20 Cards Flashcards
Mifepristone
Mifepristone is used in combination with misoprostol to terminate pregnancies. Misoprostol is a prostaglandin analog that causes uterine contractions.
Mechanism of action
competitive progesterone receptor antagonist
Adverse effects
menorrhagia
Breakthrough analgesia administration
Breakthrough analgesia should be administered at 1/6th of the total daily opioid dose. In this case the patient takes 60 mg of long acting morphine sulphate in a 24 period. Therefore an appropriate breakthrough analgesia = 60 mg / 6 = 10 mg of short acting morphine (oramorph).
What should be given in CKD if glucose control is needed
DPP4 inhibitor -liptin
What should be monitored after prescribing amiodarone
Thyroid function
What OD/toxicity is atropine used to reverse
Organophosphate poisoning
What OD/toxicity is urinary alkalinization used to reverse
Aspirin, phenobarbital, methotrexate
What OD/toxicity is fomepizole used to reverse
Ethylene glycol - antifreeze
Methanol - windshield washer fluid, paint thinners
Isopropanol - rubbing alcohol, hand sanitisers
What OD/toxicity is flumazenil used to reverse
Benzodiazepine
What OD/toxicity is IV bicarbonate used to reverse
Aspirin
Phenobarbital
Methotrexate
What OD/toxicity is desferrioxamine used to reverse
acute iron poisoning
Precipitants of digoxin toxicity
Hypokalemia
Increasing age
Renal failure
MI
hypomagnesemia, hypercalcemia, hypernatremia, acidosis
hypoalbuminemia
hypothermia
hypothyrodisim
meds: amiodarone, verapamil, diltiazem, spironolactone, ciclosporin, thiazides, loop dieuritcs
Side effects of CCBs
HA, flushing, ankle edema
SFX of beta blockers
Bronchospasm, fatigue, cold peripheries, sleep disturbances
SFX of nitrates
HA, postural hypotension, tachycardia
SFX of nicorandil
HA, flushing, anal ulceration
What is the most important prognostic factor in paracetamol OD
Acidosis
Other prognostic indicators in paracetamol OD
Creatinint >300, increased prothrombin time
What agent is used to reverse adrenaline induced ischemia
Phentolamine
Drugs that may cause urinary retention
TCAS, opiods, anticholinergics, NSAIDS
SFX of PDE 5 inhibitors
Visual disturbances: blue discolouration, non arteric ischemic neuropathy
Nasal congestion
Flushing
GI sfx
HA
Priapism
Clin F of aspirin OD
Tinnitus, dizzy, increased RR, sweating, hyperthermia
