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Opath II, Block 6 > 2. Immune mediated disease > Flashcards

2. Immune mediated disease Flashcards

1
Q
A
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1
Q

Opath II, block 6

Smoking decreases risk

A

Recurrent apthous stomatitis

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2
Q

Opath II, block 6

Decrease in CD4/CD8 ratio and increased TNFa, increase in inflammatory mediators (IL2 and 6)

A

RAS

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3
Q

Opath II, block 6

Reddish area with slight elecation, often produces tingling sensation , diam., edges are regular , non-jagged, surrounded by a reddish halo

A

Recurrent apthous stomatitis

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4
Q

Opath II, block 6

Thialidomide

A

Tx of type C RAS: teratogenic, don’t give to pregnant women

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5
Q

Opath II, block 6

Intralesional triamcinolone (kenalog)

A

RAS - type B (1/mo) for deep ulcers/injections

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6
Q

Opath II, block 6

DISCONTINUITY OF SF EPITHELIUM. Nonspecific ulcerated* sf covered by fibrouspurulent exudates infiltrated by PMNs. Zone of granulation tissue with dilated capillaries and filled with PMNs macrophages, plasma cells beneath. Deeper layers: repair process

A

Minor apthous ulcers [RAS: histology]

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7
Q

Opath II, block 6

**HLA-b51 (mexican, middle eastern, and asians), anticardiolipin antibodies, C-Reactive protein (CRP) elevated, chronic anemia/PMN leukocytolysis (15%)

A

Behcet syndrome

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8
Q

Opath II, block 6

Pathergy test (~to a TB test)

A

Behcet Syndrome

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9
Q

Opath II, block 6

Crops of mouth ulcers, genital ulcers, eye inflammation

A

Behcet Syndrome

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10
Q

Opath II, block 6

Dx: recurrent mouth ulcers with any two of the following (Triad of Systems) : eye inflammation, genital ulcerations, skin abnormalities, and erythema nodosum (skin lesions spontaneously appearing as raised, tender, reddish nodules)

A

Bechet syndrome

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11
Q

Opath II, block 6

STDs/Chlamydia

A

Reactive Arthritis (Reiter’s Syndrome)

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12
Q

Opath II, block 6

Hemorrhagic crusting of vermillion borders of the lips

A

Erythema multiforme

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13
Q

Opath II, block 6

Bulls eye skin lesions

A

EM Minor

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14
Q

Opath II, block 6

Steven’s Johnson syndrome

A

EM Major (acute form: found in young pts)

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15
Q

Opath II, block 6

Always triggered by Rx rxn, mortality 30-35%, epidermal detachment >30% and results in electolye loss and wide spread infection

A

TEN (toxic epidermal necrolysis) - most severe form of EM

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16
Q

Opath II, block 6

Dekeratinization and desquamation of filiform papillae

A

Geographic Tongue

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17
Q

Opath II, block 6

Clinical correlation with fissured tongue

A

Geographic tongue (or Melkersson-Rosenthal syndrome if oral/facial granulomatosis and facial paralysis are also sx)

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18
Q

Opath II, block 6

Association with psoriasis, seborrheic dermatitis, and atropy

A

Geographic tongue

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19
Q

Opath II, block 6

Ageusia, Dysgeusia, lichenoid reaction, epithelial sloughing

A

Allergic Contact Stomatitis

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20
Q

Opath II, block 6

Patch test for dental materials, oral flavorings, preservatives, balsam of peru, and cinnamon

A

Allergic contact stomatitis

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21
Q

Opath II, block 6

Amalgam sensitivity will cause what kind of rxn

A

Lechenoid rxn

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22
Q

Opath II, block 6

Labial enlargement and facial swelling

A

Melkersson-Rosenthal Syndrome

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23
Q

Opath II, block 6

Normal epithelium covering connective tissue showing perivascular infiltrate consisting of lymphocytes and plasma cells with multiple discrete epitehlioid granulomas

A

Orofacial granulomatosis

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24
Q

Opath II, block 6

A manifestation of crohns disease, sarcoidosis, and melkersson-rosenthal syndrome

A

Orofacial granulomatosis

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25
Q

Opath II, block 6

Serology: sedementation rate, CRP, and ANCA (anti-neutrophil cytoplasmic ab)

A

Orofacial granulomatosis

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26
Q

Opath II, block 6

Hypersensitivity due to an inhaled antigen which results in necrotizing franulomatous lesions of the respiratory tract, glomuronephritis

A

Wegener’s granulomatosis

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27
Q

Opath II, block 6

Strawberry gingivitis

A

Wegener’s Granulomatosis

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28
Q

Opath II, block 6

Subepithelial split at BM, IgG and C3

A

MMP

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29
Q

Opath II, block 6

Abs against collagen VII

A

Epidemolysis Bullosa Acquisita

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30
Q

Opath II, block 6

IgA Abs

A

Linear IgA

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31
Q

Opath II, block 6

DSG3, suprabasalar spinous layer

A

Pemphigus Vulgaris

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32
Q

Opath II, block 6

Tzanck cells

A

Pemphigus Vulgaris

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33
Q

Opath II, block 6

Fishnet appearance on IF

A

Pemphigus Vulgaris

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34
Q

Opath II, block 6

Patient already diagnosed with cancer

A

Paraneoplastic Pemphigus

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35
Q

Opath II, block 6

DSG1, subcorneal split (in spinous layer)

A

Pemphigus Follaceus

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36
Q

Opath II, block 6

IVIG, Ritumaxib

A

Refractory pemphigus

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37
Q

Opath II, block 6

Wickham’s Striae

A

Reticular LP

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38
Q

Opath II, block 6

Hyperkeratotic , leukoplakic, raised or flat on tongue and buccal mucosa

A

Plaque Form LP

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39
Q

Opath II, block 6

Looks like MMP, but has white striae and is precancerous

A

Erosive LP

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40
Q

Opath II, block 6

Large bullae rupture and cause erosion

A

Bullous LP

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41
Q

Opath II, block 6

Erosions and white striae around amalgam

A

Lichenoid reaction

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42
Q

Opath II, block 6

LP invades the nerve

A

SCC

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43
Q

Opath II, block 6

Band of T lymphocytes around BM, thickening of BM, degeneration of basal cells, antifibrinogen Ab

A

Lichen Planus

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44
Q

Opath II, block 6

Topical tx that is not a steroid (good for DM and HTN pts)

A

Tacrolimus

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45
Q

Opath II, block 6

Malar rash, photosensitivity

A

Lupus Erythematosis

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46
Q

Opath II, block 6

ANA+, dsDNA+, anti-smith Abs

A

Lupus Erythematosis

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47
Q

Opath II, block 6

Brown tumor

A

Hyperparathyroidism

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48
Q

Opath II, block 6

Vitamin D deficiency in children

A

Rickets

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49
Q

Opath II, block 6

Vitamin D deficiency in adults

A

Osteomalacia

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50
Q

Opath II, block 6

Increased osteoid, decreased mature bone

A

Rickets/osteomalacia

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51
Q

Opath II, block 6

Deficiency of bone tissue per unit volume of bone, treat with bisphosphonates

A

Osteoporosis

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52
Q

Opath II, block 6

Three diseases with low serum Calcium levels

A

Primary hyperparathyroidism, rickets and osteomalacia

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53
Q

Opath II, block 6

Disease with elevated serum Calcium levels

A

Secondary hyperparathyroidism

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54
Q

Opath II, block 6

Bleeding gingiva, gingivitis, periodontitis, loosening teeth and eosinophilic granuloma

A

Hangerhan’s cell histocytosis

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55
Q

Opath II, block 6

Giantism and acromegaly

A

Hyperpituitarism

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56
Q

Opath II, block 6

Change in size and of tissues /space btn teeth (less change in bony architecture): enlargement of hypophyseal fossa, thickening of the outer table of the skull, and enlarged paranasal sinuses

A

Hyperpituitarism

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57
Q

Opath II, block 6

Mandibular pronathism, increased growth of bone and tissues

A

acromegaly

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58
Q

Opath II, block 6

hair on end–radial striations in the diploic space of the skull

A

Sickle cell anemia/thalassemia

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59
Q

Opath II, block 6

Rg: changes in bone marrow – LARGE marrow spaces with thin delicate trabeculae, thin cortical plates, enlarged maxilla but small sinuses

A

Sickle cell anemia/thalassemia

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60
Q

Opath II, block 6

Osteomyolitis, hypercementosis, and potential to get osteosarcoma

A

Paget’s Disease

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61
Q

Opath II, block 6

Bilateral uncontrolled growth of bone w/ cement lines “reversal lines

A

Paget’s Disease

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62
Q

Opath II, block 6

Similar presentation as fibrous dysplasia except patients are older and have Bilateral lesions

A

Paget’s Disease

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63
Q

Opath II, block 6

Osteoporosis circumscripta, grandular /ground glass/cotton wool, then RO

A

Paget’s Disease

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64
Q

Opath II, block 6

Tab tests: increased hydroxyproline in urine (increased collagen destruction), elvated ALP (due to osteoclastic activity), hypercalciuria, and normal serum ca2+

A

Paget’ s Disease

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65
Q

Opath II, block 6

Sclerodactyly, widening of PDL space, Reynaud’s syndrome

A

Scleroderma

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66
Q

Opath II, block 6

Enlarged Langerhan’s cells, eosinophils and “floating teeth”

A

Langerhan’s cell histiocytosis

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67
Q

Opath II, block 6

Acute Disseminated LCH

A

Letter-siwe disease

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68
Q

Opath II, block 6

Bone lesions, diabetes insipidus and exophthalmos

A

Hand-Schuller-Christiansen Triad= Multifocal LCH

69
Q

Opath II, block 6

PTCH mutation

A

Gorlin syndrome

70
Q

Opath II, block 6

Multiple OKCs and basal cell carcinomas

A

Gorlin syndrome

71
Q

Opath II, block 6

RET mutation

A

MEN2B

72
Q

Opath II, block 6

Marfanoid body build, oral mucosal neuromas, medullary carincoma of the thyroid, pheochromocytoma

A

MEN2B

73
Q

Opath II, block 6

APC mutation

A

Gardner Syndrome

74
Q

Opath II, block 6

Multiple osteomas, impacted teeth, odontomas, 100% develop colorectal carcinoma

A

Gardner Syndrome

75
Q

Opath II, block 6

STK11 mutation

A

Peutz-Jeghers Syndrom

76
Q

Opath II, block 6

Benign polyps, freckle-like spots on perioral skin and hands)

A

Peutz-Jeghers syndrome

77
Q

Opath II, block 6

NF1 mutation

A

Neurofibromatosis Type 1

78
Q

Opath II, block 6

Café au lait spots, crowe’s sign, lisch nodules

A

Neurofibromatosis type 1

79
Q

Opath II, block 6

Port wine stains along CN V, leptomeningeal angiomas

A

Sturge-Weber Angiomatosis

80
Q

Opath II, block 6

Hypermobility of joints, elastic skin, gorlin sign

A

Echler-Danlos Syndrome

81
Q

Opath II, block 6

Red papules, family hx, epistaxis, AV-malformation

A

Hereditary hemorrhagic Telangiectasias

82
Q

Opath II, block 6

Peg-shaped incisors, heat intolerance (can’t sweat)

A

Ectodermal Dysplasia

83
Q

Opath II, block 6

RUNX2 mutation

A

Cleidocranial Dysplasia

84
Q

Opath II, block 6

Hypoplastic clavicle, delayed eruption of permanent teeth

A

Cleidocranial Dysplasia

85
Q

Opath II, block 6

Café au lait spots, sexual precocity, fibrous dysplasia

A

McCune-Albright Syndrome

86
Q

Opath II, block 6

Fe deficiency + glossitis + dysphagia

A

Plummer-Vinson Syndrome

87
Q

Opath II, block 6

Facial paralysis, swollen lips, fissured tongue

A

Melkerson-Rosenthal Syndrome

88
Q

Opath II, block 6

Esophageal webs

A

Plummer-Vinson Syndrome

89
Q

Opath II, block 6

Erosion, osteophytes, subchondral sclerosis

A

Osteoarthritis

90
Q

Opath II, block 6

Inherited skin condition with no other allergic conditions

A

Atopic dermatitis

91
Q

Opath II, block 6

Scratching leads to excoriations

A

Eczema

92
Q

Opath II, block 6

Itchy skin rash.begins hours after contact

A

Allergic contact dermatitis

93
Q

Opath II, block 6

Excessive contact with irritatnts, causes hand dermatitis

A

Irritant Contact Dermatitis

94
Q

Opath II, block 6

Increased skin cell turnover with slow shedding

A

Psoriasis

95
Q

Opath II, block 6

Auspitz’s sign

A

Psoriasis

96
Q

Opath II, block 6

Histamine causes angioedema of lips and hands

A

Urticaria

97
Q

Opath II, block 6

Abnormal C1NH protein

A

Angioedema (w/out urticaria)

98
Q

Opath II, block 6

Tongue blade test

A

Physical urticaria= dermatographism

99
Q

Opath II, block 6

5 physical uticaria

A

Dermographism, cold uticaria, exercise induced anaphylaxsis, cholenergic uticaria, and contact uticaria

100
Q

Opath II, block 6

P. Acnes

A

Acne

101
Q

Opath II, block 6

Affects areas exposed to sunlight over a long period of time, solar elastosis also involved

A

Solar comedones

102
Q

Opath II, block 6

Migraine headaches, sun damage, erythema, telangiectasia

A

Rosacea

103
Q

Opath II, block 6

Mixed population of staph and strep

A

Impetigo

104
Q

Opath II, block 6

Collection of pus in a firm mass caused by S. aureous

A

Furuncles

105
Q

Opath II, block 6

Survive in dead keratin

A

Dermatophyte infections

106
Q

Opath II, block 6

Survive in dead keratin

A

Dermatophyte infections

107
Q

Opath II, block 6

Athlete’s foot

A

Tinea pedis

108
Q

Opath II, block 6

Jock itch

A

Tinea cruris

109
Q

Opath II, block 6

Ringworm

A

Tinea corpuris

110
Q

Opath II, block 6

Ringworm of the scalp

A

Tinea capitus

111
Q

Opath II, block 6

Burrow into skin

A

Scabies

112
Q

Opath II, block 6

Do NOT burrow, transmitted by combs

A

Pediculosis (lice)

113
Q

Opath II, block 6

Larvae enter swimmer’s pores and die

A

Swimmer’s Itch

114
Q

Opath II, block 6

Increased epithelial turnover rate

A

Dandruff

115
Q

Opath II, block 6

Hair loss from crash diets

A

Telogen effluvium

116
Q

Opath II, block 6

Abrupt hair loss from chemo

A

Anagen effluvium

117
Q

Opath II, block 6

Patchy hair loss from autoimmune condition

A

Alopecia areata

118
Q

Opath II, block 6

Jellyfish and coral stinging structures

A

Nematocyts

119
Q

Opath II, block 6

Antimicrobial anti-HIV components of saliva

A

HIV-specific IgA, SLIPI

120
Q

Opath II, block 6

Dark pink submucosal swelling

A

Lymphoid hyperplasia

121
Q

Opath II, block 6

Normal low PMN counts

A

Benign ethnic neutropenia

122
Q

Opath II, block 6

Absence of PMNs, caused by anticancer chemotherapeutic agents

A

Agranulocytosis

123
Q

Opath II, block 6

Periodic reduction in PMN population

A

Cyclic neutropenia

124
Q

Opath II, block 6

Decreased production, increased destruction, sequestration in spleen

A

Thrombocytopenia

125
Q

Opath II, block 6

Increase in mass of RBCs.TIA, CVA, MI

A

Polycythemia Vera

126
Q

Opath II, block 6

Scooped out mandible, floating teeth, large langerhan’s cells

A

Langerhan’s cell histiocytosis

127
Q

Opath II, block 6

Blast transformation, 9/22 translocation

A

CML

128
Q

Opath II, block 6

Reed-sternberg cells

A

Hodgkin’s Lymphoma

129
Q

Opath II, block 6

Owl-eye nucleus

A

Hodgkin’s lymphoma

130
Q

Opath II, block 6

B-lymphocytes affected, MALT formation

A

Non-Hodgkin’s Lymphoma

131
Q

Opath II, block 6

Cells have minimal cytoplasm

A

Non-Hodgkin’s Lymphoma

132
Q

Opath II, block 6

starry sky appearanc

A

Burkitt’s Lyphoma

133
Q

Opath II, block 6

Kids, posterior jaws, multiple quadrants affected

A

Burkitt’s Lymphoma

134
Q

Opath II, block 6

B-lymphocyte malignancy associated with EBV

A

Endemic Burkitt’s Lymphoma

135
Q

Opath II, block 6

Bence-Jones protein, amyloid deposition

A

Multiple myeloma

136
Q

Opath II, block 6

Eccentric nuclei, stippled nuclear chromatin

A

Multiple myeloma

137
Q

Opath II, block 6

Plasma cell origin, Punched out lesions on radiograph

A

Multiple myeloma

138
Q

Opath II, block 6

Glossitis, angular cheilitis, koilonychias, splenomegaly

A

Anemias

139
Q

Opath II, block 6

VIII-A and IX-B deficiency

A

Hemophilia

140
Q

Opath II, block 6

Impaired collagen synthesis results in bleeding gums

A

Vitamin C deficiency/Scurvy

141
Q

Opath II, block 6

White, creamy, removable plaques

A

Pseudomembranous oral candidiasis (thrush)

142
Q

Opath II, block 6

Elongated hyphae, thigmotropism

A

Oral candidiasis

143
Q

Opath II, block 6

Diagnosed using periodic acid Schiff

A

Oral candidiasis

144
Q

Opath II, block 6

Treated with Amphotericin B

A

Deep Mycoses

145
Q

Opath II, block 6

Leads to CNS involvement

A

Crytococcosis

146
Q

Opath II, block 6

Cough, anemia, shiny papules, 3rd most common

A

Penicilliosis

147
Q

Opath II, block 6

Reactivation of latent infection, fever, weight loss

A

Histoplasmosis

148
Q

Opath II, block 6

Reactivation of latent infection, fever, weight loss

A

Histoplasmosis

149
Q

Opath II, block 6

Causes sinus infection and invasive lesions

A

Aspergillosis

150
Q

Opath II, block 6

Viscera, lymph nodes, mucocutanous tissues affected

A

Blastomycosis

151
Q

Opath II, block 6

Pulmonary infection and erythema multiforme

A

Coccidiomycosis

152
Q

Opath II, block 6

Erythematous linear banding, not related to plaque

A

Linear gingival erythema

153
Q

Opath II, block 6

Destruction of one or more interdental papillae

A

NUG

154
Q

Opath II, block 6

Loss of periodontal attachment and bone

A

NUP

155
Q

Opath II, block 6

Ulcers on non-keratinized mucosa

A

Aphthous ulcers

156
Q

Opath II, block 6

Ulcers on keratinized mucosa

A

HSV

157
Q

Opath II, block 6

In HIV, will cross onto the “wet” lip

A

HSV

158
Q

Opath II, block 6

Stops at midline along one dermatome

A

Herpes zoster

159
Q

Opath II, block 6

NO langerhan’s cells, chromatin margination, EBV

A

Oral hairy leukoplakia

160
Q

Opath II, block 6

HPV-related lesions

A

Verruca vulgaris, condyloma acuminatum, focal epithelial hyperplasia

161
Q

Opath II, block 6

HHV-8, cancer of lymphatic endothelium and forms blood-filled vascular channels

A

Kaposi’s Sarcoma

162
Q

Opath II, block 6

HIV increases risk by 60x

A

Non-hodgekin’s lymphoma

163
Q

Opath II, block 6

HIV-related salivary gland disease

A

Sjogren-like syndrome, diffuse CD8 lymphocytic infiltration (DILS), lymphoepithelial cysts of salivary glands, malignant lymphoma

164
Q

Opath II, block 6

Improving immune system reduces Tregs and worsens clinical symptoms

A

IRIS

165
Q

Opath II, block 6

Organophosphate reversal agent

A

Pralidoxime

166
Q

Opath II, block 6

Rx to block muscarine effects

A

Atropine

167
Q

Opath II, block 6

Donepexil

A

Alzheimers

168
Q

Opath II, block 6

Echothiophate, pilocarpine, carbachole-

A

Glaucoma

169
Q

Opath II, block 6

Atropine poisoning and central anticholinergic symptoms

A

PHYSOstigmine

170
Q

Opath II, block 6

Reversal of neuromuscular block (paralysis)

A

Edrophonium or neostigmine

171
Q

Opath II, block 6

Myasthenia gravis

A

PYRIDOstigmine

Opath II, Block 6 (1 decks)

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