2 Oral Mucosa Overview Flashcards
turnover of epithelium is impacted by what?
keratinization, stratification, and functional demands
what are the 3 types of oral epithelium
- SSNK
- SSPK
- SSK (stratified squamous orthokeretatinized meaning within oral cavity)
what primary cell type gives rise to SSK, SSPK, and SSNK?
keratinocyte
what produces keratin (cytokeratin) proteins?
keratinocyte
what provides structural support and minimizes mechanical stress?
keratin (cytokeratin) proteins
production of ___ results in eosinophilia of cytoplasm
keratin
what contains proteins that aggregate cytokeratin (intermediate filament) produced by stratum granulosum?
keratohyalin granules
what is a single layer of stem cells that self renews and gives rise to amplifying daughter cells (stratum spinosum)
stratum basale
how is stratum basal bound to basement membrane?
hemidesmosomes
stratum basal is found in which types of epithelium?
SSK, SSNK, and SSPK
how do keratinocytes mature?
upward migration and increase in size
turnover time of keratinocyte
dependent on cell proliferation and migration thru layers, ending in desquamation (shedding)
describe this interaction:
during development, the underlying lamina propria (CT) determines the type of epithelium
epithelial-mesenchyme interaction
epithelium can respond to environmental stimuli and alter phenotype resulting in:
adaptive response
what is the time to move from stratum basal to surface?
turnover rate
what are the turnover rate influencing factors?
- proliferation rate
- degree of keratinization
- stratification
- environment/external factors
is non-keratinized or keratinized slower?
keratinized is slower
what are environmental/external factors that affect turnover rate
- chemotherapeutics
- acute inflammation (increase turnover)
- severe inflammation (decrease turnover)
- frictional forces
outcomes of turnover
- desquamation (shedding, exfoliation)
- atrophy (loss of epithelium)
- hyperplasia (increased cell number)
does desquamation prevent bacterial colonization?
YES
type of epithelium and turnover (days) of:
thick skin
SSK
40-55 days
type of epithelium and turnover (days) of:
thin skin
SSK
30-40 days
type of epithelium and turnover (days) of:
hard palate
SSPK
24 days
type of epithelium and turnover (days) of:
buccal
SSNK
14 days