2. 11/09 F + E Flashcards
- antr pit gland
produces follicle stimulating hormone and leutinising hormone which influences the 3 phases of the ovarian cycle and the menstrual cycle.
primary hormones secreted by hypothalamus
- corticotrophins releasing hormone (CRH)
- gonadotrophin releasing hormone GnRh
- growth hormone releasing hormone GHRH/GH inhibiting hormone GHIH aka somatostatin
- prolactin releasing hormone / prolactin inhibiting hormone PIH aka dopamine
- thyrotropin releasing hormone TRH
- anti diuretic hormone ADH and oxytocin
reproduction cycle phases + locations
pituitary; brain
ovarian; ovaries
menstrual; uterus
pituitary cycle
- Hypothalamus receives positive feedback and releases GnRH to anterior pituitary, either releases FSH or LH depending on stage of menstrual cycle.
- FSH —> Graafian follicle.
- Oestrogen produced, negative feedback to antr pit. Antr pit stops producing FSH and starts LH, GF ruptures and ovulation occurs. /
- Egg released and looking for sperm, LH increases.
- LH —> CL formed, producing estrogen and progesterone, preparing for implantation, however if no implantation the CL degenerates, causing menstruation.
Graafian follicle development
primordial follicle, early primary follicle, late primary follicle, secondary primary follicle, Graafian follicle (FP) , rupturing follicle (O) corpus luteum (LS), corpus albicans.
ovarian cycle
- follicular/proliferative phase
- ovulation
- luteal/secretory phase
follicular/proliferative phase
- follicles enlarge and one matures, or ripens, each month (Graafian Follicle).
- graafian follicle swells and becomes tense.
- oestrogen dominant.
ovulation
- releases ovum into fimbulated end of uterine tube.
luteal/secretory phase
- cells of the ruptured follicle proliferate to make structure irregular in shape and yellow in colour ‘Corpus Luteum’
ovarian hormones which influence reproduction cycle
oestrogen, progesterone, relaxin
oestrogen effect on repro cycle
- inhibits FSH release so only one egg matures in a cycle.
- stimulates the pituitary gland to release the hormone LH.
progesterone effect on repro cycle
- acts on the endometrium to prepare for implantation.
- raises body temperature by 0.5°C after ovulation and causes tingling and sense of fullness of breasts prior to menstruation.
relaxin influence on repro cycle
- small amounts cause uterine quiescence which is the ideal environment for fertilised oocyte to implant.
repro cycle summary; follicular
FSH stimulates growth of several follicles, dominant follicle secretes oestrogen, oestrogen inhibits growth of other follicles (and FSH), oestrogen stimulates development endometrium
repro cycle summary; ovulation
surge in LH causes ovulation, rupturing of follicle creates corpus luteum