1st Quiz Flashcards
Affects drug activity by either changing the effective concentration of the drug at its site of action or by changing the rate at which the drug is eliminated, hence, affecting the length of time of which effective concentrations are maintained
Protein-binding factor
Movement of a drug to the body tissues
Distribution
Dosage that reaches the systematic circulation that is readily available to act on the body cells
Bioavailability
What happens to a drug from the time it enters the body until it enters the circulating fluid
Absorption
Duration of time it takes for a drug’s effect to come to prominence
Onset of drug action
Refers to the amount of drug metabolite concentrations in the body in the time course of the drug
Intensity of drug action
Specific areas on cell membranes that react with certain chemicals to cause an effect within the cell
Receptor sites
Drugs that directly interact with receptor sites to cause the same activity that natural chemicals would cause at that site
Agonist
Binds to the same receptor site preventing the agonist from binding
Competitive antagonist
Binds at different receptor sites but still prevents agonist from binding
Noncompetitive antagonist
The actual concentration that a drug reaches in the body results with:
Dynamic equilibrium
The amount of a drug that is needed to cause a therapeutic effect
Critical concentration
A higher dose than that usually used for treatment to reach the critical concentration
Loading dose
The way the body deals with a drug, including absorption, distribution, biotransformation, and excretion
Pharmacokinetics
The ability of a drug to attack only those systems found in foreign cells
Selective toxicity
