1st Aid/Emma Holliday's review Flashcards
A patient who is crying on minute and laughing the next is said to have a ___ affect.
Labile
What is the difference between MOOD and AFFECT?
Mood is what the pt tells you
Affect is how thier mood appears
What is psychosis?
What are the common types?
A general term used to describe a distorted perception of reality.
Common types:
- delusions (false beliefs)
- hallucinations (perceptions without acutal extermal stimuli)
- disorganized thinking/behavior
What are the common causes of psychosis?
- Secondary to another medical condition
- Substance induced
- Delerium
- Dementia
- Bipolar (manic and/or mixed episodes)
- MDD with psycotic features
- Brief psychotic disorder
- Schizophrenia
- Schizophreniform
- Schizoaffective
- Delusional disorder
What are the common causes of psychosis secondary to another medical condition?
- CNS diseases (CVD, MS, neoplasm, Alzheimer, Parkinson, Huntington, AIDS, epilepsy, prion, enchephalitis, syphilis)
- Endocrinopathies (Addison/Cushing, hyper/hypothyroid)
- Vitamin deficiency (B12, folate, niacin)
- SLE, temporal arterits
What are the labs to order when doing an initial work up of psychosis?
TSH, RPR, drug screen,
What are the POSITIVE symptoms of schizophrenia?
Things that are ADDED to baseline. Hallucinations, delusions, bizarre behavior, disorganized speech.
These tend to respond to anti-psychotics
What are the NEGATIVE symptoms of schizophrenia?
Things that are SUBTRACTED from baseline. flat/blunted affect, anhedonia, apathy, alogia
These tend to be resistent to anti-psychotics (responds a little better to atypicals than typicals)
What are the 3 phases fo schizophrenia?
- Prodromal: decline in global function that precedes the FIRST episode
- Psychotic: “The episode” Delusions, halucinations, and disordered thought
- Residual: follows a psychotic episode. mild delusions/halucinations, negative symptoms.
Which antipsychotic can lead to agranulocytosis?
Clozapine
What is the downward drift of schizophrenia?
People with schizophrenia tend to be unable to function in society and thus find themselves in a lower SES, often homeless.
schizophrenia often involves neologisms. What is a neologism?
A new word/expression that only has meaning to the schizophrenic
What are the 1st Gen antipsychotics?
Are they typical or atypical?
1st Gen = typical
The 1st Gen antipsychotics are:
Haloperidol
Fluphenazine
Trifluoperazine
Pimozide
Holy Fuck That’s Psycho!
What are the 2nd Gen antipsychotics?
Are they typical or atypical?
2nd Gen = atypical
The 2nd Gen antipsychotics are:
Risperidone Quentiapin Olanzapine Aripiprazole Ziprasidone
What is a common side effect of 2nd Gen antipsychotics?
metabolic sybndrome
What is a common side effect of HIGH potency antipsychotics?
extra-pyramidal:
- dystonia of face, neck, and tongue
- Parkinsonism (resting tremor, bradykinesia)
- akathisia (uncontrollable restlessness)
What is a common side effect of LOW potency antipsychotics?
Anticholinergic:
- dry mouth
- constipatoin
- hyperthermia
What is Neuroleptic Malignant Syndrome?
A rare potential side effect of 1st Gent anti-psycotics that NBME likes to test.
S/Sx:
- AMS
- Autonomic instablility (fever, labile BP, tachycarida, tachypnea, diaphoretic)
- “lead pipe” rigidity
- high CPK
- leukocytosis
- metabolic acidosis
Tx: dantrolene
What is Schizophreniform d/o?
Schizophrenia lasting between 1 and 6 months
What is Schizoaffective d/o?
Meet criteria of BOTH schizophrenia and a major depresive/manic episode with the delusions/hallucinations predominating and also existing during a >2week period of absence of the mood episode
What is a brief psychotic d/o?
Schizophrenia lasting less than 1 month
What is Delusional d/o?
Pt has 1+ delusions lating >1month, but does not meet the criteria for schizophrenia and it does not significantly impact function.
Can be:
- Erotomanic (false belief that someone is in love with them)
- Grandiose (false belief that they have a great talent)
- Somatic (false belief that they have some physical difference)
- Persecutory (false belief that they are being persecuted)
- Jealous (false belief that thier significant other is unfaithful)
- Mixed/unspecified (multiple/none of the above)
What is Koro?
a delusion specific to southeast asian cultures that one’s penis will recede into your body and you will die.
note: none of my residents or attendings can ever recall seeing this on a test but….I had to include this…I just had to…
What is the difference between a mood episode and a mood disorder?
An episode are the distinc periods of time (or, you know, episode) in which the patient is experiencing said mood
A disorder is a pathologic pattern of reccurent mood episodes.
What are the criteria for a Major Depressive Episode?
Depressed mood/anhedonia plus 4 of the SIGECAPS for >2weeks
What are the criteria for Major Depressive Disorder?
at least ONE major depressive episode and ZERO episodes of mania
What are the criteria for a Manic Episode?
A period of persistantly elevated mood and energy plus 3 of the DIGFAST for >1week and impairs social/occupational function
What does SIGECAPS stand for?
S= sleep changes: increase during day or decreased sleep at night I= interest (loss): of interest in activities that used to interest them G= guilt (worthless): depressed elderly tend to devalue themselves
E= energy (lack): common presenting symptom (fatigue)
C= cognition/concentration: reduced cognition &/or difficulty concentrating A= appetite (wt. loss); usually declined, occasionally increased P= psychomotor: agitation (anxiety) or retardations (lethargic) S= suicide/death preocupation
What does DIG FAST stand for?
D = Distractibility and easy frustration I = Irresponsibility and erratic uninhibited behavior G = Grandiosity
F = Flight of ideas A = Activity increased with weight loss and increased libido S = Sleep is decreased T = Talkativeness
What is a hypomanic episode?
Elevated mood/energy lasting >FOUR days but does not impair function, require hospitalization, or come with psycotic features.
What are the criteria for Bipolar I Disorder?
at least ONE manic episodes. thats it. no depressive episodes needed.
What are the criteria for Bipolar II Disorder?
at least ONE depressive episodes and at least ONE hypomanic episodes.
If there is a single manic episode it is BP I.
What is the first line treatment of MDD?
SSRI and therapy.
What is the neurobiology of the positive symptoms of schizophrenia?
Too MUCH DA in the limbic system.
1st Gen Antipsychotics work by blocking D2 receptors
What is the neurobiology of the negative symptoms of schizophrenia?
Too LITTLE DA in the prefrontal/meso-cortical tract
this is why 1st Gen Antipsychotics tend to make negative sx worse
How do you treat Schizophreniform d/o? Brief psychotic d/o? Does treatment prevent progression to schizophrenia?
You treat both Schizophreniform d/o and Brief psychotic d/o with typical antipsychotics.
Treatment DOES NOT prevent progression to schizophrenia
You have a 22yo female with a 3 year history of MDD who comes to you saying she has been hearing voices saying that she needs to kill herself despite adhering to her medication regimen. What is the treatment of choice?
Electroconvulsive therapy (ECT).
It can be used for mania and refractory MDD with psychotic features in non-pregnant pts as well. This just points out that it is safe in pregnancy.
a 35yo schizophrenic is brought to the ED by his brother and begins to get disruptive and threatening to the nursing staff. What is the drug of choice? Why?
Haloperidol.
It is fast acting and comes in an IM form (not going to trust him to take PO meds or let you start an IV)
What are the 2 low-potency antipsychotics that the NBME tests the most?
Chlorpromazine
Thioridazine
What are the 2 high-potency antipsychotics that the NBME tests the most?
Fluphenazine
Haloperidol
Which antipsychotic do you give to non-compliant patients? why?
Risperdal decanoate, Fluphenazine decanoate and Haloperidol decanoate.
decanoate means that it’s an IM that last 2-4 weeks
What is the biggest risk factor for suicide?
Prior suicide attempt.
What is seen on polysonography in pts with MDD?
decreased REM latency (they get into REM faster) and increased cycles of REM.
*remember REM is not “restful” 3rd/4th phase (“deep”) sleep is. More REM=less deep sleep.
What medical conditions can mimic MDD?
lots!
These 4 kept coming up in all of the resources:
HIV, Hypothyroid, Lyme, and a left MCA stroke
A patient complains of decreased mood, increased eating, gaining weight, sleeping more and has leaden paralysis in the morning. What is the diagnosis? Treatment of choice?
Atypical Depression. Apparently leaden paralysis is NBME buzzword for atypical depression.
Best treated w/ MAOIs.
A 75 yo man is brought in by his daughter because he has been sleeping very little for the past 8 days, had sex with 15 different women at the home, and talked so quickly that he has been stumbling over his words. What must be on your differential as to the cause of this manic episode?
Right frontal hemisphere stroke
Which drug classes can trigger a manic episode in a misdiagnosed Bipolar patient?
SSRIs and TCAs
A bipolar patient begins taking advil daily for low back pain and develops n/v/d, coarse tremor, ataxia, confusion, and slurred speech.
What is the diagnosis?
What are the pathologic ECG findings?
What is the treatment?
Lithium toxicity. It can be precipitated by NSAIDs.
ON ECG you will classically find T-wave flattening/inversion and U waves
The treatment is fluid resuscitation. you have to flush it out. Emergent dialysis if lithium level is >4 or they begin to show signs of acute kidney disease
What is the therapeutic level of lithium?
0.6-1.2
Why is lithium contraindicated in pregnant women? What is the preferred treatment?
If taken in the 1st trimester it can cause ebstien anomoly in the fetus (malformed tricuspid valve)
The preferred treatment is Clonazepam.