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3: MED2 Y3 - Gastrointestinal [7] > [16] Other Gastric Neoplasms > Flashcards

[16] Other Gastric Neoplasms Flashcards

1
Q

Give 5 benign neoplasms of the stomach

A 
Benign polyps
Leiomyoma
Lipomas
Haemangiomas
Schwannomas
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2
Q

Give 3 malignant gastric neoplasms

A

Lymphoma
Carcinoid
GIST

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3
Q

What is the most common mesenchymal tumour of the GIT?

A

Gastrointestinal stromal tumour

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4
Q

What % of gastrointestinal stromal tumours occur in the stomach?

A

> 50%

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5
Q

When do gastrointestinal stromal tumours occur?

A

About 60 years

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6
Q

What genetic condition has an increased incidence of gastrointestinal stromal tumours?

A

Neurofibromatosis type 1

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7
Q

Where do gastrointestinal stromal tumours arise from?

A

Intestinal cells of Cajal

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8
Q

Where are the intestinal cells of Cajal located?

A

In the muscularis propria

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9
Q

What is the function of the intestinal cells of Cajal?

A

Pacemaker cells

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10
Q

What is found on OGD in gastrointestinal stromal tumours?

A

Well-demarcated spherical mass with central punctum

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11
Q

What causes the presentation of gastrointestinal stromal tumours?

A

Mass effects

Ulceration

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12
Q

What symptoms are caused by mass effects in gastrointestinal tumours?

A

Abdominal pain

Obstruction

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13
Q

What symptoms are caused by ulceration in gastrointestinal stromal tumours?

A

Bleeding

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14
Q

What are the poor prognostic factors in gastrointestinal stromal tumours?

A

Large size
Extra-gastric location
Increased mitotic index

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15
Q

What is involved in the medical management of gastrointestinal stromal tumours?

A

Imatinib

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16
Q

What is imatinib?

A

A kit selective tyrosine kinase inhibitor

17
Q

When is medical management used in gastrointestinal stromal tumours?

A

In unresectable, recurrent, or metastatic disease

18
Q

What is involved in the surgical management of gastrointestinal stromal tumours?

19
Q

What are carcinoid tumours?

A

A diverse group of neuroendocrine tumours of enterochromaffin cell origin

20
Q

What might carcinoid tumours secrete?

A

Multiple hormones

21
Q

What % of carcinoid tumours occur in the stomach?

22
Q

How do gastric carcinoids arise?

A

Atrophic gastritis leads to decreased acid production, so increased gastrin, so ECL hyperplasia, leading to a carcinoid tumour

23
Q

What other tumour might develop into a carcinoid tumour?

A

Gastrinoma

24
Q

What is the most common type of gastric lymphoma?

25
Q

What causes a MALToma?

A

Chronic H. Pylori gastritis

26
Q

What is sometimes curative in MALToma?

A

H. Pylori eradication

3: MED2 Y3 - Gastrointestinal [7] (44 decks)

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