1_Dermoscopy_Pt 1 Flashcards
what are the layers of the skin?
epidermis, dermis, subcutaneous tissue

what are the layers of the EPIDERMIS?
- Basal (stratum germinativum) – deepest layer
- Prickle (stratum spinosum)
- Granular (stratum granulosum)
- Stratum lucidum** (**ONLY IN PALMS AND SOLES**) **(*KNOW FOR EXAM, “always a good test question”)
- Horny (stratum corneum) – most superficial layer

where in the body is STRATUM LUCIDUM found?
This layer of the epidermis is ONLY FOUND in the PALMS AND SOLES
what are the functions of the skin?
- cold/ heat/ radiation
- pressure/ blows/ abrasion
- action of chemical substances
- invasion by microorganisms
- heat & water loss
- defense against invading microorganisms
- absorption of certain substances
- perspiration
- circ and therm regulation (via derm vasc system)
- pressure/vibration/touch/pain/temp sensory organs

what is another name for the basement membrane?
why is it an area of research interest?
- Dermal-epidermal interface (basement membrane)
- area of research interest bc pathology here can cause visible skin disease
what is the anatomy of the DERMIS layer?
which sublayer has more collagen?
- Separated into _papillary and reticular l_ayer
- **the RETICULAR layer has a lot of collagen
- Place where hair and glands begin

what are the FUNCTIONS of the DERMIS layer?
- Temperature regulation through control of cutaneous blood flow and sweating
- Mechanical protection of underlying structures
which skin layer: consists of spongy connective tissue with energy-storing adipocytes
Subcutaneous or Subcutis layer:
- Consists of spongy connective tissue with energy-storing adipocytes (fat cells)

(T/F) The fat content of the subcutis is the same in all body regions and individuals.
- The fat content of the subcutis is NOT the same in all body regions and DIFFERS in men and women
- Zero fat in and around nail tissue
what is the fat content in and around the nail tissue?
- Zero fat in and around nail tissue
when in development does nail begin to develop?
between 10th-17th week in utero
is when the nail begins to develop
which cells make up the nail plate?
- Onychocytes: one of the tightly packed keratinized cells arranged in layers to make up the nail plate.
what is the nail plate comprised of, in general terms?
the nail plate is formed by mostly nail matrix – w/ some contribution from nail bed, shape contributed from matrix and phalanx
what is directly deep to the nail plate?
distal phalanx directly underneath nail plate;
there is NO SUBCUTANEOUS tissue
compare hair and nails w/ regards to:
- growth
- keratin content
- function
- assoc glands
- where


what are the key differences between APOCRINE and ECCRINE glands of the skin?

what is a sebaceous gland?
- Apocrine gland associated with hair follicle;
- aka Pilosebaceous unit
which glands are where ACNE occurs?
what causes these glands?
- Sebaceous glands are where acne occurs
- Sebaceous glands are caused by metabolic, environmental, etc factors
- can become colonized and then infected
which glands produce sebum?
what is the normal rate, and what decreases the rate?
- sebaceous glands produce sebum
- normal amount is 1mg/10cm2 every 3 hours
- Skin is dry if produces less than that amount

how long does it take for keratinocyte to pass from basal to corneal layer?
8-10 weeks for epidermal cell turnbover
describe the process of epidermal cell turnover
- Keratinocytes divide in basal cell layer, differentiate, and progress upwards to the stratum corneum (no nuclei in corneum)
- No cell division detected past the basal layer
where is no cell division detected past WHICH SKIN LAYER?
No cell division detected past the BASAL layer
what are the big 3 of the skin exam?
ASK
LOOK
PALPATE
What are examples of questions to ASK the patient when preventing for a skin exam?
FIRST, NLDOCAT
- Evolution (How did it begin? How did it change?)
- Involution (How did it go away?)
- What other body parts affected
-
History of rashes/skin cancer
- Topical med history (OTC/Rx/Folk/Home, failure or success?)
- Have you seen a dermatologist?
- Have you had a biopsy?
what factors should you consider when VISUAL AND TOUCH assessment?
(LOOK AND PALPATE)
- Distribution/location (where on the body?)
- Grouping/configuration
- Shape (primary or secondary lesions)
- Size (cm)
- Color (red, blue/cyanotic, pale)
- Temperature (use backs of hands/fingers to determine if cool or warm)
- Mobility (does it lift up?) and turgor (the speed to which it returns to normal)
- Nails
- The skin around the lesions (especially with wounds)
- Moist or dry (wetness or flakes?)
- CHECK THE HANDS!!!
which configuration is “Blisters on a red base” or “Dew drops on a rose petal”?
Herpetiform configuration,
often assoc w/ VIRAL distribution
geographic distribution usually indicates what condition?
psoriasis
what is the following configuration?

- wood grain
- usually malignant, and VERY RARE
what is the pigmentation of a new scar?
- New scar is usually darker than skin color (hyperpigmented) and gets lighter as it progresses
how would you describe a blue lesion?
red lesion?
- cyanic is blue
- erythematous is red
how do you describe: reddish brown, scaly papules on the palms and soles?
COPPER PENNY LESIONS;
plane lesion:
define
lesions that are FLUSH WITH SKIN;
eg. macule and patch
what is a “flat, non palpable lesion smaller than 1 cm”
macule

what is a “flat, non-palpable lesion LARGER THAN 1 CM”?
Patch
(aka macule > 1 cm)

what is: a “circumscribed, solid elevations with NO visible fluid from a pinhead size to 1cm”

PAPULE,
an elevated lesion < 1 cm
what is a “circumscribed, solid elevation with NO visible fluid that is LARGER THAN 1 CM in diameter”?
nodule,
elevation; aka papule > 1 cm

what is the following derm condition?

“TOASTED SKIN SYNDROME”;
- Multiple macules, with both hypopigmentation and hyperpigmentation
- From infrared radiation
what is: “an elevated mass 2cm or more in diameter”

tumor
what is: “an elevated confluence of papules or a broad papule, 1cm or more in diameter”

plaque;
(more geographic than dome shaped)
what is: “edematous elevations of various sizes that DO NOT last more than 24 hours”
wheals or hives;

these are not permanent; “when doing an injection, raise a wheal”
which skin elevation involves “dermal hardening and thickening”?

INDURATION

define: heat urticaria
hives after exercising
what is: a “circumscribed fluid-filled elevations 1mm to 1cm in size, can be serous, purulent, sero-sanguinous filled”
VESICLE, or small blister
what is a: “circumscribed fluid filled elevations LARGER THAN 1 CM in size, can be serous, purulent, sero-sanguinous filled”

Bulla, or big blister
what is: a “circumscribed fluid filled elevations 1mm to 1cm in size, with purulent material in them”
*does not have to be a sign of infection, does not have to be bacteria-filled

PUSTULE;
aka a vesicle w/ purulent material
what is: “dry or greasy skin flakes”?

SCALE

what is: “a horny projection from skin** (**calluses and warts)”

KERATOSIS
what is: “a heap of dried plasma, WBC, RBC”

CRUST,
(crust = scab, if dried fluid)
what is “tissue necrosis”?
what is “dried fluid”>

- ESCHAR is tissue necrosis (right)
- CRUST is dried fluid (left)
what is: “a depression below skin level; loss of part or all EPIDERMIS (burn)”

EROSION
(there is NO SCAR with loss of epidermis)
what is: “a depression below the skin level with LOSS OF EPIDERMIS AND PART DERMIS”

ULCER:
- If you lose part of dermis, you will scar
what are the 3 types of skin openings?
(meaning there’s a break WITHOUT LOSS OF EPIDERMIS)
- fissure
- burrow
- cyst
what is: “an opening in which a linear cleft through the epidermis which may go into the dermis (think chapped lips)”

FISSURE
what is: “an opening with narrow, elevated tortuous tunnel produced by a parasite”

BURROW;
such as from CLM (cutaneous larva migrans)
what is: “an opening, circumscribed lesion with a wall AND a lumen, may contain fluid or solid matter”

CYST
- Elevations that have lumen (opening) and also a wall
- Usually start as ingrown hair or some foreign body
- Have to remove wall by excising it to fully remove it
what is: “a punctate or linear abrasion produced by mechanical means usually to epidermis”

EXCORIATION
what is: “an appearance of surface softening due to constant wetting”

MACERATION
what is: “flat topped thickening of skin induced by scratching, skin lines are accentuated”

LICHENIFICATION
what is: “a depression in the skin resulting from thinning of the epidermis or dermis”

ATROPHY
what is: “dilated superficial blood vessels, blanch with pressure”

TELANGIECTASIA
what is: “greater than 5mm, less than 1cm.
Do not blanch with pressure**, **extravasation of blood cells into dermis”

PURPURA
what is: “less than 5mm.** **Do not bland with pressure**, **extravasation of blood cells into dermis”

PETECHIAE
what are the 3 zones of a target lesion?

- bull’s eye dark center,
- pale zone,
- rim of erythema (most common is erythema multiforme)
what are the differences between a hypertrophic scar and a keloid scar?
