2 Flashcards
What are the 4 types of medicines that are identified as high risk, and so useful for MURs
NSAIDs –> Adherance to gastric protection?
Anticoagulants (including LMWHs) –> APTT
Antiplatelets –> Possible GI Bleed (No aspirin!)
Diuretics –> Non-adherence is bad
Name some things that determine whether we monitor certain patients?
The drug they’re on –> Warfarin needed more than in paracetamol
Disease state –> Drugs like paracetamol are more important when being used in somebody with liver dysfunction, than in those with a healthy liver
Acute Disease –> More intensive than chronic diseases
Certain Patient Factors –> Eg, when pregnant, immunocompromised and the elderly
Whats the DOTS classification? In terms of adverse drug reactions
Dose Relatedness –> They can occur at 3 different levels…
Supra-therapeutic = Toxic levels
Therapeutic levels = Collateral (unintentional) effects
Sub-therapeutic = Hyper-susceptibility reactions
Time –> Can occur at anytime, but often due to changes in patient factors (such as renal function)
Susceptibility –> Varies due to patient factors (eg, age/gender/pregnancy/co-morbidities/drug interactions)
What is duty of candour?
A legal duty that tells us that we have to own up to our mistakes and be held responsible for them
What are the 4 guiding principles of Medicines Optimisation?
Aim to understand the patients experience
Evidence based choice of medicine
Ensure medicines use is as safe as possible
Make medicines optimisation a part of routine practice
What’s the difference between an adverse drug reaction, and an adverse drug event?
Drug Reaction –> A reaction that is reasonably attributable to the drug
Drug Event –> An event that occurs whilst a patient is taking a drug (but the drug isn’t necessarily the cause of the event)
What type of monitoring parameter does recording INR fall under?
Haemotological
How many of the 400 MURs a year must be done on targeted groups?
70%
What are the 4 Patient Orientated Outcomes (POOs)?
Reduction in side effect and medication errors
Better access to a large range of services
More effective use of medicines
Greater involvement in my own care with support when needed
What is Medicines Optimisation?
An approach to the quality use of medicines that aims to produce the best possible outcomes for patients and maximise the value from medicines
What are the 4 largest groups of drugs that cause ADRs?
Diuretics
NSAIDs
Warfarin
Antiplatelets
How long does it normally take an IV drug to reach the steady state?
4 half lives
What are the 4 Clinical Laboratory Services?
Clinical Biochemistry
Haematology/Immunology
Histopathology
Microbiology/Virology
What are the 2 types of contraindications?
Relative –> Caution should be used, but the drugs can be used if the benefits outweigh the benefits
Absolute –> The interaction could cause a life-threatening situation. This should always be avoided
What treatments should be given for somebody undergoing an anaphalactic shock?And why?
Adrenaline –> Reduces swelling, wheezing and increases BP
Steroids –> Reduction of inflammation and swelling
Antihistamines –> Reduces swelling and inflammation
IV Fluids –> Replaces fluids that are lost through leaky capillaries
Which group of drugs has caused the most ADRs?
NSAIDs
What are the 4 target areas for an NMS?
Hypertension
Anti-platelet/Anticoagulant
Type 2 diabetes
Asthma/COPD
<p>What is clinical governance?</p>
Audits Risk management Education and Training Openness R&D Clinical effectiveness
What are the conditions for a respiratory MUR?
Must be on 2 medications, with at least one being for asthma or COPD and on the list for an NMS
Medicines optimisation will offer a step change in how issues are addressed through….
Patient Engagement
A Focus on Outcomes
Pharmaceutical Leadership
A holistic view across the medicines pathway
When should a Post Discharge MUR be done?
4 weeks after discharge ideally…..but can be 8 weeks in certain circumstances
What are the main risk factors of the drug to patients, in reference to allergies?
Nature of the Drug –> Aspirin/Penicillins/anticonvulsants/antipsychotics
Degree of Exposure –> Occurs more for intermediate courses than of moderate doses
Route of Administration –> Oral safer than IV, but topical is more sensitising
Cross-Reactivity
What are the conditions for a cardiovascular MUR?
Patients with, or at risk of, CVD and on at least 4 medications
One of these medications must be for CVD, Diabetes or thyroid
What characteristics of a drug means we need to monitor drug levels in the serum?
When there is a large degree of inter-patient variability
Narrow therapeutic-index
Odd/unpredictable PKs
State the ABCDE classifications of adverse drug reactions
A = Augmented B = Bizarre C = Chronic --> Continuous exposure D = Delayed --> occurs a long time after exposure E = End of use
In medicines optimisation, what does QIPP stand for?
Quality
Innervation
Productivity
Prevention
To be competent, or have capacity to consent, a patient must be able to do what 4 things?
Understand the information that has been given
Believe the information
Be able to retain and weigh up the information to make a decision
Be free from any kind of duress (against their will) to make the decision
Who can report ADRs to the MHRA? (yellow card scheme)
Anyone!
What’s the difference between Allergy and Intolerance?
Allergy –> When an immune system react to substances in the environment that are harmless to most people
A type B (Bizarre) hypersensitivityIntolerance –> When somebody has a lower threshold to the normal pharmacological action of a drug
A type A (Augmented) hypersensitivity
Which is the most frequent type of prescribing error?
Dosage errors
What was found to have the greatest impact on dispensing errors?
Workload
What is Part XVIIIA?
The black listThese items cannot be prescribed/dispensed on the NHS
What are the 3 different categories for drugs in Part VIIIA?
Cat A –> Drugs that are readily avaliable
BB is allowed for smallest pack size of over £50
Cat C –> Priced on basis of drugs that are not readily available as generics
BB is allowed
Cat M –> Readily available drugs which the department of health determines the reimbursement price
BB is allowed
What are the 4 criteria that a pharmacy must adhere to, to qualify for the quality payment scheme?
Offering MUR/NMS
NHS Choices entry for pharmacy must be up-to-date
Pharmacy staff must be able to send/receive NHS emails
EPS2 must be being used ongoing
A script for 105ml of amoxicillin oral suspension comes into your pharmacy. If you only have bottles of 100ml avaliable….what quantity do you supply?
200mlThis is because you have to fully supply the script, and the NHS BSA will pay you for the full 200ml, not just the 105ml on the Rx
When would a script be endorsed as NCSO?
When a drug (in part VIII) cannot be obtained for a reason, and so a more expensive version needs to be bought instead….like a branded version (above the price stated in the drug tariff)NCSO = No cheaper stock avaliable
Which part of the Drug Tariff states the ‘Basic Prices of Drugs’?
Part VIIIA
What is the Selected List Scheme (SLS)?
When certain drugs can be given on an FP10, when normally blacklisted, under specific circumstancesEg, Clobazam for epilepsy
What is Part IX?
AppliancesAll are out unless stated…. so specific dimensions are needed for things like dressings
What are the 2 lists included in Part XV Borderline substances?
List A –> Products and conditions for what each product can be used for (alphabetical index of products)
List B –> Conditions and what products can be used (alphabetical index of conditions)The script should have been endorsed with ACBS by the prescriber
Give a couple of examples of drugs that dont have their discount (from the manufacturer) deducted via the NHS
Immunoglobulins Insulins for injections Vaccines Cold Chain storage items Sch 1/2/3/ CDs
When would a script be endorsed with BB?
BB = Broken BulkThis would be done when the quantity on the Rx is less than the minimum amount that can be ordered from the supplier. This is usually for an unusual product that you won’t supply again.So you still get paid for the stock that is left over, that otherwise wouldnt be used. You cannot claim this for another 6 months on the same product (as it is assumed you’ve used the left over quantitiy to supply any more scripts)
When would a script be endorsed with XP or OOP?
XP/OOP = Out of pocket
This would be done in exceptional circumstances when there has been a high cost to get a product in that is not often dispensed (eg, delivery charges for specials)The cost must exceed 50p
What do you need to keep CDs in a non-regulation storage container (eg, a safe or gun locker)?
An exemption certificate
How many months worth of CDs are you allowed to take abroad without a licence?
3 months
What are the 3 drugs that can be prescribed for addiction that require the Dr to have a specific licence?
Diamorphine, Cocaine and Dipipanone (and salts)
What class of CD do you need to obtain an extra licence (from the home office) for to supply/possess?
Class 1
What class of CDs do you need to add to the CD register?
Class 1 and 2Also Savitex (Sch4 part 1) due to cannaboid nature
What is the maximum duration of a drug that can be prescribed on FP10MDA?
14 days
What is the name of the script/form that is legally needed for requisitions of Sch 2/3 drugs in the community?
FP10CDF
Which schedule drugs have limited restriction on import/export?
Sch 4(II) dont need a licence for patients to import/exportSch5 have zero restrictions
Who is the only person that is allowed to grant a licence for somebody to possess, supply, manufacture, import or export control drugs?
The secretary of state
What common requirment for a prescription is not needed for a CD requisition?
No date required!
When are the 2 exceptions that a pharmacist can possess a class 1 drug without a licence from the home office?
For destructionFor handing over to the police
Why would you add a fixed weight to studies in a meta analysis?
So thay bigger studies have a greater influence
What is an non-inferiority design?
When a RCT is done to see if a drug is ‘not inferior’ to the standard treatment