1b Psychiatry Through the Lifetime Flashcards

1
Q

Why do changes in the brain occur at different times?

A

Both the gray and white matter have different maturations times, and so changes in the brain happen at different times.

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2
Q

Where is the maximum density of grey matter reached first?

A

primary sensorimotor cortex

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3
Q

Where is the maximum density of grey matter reached last?

A

higher association areas such as the dorsolateral prefrontal cortex.

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4
Q

What causes the neural imbalances in adolescence?

A

Adolescence is a period of neural imbalance caused by early maturation of subcortical brain areas and delayed maturation of prefrontal control areas

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5
Q

In highly emotional situations what is the biggest driver of behaviour?

A

in highly emotional situations, the more mature limbic and reward systems will affect behaviour more strongly than the still relatively immature prefrontal control system.

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6
Q

10 year old girl, doesn’t want to sleep in the room alone, gets raised heart rate, sweating and difficulty breathing in crowded places and does not like doing presentations in class

A

Anxiety

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7
Q

10 year old boy, several attendances to GP and Emergency Department with recurrent abdominal pain, no physical cause found so far

A

Somatinization

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8
Q

15 year old young woman with tiredness, sleeping 12 hours/day, irritability and reduced enjoyment from her hobbies

A

Depression

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9
Q

4 year old boy, language is behind peers in class, doesn’t interact much with others, prefers watching buses/trains to playing in the playground

A

Autism

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10
Q

8 year old boy who has been fidgeting in lessons, speaking out of turn and struggling to stay focused on homework tasks

A

ADHD

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11
Q

9 year old boy, has been using increasing amounts of alcohol hand gel, wearing rubber gloves when going outdoors and lining up the toys in his room before going to sleep

A

OCD

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12
Q

10 year old boy with involuntary movements in the face, neck and arms as well as making sounds which are not context-appropriate

A

Tic syndrome

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13
Q

15 year old young man with conduct disorder has been truanting from school and stealing mother’s credit cards; he was found smelling of cannabis, and more recently has been smoking it in his bedroom

A

Substance Misuse

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14
Q

16 year old young woman who has been cutting herself with a razor when feeling distressed, and recently has bought several packets of paracetamol

A

Self Harm

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15
Q

14 year old girl who has been spending a lot of time thinking about her weight, has cut out carbohydrates from her diet, has been skipping breakfast and is using grandfather’s laxatives to lose weight

A

Eating Disorders

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16
Q

What are the genetic risk factors for ADHD?

A

No isolated gene for ADHD, there are likely multiple genes conferring vulnerability for developing it
Twin studies have shown a significant heritability for ADHD - as high as 76%
First degree relatives of children with ADHD have an ADHD diagnostic probability 4-5x higher than the general population
Boys are more vulnerable than girls (2:1 – 3:1)

17
Q

What are the environmental risk factors of ADHD

A

Premature birth
Low birth weight
Prenatal smoking exposure

18
Q

What are the core features of ADHD?

A

Persistent pattern of inattention / hyper-activity/impulsivity
Present for at least 6 Months
Present in two or more settings

19
Q

What is dementia?

A

Degenerative disease of the brain with:
cognitive and behavioural impairment
sufficiently severe to interfere significantly with social and occupational function

20
Q

What is the most common cause of dementia?

A

Alzhemiers

21
Q

What are the features of mild dementia?

A

May live independently but some supervision/support often needed

Can still take part in community activities and can appear unimpaired to those who do not know them

Judgement and problem solving typically impaired
Social judgement may be preserved

Difficulty making complex plans/decisions and handling finances

22
Q

What are the features of moderate dementia?

A

Require supports to function outside the home and only simple household tasks are maintained
Difficulties with basic activities of daily living (ADL’s), such as dressing and personal hygiene
Significant memory loss
Judgment and problem solving are typically significantly impaired, and social judgment is often compromised

23
Q

What are the features of severe dementia?

A

Severe memory impairment
Often total disorientation for time and place.
Often completely unable to make judgments or solve problems.
May have difficulty understanding what is happening around them.
Fully dependent on others for basic personal care in activities such as for bathing, toileting and feeding.
Urinary and faecal incontinence may emerge at this stage.

24
Q

What behavioural and psychological disturbances might be seen in dementia patients?

A

Includes apathy, mood disturbances, hallucinations, delusions, irritability, agitation, aggression and sleep changes

25
Q

Attention deficit hyperactivity disorder (ADHD) is characterised a by a triad of….

A

inattention, impulsivity and hyperactivity

26
Q

What is the Hakin-Adams Triad which is present in dementia?

A
  1. Cognitive Impairment / Confusion
  2. Urinary Frequency / incontinence
  3. Gait Disturbance
27
Q

What are amyloid plaques which are found in dementia patients?

A

Amyloid plaques - insoluble β-amyloid peptide deposits as senile plaques or β-pleated sheets in the hippocampus, amygdala, and cerebral cortex. Increased
density with advanced disease.

28
Q

What are Neurofibrillary tangles?

A

Neurofibrillary tangles (NFTs) - consist of phosphorylated tau protein and are found in the cortex, hippocampus, and
substantia nigra. (NFTs also found in
normal ageing.