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POD qs > 2016 > Flashcards

2016 Flashcards

1
Q

What Drug is used for HIV therapy?

A

Saquinavir

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2
Q

What is an effect of Benign tumours?

A

Pressure

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3
Q

What drug is only used in the treatment of UTIs

A

Nitrofurantoin

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4
Q

What is given intravenously when treating MRSA

A

Vancomycin

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5
Q

What does the pathogenesis of systemic type 3 hypersensitivity require?

A

Immune complex formation

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6
Q

Serious infection with a Gram negative organism such as E-coli indicates treatment with what intraveneously?

A

Gentamicin

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7
Q

What is a teratoma more commonly?

A

Benign in women, malignant in men

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8
Q

serious systemic fungal infection indicates treatment with intravenous what?

A

Amphotericin B

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9
Q

What are Neutrophil polymorphs?

A

A major component of the acute inflammatory response

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10
Q

In terms of the cell cycle

A

cytokinesis is the last step in the production of daughter cells

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11
Q

what syndrome is not the result of an additional chromosome?

A

Turner syndrome

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12
Q

What do fibroblasts do?

A

produce collagen

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13
Q

What does histamine do?

A

relaxes vascular smooth muscle in acute inflammation

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14
Q

What does hypoxia do?

A
  • lack of oxygen - impedes tissue healing
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15
Q

In mitosis which phase consists of chromosomes aligning at the equator of the cell?

A

metaphase

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16
Q

Chromosomes become visible as a result of which step of mitosis?

A

Prophase

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17
Q

Why is GTN administered by the sublingual route?

A

to avoid first pass metabolism

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18
Q

Which DNA fragments analysis method does not require an electric field?

A

PCR

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19
Q

What is a mutation that causes a protein to be finished prematurely called?

A

Nonsense

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20
Q

In the process of transcription and translation what is the adapter molecule that acts between the coded amino acid and the mRNA?

A

tRNA

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21
Q

In DNA replication what is a true fact to remember?

A

The leading strand is formed continuously

22
Q

What are the types of ADR?

A 
Augmented 
Bizarre
Chronic
Delayed
End of treatment
Failure of treatment
23
Q

What enzyme is involved in phase 1 drug metabolism?

A

CYP1A2

24
Q

When is only one side of DNA replicated

A

Transcription

25
Q

What is the process that requires cooperation and coordination between mRNA tRNA and rRNA

A

Protein synthesis

26
Q

mRNA is used to form an amino acid sequence during the process of?

A

Transcription

27
Q

What does mitosis produce?

A

produces diploid cells from diploid cells

28
Q

What causes rubor and calor in acute inflammation?

A

Increased blood flow

29
Q

What drug should be used to treat an unknown gram negative bacteria?

A

gentamicin

30
Q

What does meisosis produce?

A

Produces haploid cells from diploid cells

31
Q

What does fertilisation produce?

A

produces diploid cells from haploid cells

32
Q

Where is the primary site of protein synthesis

A

Ribosomes

33
Q

The X chromosome is?

A

Transmitted by mothers to both son and daughter

transmitted by fathers to daughters but not sons

34
Q

The Y chromosome?

A

Is transmitted only by fathers

35
Q

Retinoblastoma is caused by what?

A

Is caused by a loss of tumour suppressor gene

36
Q

what is an adenocarcinoma

A

Malignant rumour of glandular epithelium

37
Q

What drug is used for both HERPES and Varicella VZV

A

aciclovir

38
Q

What drug is used topically or in oral suspension for serious fungal infection therapy?

A

Nystatin

39
Q

What drug can be used to treat Beta-lactamase producing Staph aureus

A

Flucloxacillin

40
Q

What drug is the best choice for IV treatment of serious pneumococcal, meningococcal and strep pyogenes infection as well as most other Gran positive infections?

A

Benzylpenicillin

41
Q

what does the pathogenesis of systemic type IV hypersensitivity require?

A

Gamma-interferon production

42
Q

What are Giant Cells?

A

usually a major component of granulomatous inflammation

43
Q

What does Serotonin do?

A

Produces vasoconstriction in inflammation

44
Q

How can amphotericin B be administered?

A

oral and IV

45
Q

How can Beta lactamase resistance be combatted?

A

can be combatted with co-amoxiclav

46
Q

What is ciprofloxaci?

A

it is a fluoroquinolone that inhibits nucleic acid synthesis

47
Q

What drug inhibits purine synthesis

A

Trimethoprim

48
Q

Name the major eukaryotic histone

A

H1, H2A, H2B, H3, H4

49
Q

How may chromosomes do you expect to label in each karyotype when using FISH to probe for X Chromosomes in Turner syndrome patient?

A

1

50
Q

Which is the most suitable method of testing whether a healthy individual is a carrier forsickle cell anaemia?

A

Karyotyping

POD qs (1 decks)

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