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[OS 215] OB Patho E2 > 2014 > Flashcards

2014 Flashcards

1
Q

Which of the following tissues will be likely to be negative for estrogen receptors?

A. normal breast duct

B. lactating duct

C. hyperplastic duct

D. poorly differentiated ductal carcinoma

A

D

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2
Q

Which of the following has the worst prognosis?

A. Ductal carcinoma, no specific type

B. Mucinous carcinoma

C. Tubular carcinoma

D. Lobular carcinoma

A

A

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3
Q

The following carcinomas involve tubular duct lobular units except for:

A. Lobular carcinoma

B. Invasive ductal carcinoma

C. Angiosarcoma

D. Metaplastic carcinoma

A

C

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4
Q

Tissue fat necrosis of breast tissue can be clinically misdiagnosed as neoplasia

A. True

B. False

A

NA

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5
Q

Seen in autoimmune mastitis:

A. FORGOT

B. Dense collagenous stroma

C. Perivascular inflammation

D. Predominance of lymphatic infiltrates

A

NA

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6
Q

The characteristic dyshesive loose pattern sometimes seen in lobular carcinoma is due to the lack of:

A. Estrogen

B. Human epidermal growth factor

C. E-cadherin

D. P63

A

C

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7
Q

The intergrity of the myoepithelial cells defines whether a breast carcinoma is in situ or invasive

A. True

B. False

A

A

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8
Q

Microinvasive carcinoma is diagnosed only when the invasive foci measures 1mm or less and the rest of the lesion will show only in situ lesion. There should be no other invasive foci measuring more than 1 mm.

A. True

B. False

A

A

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9
Q

A metaplastic carcinoma will have all of the following features except

A. a malignant epithelial component

B. a metaplastic epithelial component

C. a metaplastic stromal component

D. a benign, dense stromal component

A

B

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10
Q

Characteristic of classic medullary carcinoma except:

A. Presence of recognizable ducts

B. Pleiomorphic cells

C. Lymphoplasmocytic changes

D. Estrogen receptor negative

A

C

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11
Q

The most important prognostic factor in breast carcinoma is

A. status of axillary lymph nodes

B. histologic type of tumor

C. multifocality

D. family history

A

A

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12
Q

True of sporadic breast cancers except

A. Younger age of menarche

B. Estrogen dependent

C. Affects older age group

D. One has increased risk if paternal grandmother has breast CA

A

D

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13
Q

Hereditary breast cancer is commonly associated with the following except

A. younger age group

B. more aggressive than sporadic breast cancer

C. negative for estrogen and progesterone receptors

D. most common is medullary carcinoma

A

C

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14
Q

Which of the following has the best prognosis?

A. mucinous carcinoma

B. invasive papillary carcinoma

C. well-differentiated invasive ductal carcinoma

D. microinvasive ductal carcinoma

A

D

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15
Q

Difference between phyllodes and fibroadenoma

a) Size of tumor. Phyllodes larger than FA
b) Border. FA has well defined border
c) Stromal cell. Phyllodes have more cellular stroma
d) Ductal patterns. FA has pericanalicular growth pattern

A

C

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16
Q

Not a fibroepithelial lesion

A. Fibroadenoma

B. Phylloides tumor

C. Spindle cell CA

A

C

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17
Q

Metastatic foci from a malignant phylloid tumor arise from which part of the primary lesion?

A. Stroma

B. Ducts

C. Both Ducts and Stroma

D. None of the above

A

A

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18
Q

Bloom and Richardson grading includes the following except:

a. Mitotic count
b. Degree of duct formation
c. Nuclear grade
d. Size of tumor

A

D

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19
Q

Which of the following is NOT a morphologic pattern of ductal carcinoma in situ?

a. Solid
b. Cribriform
c. Papillary
d. Metaplastic

A

D

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20
Q

This type of DCIS present with cookie cutter shapes and thick bridges

a. Solid
b. Mucinous
c. Cribriform
d. Papillary

A

C

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21
Q

Lobular carcinoma can metastasize to the following organs EXCEPT:

a. Leptomeninges
b. Female genital tract
c. Gastrointestinal tract
d. Thyroid gland

A

D

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22
Q

Seen in fat necrosis except:

a. foamy macrophages
b. giant cell
c. lympholytic infiltrates
d. dense fibrotic stroma

A

C

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23
Q

Poorly differentiated ductal carcinomas arise en toto from well differentiated breast carcinomas

A. True

B. False

A

B

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24
Q

Fibroadenoma can have hyalinized stroma and atrophic ducts in postmenopausal women.

A. True

B. False

A

A

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25
Q

A ductal carcinoma in situ will have myoepithelial cells in:

A. the fibrovascular core only

B. both the fibrovascular cores and periphery of the lesion

C. the periphery of the duct

D. the endothelial lining of the blood vessels

A

C

26
Q

Not true of lobular neoplasia:

A. arise from lobular duct terminal units

B. positive for e-cadherin

A

B

27
Q

This inflammatory lesion is characterized by keratin plugs in the nipple

A. duct ectasia

B. lymphocytic mastopathy

C. squamous metaplasia of the lactiferous duct

D. Paget’s disease

A

C

28
Q

Which of the following morphology is not associated with in situ ductal lesions?

A. cribriform

B. medullary

C. papillary

D. micropapillary

A

B

29
Q

What are the 2 most important prognostic factors for invasive ductal carcinoma?

A. lymph node status and tumor size

B. tumor size and mitotic count

C. sentinel lymph node status and tumor metastasis

D. tumor size and distant metastasis

A

A

30
Q

Invasive Papillary Carcinoma in the absence of myoepithelial cells.

A. Fibrous _________ and p_______

B.

C. Periphery of the cells

D. Endothelial lining of the blood vessels

A

NA

31
Q

This lesion presents with crusted excoriations and shows large cells with eosinophilic cytoplasm at the basal layer

A. invasive ductal carcinoma

B. Paget’s disease

C. ductal carcinoma in situ

D. micropapillary

A

C

32
Q

What infection/lesion affects the testes first?

A. Chlamydia

B. TB

C. Syphilis

D. E. Coli

A

C

33
Q

Testicular mass with a lesion consisting of a reticular network of cuboidal and elongated cells. Structures consist of central capillary surrounded by parietal and visceral layers. Scattered hyaline-like globule are also present.

A. spermatocytic seminoma

B. embryonic carcinoma

C. endodermal sinus tumor

D. gonadoblastoma

A

C

34
Q

Testicular mass with a lesion consisting of a reticular network of cuboidal and elongated cells. Structures consist of central capillary surrounded by parietal and visceral layers. Scattered hyaline-like globule are also present.

The tumor in this question secretes this

a. AFP
b. HCG
c. estrogen
d. testosterone

A

A

35
Q

Term for inflammation of the glans and the prepuce of the penis?

A. balanitis

B. balanophosphitis

C. phimosis

D. paraphimosis

A

B

36
Q

Does not develop into an invasive squamous cell carcinoma

A. Erythroplasia de Queyrat

B. Bowen’s Disease

C. Bowenoid Papulosis

A

C

37
Q

Abnormal opening of the urethra on the ventral surface of the penis is:

A. Hypospadias

B. Epispadias

C. Phimosis

D. Priapism

A

A

38
Q

Occurs when a tight foreskin is forcibly retracted, and edema of the glans prevents its replacement

A. phimosis

B. paraphimosis

C. epispadias

D. hypospadias

A

B

39
Q

Fibrotic plaque with involvement of fascia causing curvature of penis

A. Priapism

B. Peyronie’s plaque

C. urethritis

D. phimosis

A

B

40
Q

This presents with papillary, keratinizing lesions in the glans.

A. HSV

B. Condyloma latum

C. Condyloma acuminata

A

C

41
Q

True for squamous cell carcinoma of the penis except:

A. Neonates have the same risk for it as adults.

B. HPV-related

C. can spread to inguinal lymph nodes

D. first affects the glans and prepuce

A

A

42
Q

The primary hormone responsible for libido, sex drive, and erection:

A. prolactin

B. estrogen

C. testosterone

D. hCG

A

C

43
Q

Congenital anomaly characterized by an incomplete descent of testis into the scrotal sac

a. Cryptochordism
b. Varicocoele
c. Hydrocoele
d. Testicular torsion

A

A

44
Q

Histological change in cryptorchid testes except

a. developmental arrest of germ cells
b. thickening and keratinisation of basement membrane
c. Leydig cells are spared
d. continuous production of spermatozoa in a fibrosed state

A

D

45
Q

Changes in the testis seen in this condition includes congestion and even extravasations of blood into the interstitial tissues

A. Torsion of the spermatic cord

B. Orchitis

C. Varicocoele

D. Cryptorchidism

A

A

46
Q

Varicosities of the pampiniform plexus, common in young men and gives a “bag of worms” feel on physical examination.

A. torsion of spermatic cord

B. orchitis

C. varicocoele

D. cryptorchidism

A

C

47
Q

Which of the following is not a germ cell tumor?

a. Leydig cell tumor
b. yolk sac tumor
c. teratoma
d. choriocarcinoma

A

A

48
Q

True of the yolk sac tumor of the testis except:

A. increased AFP levels

B. Schiller Duvall bodies are seen

C. Also called endodermal sinus tumor

D. increased CA-125 levels

A

D

49
Q

Cells in tumor divided into lobules by fibrous or delicate septate with lymphocytes. Cells are round or polyhedral with central nuclei with one or more prominent nucleoli.

A. Choriocarcinoma

B. Teratoma

C. Seminoma

D. Yolk Sac Tumor

A

C

50
Q

The cytoplasm of tumor cells of seminoma contain:

a. glycogen
b. glucose
c. sterols
d. mucopolysaccharides

A

A

51
Q

The cells grow in alveolar, tubular, papillary and are large and hyperchromatic.

A. Seminoma

B. Yolk Sac Tumor

C. Choriocarcinoma

D. Embyronal Carcinoma

A

D

52
Q

The germ cell tumor which will show cytotrophoblast and syncytiotrophoblast and elevated hCG levels:

a. embryonal carcinoma
b. teratoma
c. choriocarcinoma
d. leydig cell tumor

A

C

53
Q

A transilluminating lesion of the tunica

a. hydrocoele
b. chlocoele
c. hematocoele

A

A

54
Q

21 year old with a well-defined moveable doughy breast lesion

a. fibrocystic change
b. ductal carcinoma
c. fibroadenoma
d. phyllodes tumor

A

C

55
Q

Picture of a breast lesion with central necrosis

A. Comedocarcinoma

B. Cribriform

C. Papillary

D. Microinvasive

A

A

56
Q

21 y/o female with fairly defined breast lesion with cysts on cut sections

a. fibrocystic change
b. fibroadenoma
c. phyllodes tumor
d. micropapillary carcinoma

A

A

57
Q

Picture of Invasive Lobular Carcinoma

Will it stain + for Estrogen receptor, + for Progesterone receptor, and + for E-cadherin receptor?

a. Yes
b. No

A

B

58
Q

Identify the probable lesion.

a. apocrine metaplasia
b. fibroadenoma
c. phylloides tumor
d. metastatic carcinoma of the breast

A

A

59
Q

This penile lesion is associated with what pathogen?

A. Human Papilloma Virus
B. Herpes Simplex Virus
C. Treponema pallidum
D. Neisseria gonorrhea

A

A

60
Q

What do these multinucleated cells secrete?

A. HCG
B. CEA
C. AFP
D. LDH

A

A

61
Q

This pathognomonic structure is what type of testicular tumor:

A. Sertoli cell tumor
B. Leydig cell tumor
C. Endodermal sinus tumor
D. Embryonic carcinoma

A

C

[OS 215] OB Patho E2 (2 decks)

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