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ENDOCRINOLOGY > 1b Disorders of Vasopressin > Flashcards

1b Disorders of Vasopressin Flashcards

1
Q

What is the physiological action of vasopressin?

A

Stimulation of water reabsorption into the renal collecting duct = concentrates the urine

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2
Q

what are the 2 posterior pituitary hypothalamic nuclei called and for which hormone? What are the neurons called?

A

magnocellular nuerons from supraOptic and paraVentricular nuclei

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3
Q

What are the two enantiomers named as and which is biodegrable?

A

L & D and L is

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4
Q

Which receptor does AVP work through?

A

V2 receptor in the kidney

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5
Q

How does AVP work as a vasoconstrictor?

A

Via the V1 receptor

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6
Q

Describe how AVP concentrates the urine?

A
  • AVP binds to V2 receptor on basolateral membrane
  • This triggers intracellular cascade (g protein etc) resulting in the movement of aquaporin-2 molecules onto the apical membrane
  • this allows the movement of water from the urine into the blood, therefore concentrating it
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7
Q

What is the physiological action of vasopressin aka ADH? (3)

A
  • Stimulation of water reabsorption- acts through V2 receptor in the kidney
  • Also a vasoconstrictor via V1 receptor
  • Stimulates ACTH release from anterior pituitary
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8
Q

What is the bright spot on an MRI of the pituitary?

A

Posterior Pituitary

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9
Q

What are the two stimuli for vasopressin release?

A

Osmotic and Non-osmotic

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10
Q

Describe how the osmotic stimuli for vasopressin release works?

A

rise in plasma osmolality (conc) detected by osmoreceptors. Water moves out via osmosis and change in shape causes nuerone firing - AVP release

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11
Q

Describe how the non-osmotic stimuli for vasopressin works?

A

decrease in atrial pressure sensed by atrial stretch receptors STOP INHIBITION of AVP so this: - increases pressure through V1 vasoconstriction - increase plasma volume through V2 - increase ACTH from pit

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12
Q

Describe how osmoreceptors regulate vasopressin?

A
  1. Increase in extracellular sodium
  2. Therefore movement of water out the osmoreceptor by diffusion
  3. Osmoreceptor shrinks
  4. This increases osmoreceptor firing
  5. More osmoreceptor firing leads to more AVP release from the hypothalamic neurones
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13
Q

Describe how the non-osmotic stimulation of Vasopressin works?

A
  1. stretch receptors in atrium detect pressure and INHIBIT RELEASE
  2. Therefore when the volume drops, the stretch receptors are stretched less, so LESS INHIBITION OF VASOPRESSIN
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14
Q

What might trigger the non-osmotic stimulation of Vasopressin Release?

A

Major haemorrhage

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15
Q

What are the benefits of vasopressin release following major haemorrhage?

A
  1. Increase the circulating volume
  2. Restore the blood pressure which will have dropped
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16
Q

How doe AVP trigger an increase in blood volume following haemorrhage?

A

Increased water absorption in the kidney via V2 receptor, therefore increasing blood volume and hence pressure as well

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17
Q

Which receptors does AVP initiate vasoconstriction through?

A

V1 receptors

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18
Q

What is the physiological response to water deprivation?

A
  1. Increased plasma concentration
  2. This stimulates the osmoreceptors to fire, leading to AVP release
  3. This stimulates water reabsorption from the renal collecting ducts
  4. Urine volume decreases, and the concentration of the urine increases as more water is kept
  5. This reduces the plasma concentration
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19
Q

What is the most common cause of polyuria, nocturia and polydipsia?

A

diabetes mellitus

20
Q

What are the common symptoms between Diabetes Insipidus and Diabetes Mellitus?

A

Polyuria
Polydipsia
Nocturia
Thirst

21
Q

What is the difference between Diabetes Insipidus and Diabetes Mellitus?

A

Insipidus is due to a problem with AVP, and mellitus is due to osmotic diuresis due to glucose affecting the urine

22
Q

What are the types of diabetes insipidus?

A

Cranial Diabetes Insipidus (VI) and Nephrogenic Diabetes (VR)

23
Q

What is VI?

A

A problem with the hypothalamus/pituitary which mean the patient is unable to make their own AVP - could be called vasopressin insufficiency

24
Q

What is VR?

A

when the patient makes AVP however the KIDNEY is unable to respond to it

25
Q

What are some causes of VI? (6)

A

TB
Pituitary surgery / tumours
Metastasis to the pituitary
Granulomatous infiltration of pituitary stalk
Autoimmune
Congenital

26
Q

What are the causes of VR?

A

mutation in V2 receptor / aquaporin type 2 water

acquired = drugs eg lithium

27
Q

What is the typical presentation of diabetes insipidus

A

Polyuria, nocturia, thirst and polydipsia

28
Q

What happens to the urine of a patient with diabetes insipidus?

A

Very dilute urine (hypoosmolar) and large volumes

29
Q

What happens to the plasma of a patient with diabetes insipidus?

A

plasma concentration increases and becomes hyper
osmolar, high salt serum and normal glucose as the patient becomes dehydrated as they are continually urinating

30
Q

what happens to the sodium concentration in the plasma of a patient with diabetes insipidus?

A

increases

31
Q

Why do patients with diabetes insipidus have polydipsia?

A

The AVP problem results in impaired concentration of urine in the renal collecting duct

Therefore large volumes of dilute urine are produced

Increases in plasma osmolarity and sodium

Stimulation of osmoreceptors, leading to polydipsia

32
Q

How can diabetes insipidus lead to death?

A

When the patient has polydipsia but no access to water -this
leads to dehydration and death

33
Q

What is psychogenic polydipsia?

A

When the patient drinks too much water, and so passes large volumes of water - no problem with AVP

34
Q

How do symptoms arise from psychogenic polydipsia?

A

Increased drinking leads to a fall in plasma osmolarity and less AVP being secreted by the posterior pituitary so more urine is secreted

35
Q

How do you distinguish between diabetes insipidus and psychogenic polydipsia?

A

Water deprivation test - No access to anything to drink - measuring urine volumes, urine and plasma conc

36
Q

What is the normal response to hours doing the water deprivation test?

A

The urine osmolarity increases as AVP helps to concentrate the urine

37
Q

During the water retention test, what is the difference between psychogenic polydipsia and diabetes insipitus?

A

In both the urine osmolarity increases - however the normal one is more than the psychogenic polydipsia

38
Q

Why is it important to measure the weight of the patient regularly?

A

Stop the test if they lose more than 3% of their total body weight

39
Q

What happens to the plasma and urine osmolarity in the water deprivation test for a patient with diabetes insipidus?

A

No change in the urine osmolality,

40
Q

How to distinguish between Cranial and nephrogenic DI?

A

give desmopressin or ddAVP

41
Q

What is the effect in CDI and NDI on giving them ddAVP?

A

Cranial - the urine osmolarity will increase as the synthetic AVP works like AVP

Nephrogenic - no increase in urine osmolarity with ddAVP as kidneys cannot respond

42
Q

What are the different presentations of desmopressin?

A

tablet or intranasal

43
Q

Desmopressin ( how is it made/ works)?

A

d enantiomer so isnt biodegrable (longer half life). This would replenish the deficiency in VI.

44
Q

What is SIADH
?

A

Syndrome of Inappropriate Anti-Diuretic Hormone

45
Q

What are the symptoms of SAIDH?

A

reduced urine output
increased water retention
High urine osmolality
Low plasma osmolality

46
Q

How is SIADH managed?

A

Restrict fluids
Use a vasopressin antagonist (Vaptan) which binds to the V2 receptors in the kidney so AVP doesnt work

47
Q

What happens to sodium levels in SIADH?

A

low sodium = hypoatrenaemia

ENDOCRINOLOGY (20 decks)

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