18 Polyarticular JIA

Question 1

Most prevalent category of JIA worldwide

Answer 1

Oligoarticular JIA

Question 2

2nd most prevalent category of JIA worldwide

Answer 2

RF- polyJIA

Question 3

Most frequently reported categories of JIA in southeast asia

Answer 3

sJIA and ERA

Question 4

Exclusion criteria for PolyJIA

Answer 4

1) Psoriasis or hx of psoriasis in the patient or 1st degree relative
2) HLA-B27 (+) male after 6th birthday
3) Spondyloarthropathy in the patient or 1st degree relative
4) sJIA

Question 5

T/F Breastfeeding has been well-established as a protective factor against polyJIA

Answer 5

F

Question 6

Environmental factors invoked as risk factors for development of polyJIA

Answer 6

1) Maternal smoking
2) Maternal infection during pregnancy
3) Stressful life events

Question 7

3 distinct phenotypes of RF- polyJIA

Answer 7

1) Similar to adult onset RF- RA: Later onset, symmetrical, elevated acute phase reactants, ANA (-)
2) Similar to extended oligoarticular JIA: Younger onset, asymmetrical, normal to mildly increased APR, ANA (+), increased risk of anterior uveitis
3) Dry synovitis: Normal APRs, poorly responsive to treatment, substantial joint damage

Question 8

Variant of RF-negative polyJIA that can mimic genetic and metabolic diseases such as Farber disease and mucopolysaccharidosis

Answer 8

Dry synovitis

Question 9

T/F TMJ is commonly affected in children with polyJIA

Answer 9

T

Question 10

Growth disturbance of the TMJs are more likely to occur when inflammation starts when

Answer 10

Before 8 years old

Question 11

Gold standard for detection of active inflammation of TMJ

Answer 11

MRI with contrast

Question 12

Proposed category to include RF- arthritis regardless of # of involved joints

Answer 12

PolygoJIA

Question 13

Chronic asymptomatic uveitis is most common in which JIA categories

Answer 13

1 (MC) Oligoarticular JIA

#2 RF- polyJIA

Question 14

T/F RF- polyJIA is NOT typically associated with overt cardiovascular pathology

Answer 14

T