2 - A&P Flashcards

1
Q

Kidneys and ureters location

A

Retroperitoneal structures located between T11 and L 3

R = 2cm lower than L

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2
Q

Layers of the kidney?

A

Renal fascia
Adipose capsule
Renal capsule

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3
Q

Kidney internal structures?

A
Renal cortex
Renal colums
Renal medulla
Renal pyramids
Renal papillae
Calyces
Renal pelvis
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4
Q

What is the functional tissue of the kidneys?

A

Renal parenchyma

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5
Q

Kidney pic

A

Slide 8

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6
Q

Renal blood flow

A

Abdominal artery - segmental arteries - interlobar a. -> arcuate a. -> interlobular a. -> afferent arterioles (toward nephrons) -> glomerulus

Efferent arterioles (away from nephrons) -> peritubular capillaries -> interlobular v. -> arcuate v. -> interlobar v -> segmental veins -> renal veins -> IVC

Slide 11 pic

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7
Q

Afferent vs efferent

A

Afferent approaches

Efferent exits

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8
Q

Where do kidney nerves arise?

A

Superior mesenteric ganglion -> hilum

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9
Q

What do sympathetic fibers do?

A

Regulate blood flow
-This filtrates blood and forms urine

RAAS system

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10
Q

Nephron consists of?

A

Renal corpuscle (glomerulus + bowman’s capsule)

Renal tubules

Slide 14/15 pic

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11
Q

Renal tubules consist of

A

PCT
Loop of henly
DCT
- becomes the juxtaglomerular apparatus

DCT drains into collecting duct

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12
Q

Kidneys role in urinary system

A

Functional organs of the urinary system

The other parts are just passage ways and storage

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13
Q

Main functions of kidney?

A
  1. Regulate blood ionic composition
    - electrolytes (Na, K, Ca, Cl, po4) (or whatever phosphate is, jeeze john)
  2. Regulate pH
    - excretion of H ions into urine
    - conserving bicarb
  3. Regulation of blood volume
    - ADH or vasopressin
  4. BP regulation
    - juxtaglomerular cells - renin activates the RAA pathway
  5. Maintenance of blood osmolarity
    - regulating water excretion/loss
  6. Production of hormones
    - calcitriol, erythropoietin
  7. Regulation of blood glucose levels
    - renal gluconeogeneis
  8. Excretion of waste and foreign substances
    - ecogenous substances (drugs)
    - Endogenous substances
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14
Q

Where is renin produced?

A

Juxtaglomerular (JG) cells

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15
Q

Where is angiotensinogen produced?

A

Liver

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16
Q

Where is angiotensin I produced

A

Renin acts on angiotensinogen converting it into angiotensin I

17
Q

Angiotensin II

A

Converted in blood from angiotensin i by ACE

18
Q

Where does aldosterone come from?

A

Adrenal cortex

19
Q

RAA pic

A

Slide 24

20
Q

Renal gluconeogenesis

A

Renal release of glucose into the blood to help maintain blood glucose level

21
Q

Exogenous vs endogenous substances?

A

Exogenous - toxins and drugs

Endogenous

  • amonia and urea (amino acids)
  • bilirubin and hemoglobin catabolism
  • creatinine (breakdown of creatine phoshate in muscle)
  • uric acid from nucleic acid catabolism
22
Q

Explain glomerular filtration?

A

Basically blood flows into glomerulus, plasma comes out, solids stay in

23
Q

Components of filtration membrane?

A

Glomerular endothelial fenestrations (pores) - allow proteins out but not cells/platelets

Basal lamina - small and med proteins out

Slit membrane - only very small proteins

Pic 32

24
Q

Glomular filtration fraction?

A

Ratio of fluid from blood that becomes glomular filtrate

-20% of total fluid that reaches kidneys enters the capsular space

1-1.2L/min
140-180 L/day

25
Q

Pressures that determine GFR

A

GBHP - Glomerular blood hydrostatic pressure
- 55mmHg - promotes filtration of wastes

CHP - capsular hydrostatic pressure
-15mmHg - opposes filtration

BCOP - blood colloid osmotic pressure
- 30mmHg - opposes filtration

Pic slide 35q

26
Q

Normal net filtration pressure?

A

10mmHg

27
Q

Urine production steps?

A
  1. Glomular filtration
  2. Tubular reabsorption
  3. Tubular secretion
28
Q

Tubular reabsorption?

A

Tubule cells reabsorb 90% of fltrate

Water and useful solutes (glucose, electrolytes, proteins etc) get kept

29
Q

Tubular secretion?

A

Tubule and duct cells secrete waste, drugs and excess ions into fluid

1-1.5L of urine/day

30
Q

Urine composition?

A

95% water

5% electrolytes, solues, exogenous substances

31
Q

Factors affecting urine volume/production

A

fluid intake – blood pressure – blood osmolality (measure of osmoles of solute per kg of
solvent) – diet – body temperature – diuretics/medications – mental state – general health

32
Q

Location of bladder?

A

Posterior to pubic symphysis,
anterior to rectum in males,
anterior to vagina in females

Held in place by periotoneal folds

33
Q

Bladder wall?

A
3 layers
Mucosa 
- rugae, 
- transitional epithelium 
- lamina propria 

Muscularis (detrusor mucle)

  • inter longitudinal
  • middle cirucular
  • outer longitudinal
Serosa 
- covers superior surface
- visceral peritoneum 
Or adventitia
- covers posterior and inferior surfaces
- continuous w ureters
34
Q

I just went on a very strict renal friendly diet.

A

There are only three things you can’t put in your mouth- a fork, knife and spoon.