common organisms causing osteoarticular infections?
S.aureus K.kingae (common in infants) S.pneumoniae S. pyogenes S. agalactiea Salmonella (in sickle cell patients) H.flu (if not vaccinated)
What is the empiric antibiotic used in osteoarticular infections? What if the child is under 4 or unimmunized?
IV cefazolin IV cefuroxime (because if covers H.flu)
What is the most sensitive and specific noninvasive test for acute osteomyelitis?
MRI with gad (still always need a baseline radiograph)
When can you switch from IV to PO therapy for acute osteomyelitis?
Clinical improvement (mild intermittent pain)
Inflammatory markers have started to normalize (CRP decreased by 50% in last 4 days or <20-30)(ESR is less reliable and decreases slowly)
Reliable oral outpatient follow up
Negative blood culture
Weight bearing or able to move affected limb
What is the most common bony location for osteomyelitis?
Metaphysis of the long bones
What is the typical age range for transient synovitis?
Age 4-10
How long after contracting Lyme disease do you expect to see Lyme arthritis develop in infected patient?
2-12 months
What skin finding is associated with CRMO? What time is CRMO pain worse?
Worse at night
Associated with psoriasis and palmoplantar pustulosis
Usually occurs in unusual places (jaw, scapula)
How long after a GI or GU infection do you expect to see reactive arthritis?
2-3 weeks later
What is a Brodie’s abscess?
Necrotic bone surrounded by new bone in region with chronic osteomyelitis for more than 4 weeks
Do you need follow up radiographs after osteomyelitis is treated? What if there is growth plate involvement
No. If growth plate is involved there is need for orthopedic follow up.
When you step down to PO antibiotics in osteomyelitis what do you use if the patient is MRSA positive?
TMP SMX, linezolid, clindamycin
What are two very important tests in S.aureus bacteremia?
MRI bone (looking for osteomyelitis) Echo (S.aureus is sticky and often becomes endocarditis even if seeded elsewhere first)
What is the duration of treatment for osteomyeltis or septic arthritis?
3-4 weeks (as long as CRP norma)
4-6 weeks if hip involved (as long as CRP normal)
Most common age to get ITP?
Age 2-5
What percetage of ITP cases self resolve by 6 months?
75-80%
What are 3 secondary causes of ITP?
Drug induced Lupus Infections Immune deficiencies Malignancy
What are 5 red flags for alternate diagnosis for ITP?
Constitutional symptoms Bone pain Recurrent thrombocytopenia Poor treatment response Lymphadenopathy Hepatomegaly Splenomegaly Signs of chronic disease Low hemoglobin High MCV Abnormal WBC Abnormal smear or morphology on smear
What classifies as mild bleeding in ITP? What are your treatment options in mild ITP?
Criteria: no bleeding, small non-ozzing petechiae on mucosa, mild resolved epistaxis, or bruising
Treatment: Observe (consider steroid or IVIG)
What are 2 recommendations to families just observing with conservative management of ITP?
No NSAIDs
No physical activity risking injury
What classifies as moderate bleeding in ITP? What are your treatment options in moderate ITP?
Criteria: troublesome epistaxis or menorrhagia, severe skin or mucosal lesions
Treatment: steroid (prednisone 4mg/kg/day divided BID for 4 days and taper or 2 mg/k/day once daily for 1-2 weeks) OR IVIG (1g/kg)
What classifies as severe bleeding in ITP? What are your treatment options in severe ITP?
Criteria: prolonged epistaxis or menorrhagia, melena, ICH, hospital admission required for bleeding
Treatment: methylprednisolone AND IVIG (1g/kg) AND platelet transfusion AND tranexamic acid (25 mg/kg/dose 3-4 times a day)
How do you manage ITP relapse or non-response?
In relapse use the same criteria as before to decide to treat.
In non-response try other (ie. steroid or IVIG) that was not yet trialed
What are disadvantages of using steroids in ITP management?
Mood change Increased weight/appetite Gastritis Hypertension Poor taste limits tolerance
What are disadvantages of using IVIG in ITP management?
Aseptic meningitis Nausea/vomiting Fever Rash Hemolysis Risks of IV placement and hospital admission
How long after giving steroids do platelets normally increase in ITP? How about after steroids?
After steroids it takes 48 h to increase.
After IVIG it takes 24 hours to respond (peak at 2-7 days)
What are the 4 Ms of healthy screen use in school aged children and adolescents?
Manage screen use
- make family media plan
- discourage media multitasking
- be present and engaged for media use
- use parental controls and privacy settings
Meaningful screen use
- prioritize routines and physical activity over screens
- focus on educational, active, or social media use
- developmentally appropriate content
Model healthy screen use
Monitor for signs of problematic screen use
- boredom without screen access
- oppositional behaviour
- interference of screens with school, play, etc.
3 benefits of appropriate screen time use in school aged children
Can improve academics, literacy, etc.
Help develop peer or teacher relationships
Video games with others encourage socialization, identity and cognitive development
Lower depression (with 1 hr day recreational screen time)
More inclusive relationships
3 risks of screen time use in school aged children
Age inappropriate or violent contact can negatively effect development/behaviour
>3 hr TV/day = increased conduct problems
High recreational screen time increases depression
Less quality material available to low income families
Less family or social interactions if high screen time
Multitasking causes worse academics
What is the recommended amount of screen time in adolescents daily?
2-4 hours a day
3 benefits of screen time in adolescents
Improved self concept
Social media is validating and allow “bounce back” from social rejection
Improved psychosocial function and emotions (if 2-4 hr/day)
Improved socialization for physically isolated children or those with less social support
3 risks of screen time in adolescents
Negative content (bullying) can cause anxiety and depression
More depression if over 6 hours/day
Lower scores in school with media multitasking
>50% of free time on games causes worse conduct, well-being, hyperactivity, and peer problems
Too much time can impact family closeness and relationships
3 negative impacts of screen time on the physical health of youth
Can decrease physical activity
TV viewing linked with decreased fruits/veggies and increased weight
Screens in bedrooms worsen sleep hygiene
Texting while driving
Headaches and vision concerns if there is too much screen use
3 positive impacts of screen time on the physical health of youth
Some promote physical activity
Health tracking with weight, diet, etc. can encourage healthy habits
Active video games are positive in short term
How old is a child before they are no longer referred to as having a global developmental delay and instead an intellectual delay?
Age 5
GDD diagnostic criteria
Significant delay (at least 2 SDS below mean) in at least 2 of the following:
- gross or fine motor
- speech/language
- cognition
- social/personal
- ADLs
ID diagnostic criteria (3)
Meet all 3 of the following:
- defects in intellectual functions (planning, problem solving, academic learning)
- defects in adaptive functions (not able to be independent or socially responsible)
- onset of both of the above during developmental period
Categories and causes of intellectual disability or GDD. (4 categories (1 example of each))
Prenatal intrinsic - genetic, metabolic, CNS malformation Prenatal extrinsic - toxin, infections Perinatal - asphyxia, prematurity, neonatal complications Postnatal - neglect, infection, trauma
What two exams should all patients with intellectual and GDD receive in their initial work up? (2)
Audiology
Ophthalmology
EEG (if suspected seizures)
What should you do for 1st investigations if a child has ID or GDD with unknown cause? (4)
Chromosomal microarray
Fragile X testing
Tier 1 investigations
Brain MRI is abnormal neuro exam or micro/macrocephaly
MECP2 in girls (moderate to severe symptoms)
What are the Tier 1 metabolic investigations for ID/GDD NYD? (7)
CBC, glucose, gas, BUN/Cr, lytes, AST/ALT, TSH, CK, ammonia, lactate, amino acids, acytlcarnitine, carnitine, homocysteine, copper, ceruloplasmin, biotinidase, ferritin (when diet restriction of PICA), vitamin B12 (when diet restriction of PICA), lead level (when risk factors), urine organic acids, urine creatine metabolites, urine purines/pyrimidines, urine GAGs
If there is no cause of IDD or GD on first tier testing what are your next steps? (2)
Neurology referral
Genetics/metabolics referral (for tier 2 work up and gene panels)
Brain MRI (if not done)
When should you do autism screnning?
Regular well child or health visits, with thorough assessment at 18 months
Earlier if: sibling with ASD, health care provider or parental or caregiver concern
What are the DSM V diagnostic criteria for autism?
Symptoms in two domains
1) Social communication impairment
2) Restricted, repetitive pattern of behaviour/interests
3) Signs and symptoms present early in development
4) Interferes with everyday life
5) Symptoms not better explained by intellectual disability or GDD
4 examples of symptoms of social communication impairment in the DSM V autism diagnosis
1) Difficulty initiating or responding to social interactions
2) Reduced spontaneous sharing of interests
3) Reduced eye contact
4) Less gestures
5) Reduced facial expressiveness
6) Use someone’s hand to get an object
7) Less interest in peers
8) Not engaging in imaginative play
4 examples of symptoms of repetitive and restrictive behaviours/interests in the DSM V autism diagnosis
1) Repeated words or phrases
2) Repetitive activity with objects
3) Repetitive body movements
4) Transient stiff posturing
5) Wearing same clothes/eating same foods
6) Distress with routine change
7) Restricted interests
8) Hypo or hypersensitive
Risk factors of ASD (3)
Male Family history Sibling with ASD Certain genetic syndromes Parents over 35 Maternal obesity, diabetes, or HTN In utero valproate, pesticide, or traffic pollution exposure Maternal rubella Pregnancy less than 12 month apart Low birth weight Extreme prematurity
Common red flags for ASD at age 6-12 months (3)
Reduced smiling Limited eye contact Limited reciprocal sound or facial expression sharing Diminished babbling or gesturing Limited response to name
Common red flags for ASD at age 9-12 months (1)
Repetitive behaviours
Unusual play
Common red flags for ASD at age 12-18 months (2)
No single words
No pointing
Lack of pretend play
Limited joint attention
Common red flags for ASD at age 15-24 months (1)
No two word phrases
Name two developmental screening tests that assess for general development and two for ASD specifically (4)
Generic: ASQ-3, Child Development Inventory, Nipissing District Developmental Screen, Brief Early Childhood Screening Assessment, Parents’ Evaluation of Developmental Status, Rourke Baby Record
ASD Specific: M-CHAT, Infant Toddler Checklist, Social Responsiveness Scale, Autism Spectrum Rating Scales, STAT, RITA-T
If the general developmental screen is concerning for ASD what should the next step be? If the next step is positive?
ASD specific rating scale
then….
Diagnostic assessment
Who can do the diagnostic assessment for ASD? While they are waiting for the assessment what referral should be immediately sent?
Pediatrician
Specialized team
Psychologist + pediatrician
They should see an early intervention service before diagnosis
Name two ways to make easier clinic visit for patients with ASD
Call family first to conduct first portion of visit virtually
Consider inviting family for a practice visit
First or last appointment of the day
Longer appointment slot
Parents bring comfort items
Rearrange room for sensory sensitivities
Common disorders to screen for or plan to manage in ASD (4)
Dental concerns (challenging and may need sedation)
Nutrition (need dietitian assessment)
GI issues (constipation, GERD, celiac) more common
Sleep disorders in 50-80%
Anxiety in 50%
ADHD in 30-50%
Depression (in older high functioning kids)
What are 2 behavioural interventions for ASD patients?
Early intensive behavioural therapy
Parent mediated interventions
Social skills training
CBT (for anxiety)