18 - Motor Pathways II Flashcards

1
Q

Brainstem Pathway LMN are…

A
  • Cranial Nerve Nuclei
  • Ipsilateral to exit from CNS
    • So, LMN signs are ipsilateral to damage
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2
Q

Corticobulbar UMNs controls which nuclei, and which does it not?

A
  • Only fucks with SVE, GSE;
    • Controls all SVE + 12
    • Does not control any GSE except for 12
  • Controls:
    • Trigeminal motor nucleus (jaw)
    • Facial nucleus (facial expression)
    • Nucleus ambiguus (larynx, pharynx, and palate)
    • Hypoglossal nucleus
    • Accessory nucleus
  • DOES NOT CONTROL EYES
    • Oculomotor nucleus
    • Trochlear nucleus
    • Abducens nucleus
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3
Q

CN Nuclei with unilateral corticobulbar inputs

A
  • Facial nucleus (7)
    • Neurons that innervate the lower quadrant of the face only receive unilateral, contralateral input
  • Hypoglossal nucleus (12)
    • Neurons that innervate tongue only receive unilateral, contralateral input
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4
Q

Unilateral corticobulbar lesion effect

A
  • Generally do not produce clinical symptoms because most CN nuclei are bilaterally supplied by CBS
  • WIll show CN 7 (opposite lower quadrant of face) and CN 12 (opposite half of tongue) paresis
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5
Q

Eye movement control UMNs

A
  • NOT FROM M1
  • Corticopontine fibers from fronal eye field and parietal eye field
  • Activate CPGs controlled by superior colliculus
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6
Q

Corticobulbar fibers exit where for which cranial nerves?

A
  • PONS: 5, 7
  • MEDULLA: 9, 10, 12
  • FORAMEN MAGNUM (to SC): 11
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7
Q

GSE CN Nuclei innervation

A

Paramedian branches

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8
Q

CN 12 Function, Innervation, Location, Lesion

A
  • GSE nucleus in medulla
  • Innervated by ASA paramedians
  • Nerve comes out in pre-olivary sulcus
  • Functions:
    • Extrinsic tongue muscles:
      • Geniglossus: protrusion
      • Styloglossus: retraction
      • Hypoglossus: depression
    • Intrinsic tongue muscles control shape
  • Lesions:
    • Nucleus or nerve = tongue points to side of lesion due to intact genioglossus
    • Supranuclear = tongue points to opposite side of lesion
    • BE CAREFUL: you can’t tell just from the tongue which side/level is lesioned!
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9
Q

Abducens Nucleus Function

A
  • Innervates lateral rectus, muscle that abducts the eye on each side
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10
Q

Trochlear Nerve Function

A
  • Innervates superior oblique of eye CONTRALATERAL to nucleus
    • L nerve from R nucleus makes L eye tilt inward and downward
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11
Q

Oculomotor Nerve Function

A
  • Innervates every other movement besides abduction and inward/downward tilt
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12
Q

Eye Muscles, CNs, Directions

A
  • To look straight up: superior rectus (to move the eye up), and inferior oblique to counteract torsion
  • To look straight down, inferior rectus moves the eye down, superior oblique counteracts torsion
  • If eye is abducted (AWAY from nose), you’re fully in line with the rectus, so you don’t use the obliques to counteract anything
  • You may also use superior or inferior rectus to look up or down, but still no obliques because there’s no torsional movement introduced
  • If eye is looking to midline (converging), you do not use rectus at all; just superior oblique and inferior oblique to control
  • You only use the superior oblique when you’re looking down at near objects (trochlear nerve!)
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13
Q

Conjugate Gaze vs Intorsion/Extorsion

A
  • Elevation of gaze: eyes look upward
  • Depression of gaze: eyes look downward
  • Horizonal conjugate gaze: both eyes look L or R
    • One eye adducts (CN 3), one eye abducts (CN 6)
  • Extortion: R eye movement when head tilts L
  • Intortion: R eye movement when head tilts R
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14
Q

CN VI Palsy

A
  • Lesion to actual nerve of CN 6
  • Palsy of ipsilateral lateral rectus muscle
  • Eye on affected side drifts medially during forward gaze
  • Eye on affected side fails to abduct past midline on horiztonal conjugate gaze to the affected side
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15
Q

Trochlear Nerve Muscle

A
  • Superior oblique
  • Critical for binocular vision
  • When eye is abducted, SO depresses the eye
  • When eye is adducted, SO intorts the eye
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16
Q

CN IV Palsy

A
  • CN IV nerve lesion results in paralysis of ipsilateral superior oblique muscle
  • Pt has diplopia = double vision that’s worse when looking down and medially
  • Loss of SO intorsion (so eye extorts)
  • Pts typicalkly tilt head forward and to non-lesioned side to comensate
  • Lesion to nucleus = contralateral signs (but extremely rare)
  • Lesion to nerve = ipsilateral signs
17
Q

Oculomotor Nerve Function, Location

A
  • Functions
    • Eye movement (GSE)
    • Pupil constriction (GSE)
    • Eyelid (this is GVE - levator palpebrae superioris, Edinger-Westphal))
  • Nuclear complex is in basilar territory in midbrain (posterior to MLF); but nerve goes out laterally (PCh.A) before returning to midline (basilar)
  • Peripheral course of nerve runs parallel with PCOM, so is vulnerable to PCOM aneurysms
18
Q

Third Nerve Palsy

A
  • CN 3; AKA Down and Out syndrome
  • Abducted eye (loss of medial rectus)
  • Depressed eye (loss of superior rectus and inferior oblique)
  • Complete ptosis (loss of levator palpebrae superioris)
  • Ipsilateral mydriasis (dilated pupil) - loss of constrictor pupillae
  • Loss of direct, consensual pupillary light reflexes in the ipsilateral eye
19
Q

Internuclear Ophthalmoplegia

A
  • Lesion to MLF on one side
  • Eye ipsilateral to lesion cannot adduct when looking opposite of lesion
  • Contralateral eye shows nystagmus since vestibular signals require MLF
    • Oscillatory nystagmus directed at midline for as long as the eye continues to
  • Ex: R-sided MLF lesion, asked to look to L.
    • R eye cannot adduct, L eye can abduct
    • L eye shows nystagmus as long as looking to left
20
Q

Parinaud’s Syndrome

A
  • Issue with vertical conjugate gaze (main center is in rostral midbrain)
  • Lesions that affect rostral dorsal midbrain lead to paralysis of upward vertical gaze; eyes point downwards
21
Q

Burst Neurons

A
  • Goal of burst neurons is to get III, IV, VI to move
  • Paramedian Pontine Reticular Formation (PPRF)
    • Horizontal saccades
    • Near MLF in pons
    • Burst neurons for VI nuclei
  • Rostral interstitial nucleus of MLF (riMLF)
    • Vertical saccades
    • Within MLF in upper midbrain
    • Burst neurons for III, IV nuclei
22
Q

Neuron Integrators

A
  • Activated by burst neuron collaterals to keep eye in eccentric gaze
  • Generate step signals
  • Nucleus Prepositus Hypoglossi (ppH)
    • Horizontal saccades
    • Located near MLF in medulla
  • Interstitial nucleus of Cajal
    • Vertical saccades
    • Small nucleus within MLF
23
Q

Frontal vs Parietal Eye Field Inputs

A
  • FEF
    • Contralateral voluntary saccadic eye movements
    • Contralateral smooth pursuit
    • Bilateral vergence eye movements
  • PEF
    • Visual-evoked saccades (Reflexive)
    • Smooth pursuit
24
Q

Omnipause Neurons

A
  • Clusters of pontine reticular neurons
  • Fire continuously (except just prior to and durring saccades)
  • Pattern generators for saccadic eye movements
  • When eyes are at resting state, omnipause neurons inhibit burst neurons
    • PPRF = horizontal
    • riMLF = vertical
25
Q

Horizontal Saccade Components

A
  • Burst neuron = Paramedian pontine reticular formation (PPRF)
    • Located near MLF in pons
  • Neural inegrator = Nucleus prepositus hypolgossi (ppH)
    • Located near MLF in medulla
26
Q

Vertical Saccade Components

A
  • Burst neurons = Rostral interstitial nucleus of MLF (riMLF)
    • Located in MLF
  • Neural integrator = Interstitital nucleus of Cajal
    • Located in MLF
27
Q

CN susceptible to PCOM aneurysms

A

CN 3

28
Q

Horizontal Conjugate Gaze Deficits

A

VI Nucleus Damage

29
Q

Near Response Cells

A
  • Provide input to CN 3 for vergence
  • Drive the near triad (synkinesis) sequence by activating GVE Edinger-Westphal nucleus
    • Eye convergence (CN 3)
    • Lens accomodation (EW)
    • Miosis/pupillary constriction (EW)
  • Allows for convergence in the setting of MLF damage
30
Q

Synkinesis

A
  • AKA Near triad
    • Eye convergence (CN 3)
    • Lens accomodation (EW)
    • Miosis/pupillary constriction (EW)
  • Initiated by near response cells
  • Allow for vergence in the absence of MLF
31
Q

CN XI Palsy

A
  • Accessory nucleus = sternocleidomastoid & trap
  • Loss of trapezius action
    • Winging of the scapula
    • Loss of shoulder profile
    • Difficulty raising the arm above shoulder level
  • Loss of SCM action:
    • Pt’s head will be permanently turned to the damaged side (Torticollis: “wry-neck”)
32
Q

Torticollis

A
  • Symptom of CN XI palsy
  • Pt’s head permanently turned to damaged side
33
Q

Pre & Post-olivary sulcus CN exits

A

Pre-olivary sulcus

  • CN 12 leaves

Post-olivary sulcus

  • CNs 9, 10, 11 leave
34
Q

Gag Test

A
  • Involves only cranial nerves 9 and 10, but uses the spinal nucleus of 5 as an intermediate neuron
    • SN5 sends neuron 2 axons containing 9, 10 sensory info to nuclei ambiguus via the VTT
  • Promotes gag
35
Q

Facial Nucleus Location, Innervation, Lesion

A
  • Located in pons
  • Innervated by AICA
  • Axons:
    • run dorsally AROUND abducens nucleus (creating a facial colliculus)
    • Are innervated by basilar paramedians
  • Lesions:
    • UMN lesion = contralateral lower quadrant palsy (because lower quad of face has unilateral input only)
    • Nucleus/nerve = ipsilateral facial hemiplegia (Weakness) & noise sensitivity
36
Q

Eight and a Half Syndrome

A
  • Lesion at the facial colliculus, floor of the 4th ventricle
  • 3 structures affected because they’re closely associated:
    • Abducens nucleus = conjugate gaze
    • MLF = internuclear ophthalmoplegia (INO)
    • Facial nerve axons = facial muscles
  • So, for a right-sided facial colliculus area lesion, pt suffers:
    • R Horizontal conjugate gaze palsy (6 nucleus) = 1
    • L-sided INO = 1/2
    • R Facial nerve 7 palsy (hemiparesis) = 7
      • Sums to 8 1/2
37
Q

Corneal Blink Reflex

A
  • THE pontine reflex
  • Involves facial nucleus (motor supply to orbicularis oculi) and the rostral spinal trigeminal nucleus (afferent V1)
  • Nociception from the cornea is carried by A∂ and C fibers in the long ciliary branches of V1 (ophthalmic) and relayed by trigeminal ganglion neurons
    • Spinal nucleus bilaterally signal the facial nucleus
    • Facial nucleus (efferent CN 7) causes both eyes to blink
  • Reflex is fast (mostly influenced by A∂ fibers)
  • Is consensual in that both eyes blink from unilateral stimulation of the cornea
38
Q

Pseudobulbar Palsy

A
  • Bilateral damage to corticobulbar fibers to CN motor nuclei
  • Symptoms (UMN weakness):
    • Dysarthria: speech problems
    • Dysphagia: swallowing problems
    • Inappropriate outburst of laughter, crying because emotional inputs to CN motor nuclei from limbic system are intact
  • Causes
    • Vascular event (bilateral internal capsule infarcts are most common)
    • Demyelinating disorders (like multiple sclerosis)
    • Amyotrophic lateral sclerosis (ALS)
    • High brainstem tumors
    • Trauma
39
Q

Locked-In Syndrome

A
  • Damage to basal pons = bilateral cortcibulbar AND corticospinal damage
    • Results in complete paralysis of all voluntary muscles = interfering with facial expression, speech, movementSparing of CN III may allow some vertical eye movement and eyelid movement
      • But not horizontal eye movement (bc CN 6 is in pons)
    • Pt is awake, aware of surroundings because somatosensory pathways and brainstem reticular formation are usually spared
  • Causes
    • Basilar artery infarct
    • Brainstem hemorrhage involving basilar artery
    • ALS may also cause this