2: Metabolic Syndrome Flashcards
Name the components of metabolic syndrome.
- Abdominal obesity
- Insulin resistance +/- glucose intolerance
- HTN
- Atherogenic dyslipidemia / Hyperlipidemia
- Proinflammatory state
- Prothrombic state
When should screening for risk factors for CV dx begin?
2 yo
Starting at age 2, what is done at office visits for CV risk?
- Graph BMI by percentile
- Identify overweight/obese
- Lipids (if risk factors)
When do you start screening glucose?
- Screen if overweight, family history, or hypertensive
- Otherwise at age 10
How is obesity (metabolic syndrome) defined in children <10 yo?
- WC >90th percentile
- BMI >85th percentile
T/F Below the age of 10, metabolic syndrome is not a diagnosis.
True. However, NIH now has reference ranges for triglycerides for metabolic syndrome at this age.
How is metabolic syndrome defined in the 10-16 yo age range?
- WC >90th percentile or adult cut off
- Triglycerides >150
- HDL <40
- BP >130 or >85
- FPG >100 or known DMT2
When would you perform an oral GTT?
If FPG >100-125 and DMT2 not known (age range 10-16)
How is metabolic syndrome defined in the 16+ age range?
- WC >94 cm for males
- WC >80 cm for females
- Triglycerides >150 or treated
- HDL <40 males, <50 females, or treated
- BP >130 or >85 or treated
- FPG: >100 or known DMT2
T/F In children, it is better to look at all non-HDL lipids together than just LDL and triglycerides alone.
True
What are total cholesterol ranges for children?
- Normal <170
- Borderline 170-199
- High 200+
What are LDL ranges for children?
- Normal <110
- Borderline 110-129
- High 130+
Name 7 clinical outcomes of metabolic syndrome.
- CV dx
- DMT2
- PCOS
- Fatty liver
- Cholesterol gall stones
- Asthma
- Sleep disturbances / Sleep apnea
When should lipid screening be done universally?
- Between ages 9-11
- Again at 17+
Who should receive liver function testing?
- High cholesterol
- Obesity
