16. Clinical Approach to Headache Flashcards

1
Q

Primary HAs are benign disorders while secondary headache are a sign of organic disease. A headache history is important to determine the cause, along with pain, prodrome (aura, muscle aches, fatigue), associated symptoms, behavior such as pacing rocks or retreats to a?

A

Dark, quiet room

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2
Q

Along with characterizations of the HA, ask about previous medications used, surgical history, family/social history, good general exam including vitals, cardiac status, extracranial structures, ROM and presence of pain in the?

A

C Spine

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3
Q

HA neuro exam includes neck flexion, bruits over head and neck, optic fundi, pupils, visual fileds, cranial nerve exam, motor power in limbs, muscle reflexes, plantar responses, sensory exam, coordination and ?

A

gait

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4
Q

Some worrisome signs of a pathological HA includes, “worst HA”, onset of HA after age 50, atypical HA for pt, HA with fever, abrupt onset, subacute HA with progressive worsening over time**, drowsiness, confusion, memory impaired, weakness, ataxia, loss of coordination, paresthesias, sensory loss, paralysis and an abnormal medical or?

A

neuro exam

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5
Q

What is inflammation of the meninges surrounding the brain and SC, sometimes with assoc encephalitis (brain tissue inflam), typically caused by virus or bacteria, but other rare causes are possible?

A

Meningitis

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6
Q

What kind of meningitis can progress quickly to become serious with complications including hearing loss, memory difficulty, learning disabilities, brain damage, gait problems, seizures, kidney failure, shock or death, MCC in adults infants and young children is *****Streptococcus Pneumoniae?

A

Bacterial meningitis

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7
Q

H. Influenza used to be the MCC of bacterial menginigits in children but the vaccine has decreased that, N. meningitidis is a high contagious cause in teenagers and young adults in close quarters, what is the MC bacterial meningitis in the elderly?

A

Listeria Monocytogenes

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8
Q

Viral meningitis is usually benign and MC due to enteroviruses, HSV, HIV and west nile. What type fungal meningitis can be acute or chronic, smoldering over months to years, esp in DM and immunocompromised?

A

cryptococcal meningitis is the MC** in DM older than 50

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9
Q

Note: if there is a pos Gram stain on CSF in adults, continue dexamethason and add a *targeted antimicrobial, if there is a neg gram stain on CSF in adults, continue dexamethasone and start a?

A

embiric antimicrobial therapy

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10
Q

Signs and symptoms of meningitis in pts over the age of 2 include sudden high fever, stiff neck, severe headache that seems different than normal, headache with N/V, confusion or difficulty concentrating, seizures, sleepiness, sensitivity to light, no appetite or thirst, and?

A

Skin Rash (meningococcal meningitis)

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11
Q

Signs and symptoms of meningitis in newborns includes high fever, constant crying*, excessive sleepiness, irritability, inactivity or slugishness, poor feeding, stiffness in babys body/neck and a bulge where?

A

in the soft spot on top of a baby’s head (fontanel)

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12
Q

With bacterial meningitis suspicion, if there is immunocompromise, hx of CNS disease, new onset seizure, papilledema, altered consciousness, or focal neurologic deficits or delay in performance of dx LP, what should NOT BE DONE?

A

Lumbar Puncture (just do blood cultures STAT)

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13
Q

IDSA defines encephalitis as the presence of inflam process of the brain in assoc with clinical evidence of neuro dysfunction, of the pathogens reported to cause encephalitis, the majority are what?

A

Viruses are MCC of Infectious encephalitis**

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14
Q

Infectious encephalitis is caused by viruses, in an adult it is commonly caused by HSV1 or 2, HIV, West nile, Varicella zoster and?

A

treponema pallidum

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15
Q

What viral encephalitis presents as rapidly progressive neurologically devestating illness with combination of fever, HA, impaired consciousness, seizures, and focal neuro symptoms, MRI/EEG = focal abnls in TEMPORAL lobes, tx with acyclovir, 1/4th develop recurrent neuropsychiatiric symptoms?

A

Herpes Simplex 1 Encephalitis

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16
Q

Autoimmune causes of encephalitis commonly mimic infectious encephalitis, most autoimmune causes are associated with seizures, intractable epilepsy, and should be considered in pts with rapidly progressive (less than 6 weeks), encephalopathy or psychiatric disturbance, especially if what is present?

A

SEIZURE (+/- fever)

PROMPT ID of suspected AI cause with initiation of treatment is important

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17
Q

Autoimmune Encephalitis are typically treated with a combination of high dose steroids, IVIg, plasma exchange, rituximab, cyclophosphamide or other immunosuppressants, the 2 MC etiologies of AI encephalitis include LGI1 = leucine rich glioma inactivated encephalitis and NMDA which is?

A

Anti-N-Methyl-D-Aspartate Encephalitis

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18
Q

NMDA Encephalitis MC affects young or middle aged WOMEN and presents with rapid onset (<3mo) of at least four of the 6 folloiwng sx…. 1) abnormal behavior/ cognitive dysfunction 2) speech dysfunction 3) seizures 4) movement disorders/dyskinesias/rigidity 5) 6)?

A

5) decreased level consciousness

6) Autonomic Dysfunction or central hypoventilation

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19
Q

NMDA Encephalitis will have at least one of the following lab study results: abnormal EEG (focal/diffuse slow/ disorganized activity, epileptic activity, or EXTREME DELTA BRUSH), or CSF showing pleocytosis, or NMDA receptor antibodies and or what?

A

Oligoclonal Bands

20
Q

Although NMDA Encephalitis patients can present w severe deficits, many will improve with aggressive treatment, though improvment may take a long time (1 yr), note that NMDA Encephalitis is commonly associated with the pesence of what type of tumor?

A

TERATOMA

21
Q

LGI1 Encephalitis occurs MC in MEN**, and typically involves faciobrachial dystonic seizures which are breif involving one side of the face and the arm on the same side, often occuring frequently, sometimes 100s of times a day, they do not respond to antiepileptic drugs alone and may require what to abate?

A

Immunotherapy

22
Q

LGI1 Encephalitis is seen with sleep disturbance in 50% of pt, may see temporal lobe abnl in some pts acutely, failure to ID and treat patients early results in permanent brain injury with longterm cognitive deficits, and short term memory problems, up to 1/3 of pts may what after treatment?

A

MAY RELAPSE

23
Q

Dx eval includes lab testing, neuro tests, WSR, TSH, CBC, glucose, CT, MRI, MRA, EEG, LP, ateriogram, dental, ENT, allergy eval. Drs think any person with HA should have a one time thorough imaging study (CT with and without or MRI) of the head, patients with a worrisome* history or abnl examination need urgent imaging and perhaps even?

A

LP and ateriogram

24
Q

Primary HA disorders are commonly due to common migraine (WITHOUT AURA), classic migraine (with aura), chronic migraine, tension-type HA and?

A

Cluster headache

25
Q

What type of migraine has mod/severe intensity, inhibits daily activites, age onset teens to early 20s, peak at 34-40, F:M 3:1, have 1-4 attacks per month, duration 4-72 hours (usually 12-24), usually unilat or bilat throbbing, sharp pressure, with prodrome (myalgia/cravings/yawning/mood changes), post drome fatiue irritability and fog, and behavior during is to retreat to dark quiet room, NO AURA?

A

Common Migraine

*Note: 80-90% migraine sufferes do not experience an aura

26
Q

Common Migraine assoc sx MC include nausea, vomiting, photophobia, phonophobia and less common, diarrhea, red eye, stuffy nose, lacrimation, miosis, and ptosis, what is the most common?

A

NAUSEA in 90%

27
Q

What type of migraine has all of what the common migraine has, but also has an aura which is usually 15-30 mins but sometimes longer and is commonly visual symptoms (scintillations (flash in vision), scotoma-often hemianopic (loss vision) ) but can be anything neurological?

A

Classic Migraine

28
Q

What type of migraine includes all the criteria for common migraine, but ALSO have a normal headache 15 or more days per month, headache lasting 4hours or longer for a period of at least 3 months, not attributed to another disorder?

A

Chronic Migraine

Neurogenic Inflammation is cause of migraine from trigem activation

29
Q

What type of HA has mild to mod intensity, does not prohibit daily activities, onset varies but peak at 20-40, F:M 3:2, episodic type is less than 15 d per month, chronic type is >15d per month, episodic lasts several hours, chronic lasts all day waxing and waining, located bifrontal, bioccipital, neck, shoulders, band like, described as dull, aching, squeezing, pressure, with no prodrome or aura, behavior not affected?

A

Tension Type HA (80% of chronic tension headaches are usually chornic migraine)

30
Q

What type of HA is severe excruciating pain which prohibits daily activities, onset is 20-50s, F:M 1:6** (MC in men), assoc w obstructive sleep apnea, episodic type is 1+ attacks/day for 6-8weeks, chronic is several attacks per week without remission, last 30-2hr, ***100% are unilateral, generally orbitotemporal?

A

Cluster HA

31
Q

Cluster HA are described as nonthrobbing, excruciating sharp boring and penetrating pain, prodrome may include breif mild burning in ipsi inner canthus or internal nares, no aura, behavior is frenetic, pacing, rocking, assoc sx include ipsi ptosis, miosis, conjuctival injection, stuffed or runny nose and ***?

A

Lacrimation / teary eyes

32
Q

Triggers for HA include hormones (estrogen) such as menses, ovulation, HRT and OCs, diet such as alcohol, chocolate, aged cheese, MSG, aspartme, caffeine, nuts, nitrates, citrus fruits, changes in weather/season/travel/schedule/sleep/diet/skipping meals, sensory stimuli (bright/flickering lights or odor), and MC?

A

Emotional Stress ***

33
Q

Tx for migraines include OTC analgesics, NSAIDs (naproxen/ketorolac/diclofenax), isometheptene (midrin), butalbital, opioids, DHE (dihydroergotamine) nasal spray and MC?

A

Triptans

suma, zolmi, nara, riza, almo, frova, ele

34
Q

Triptans are contraindicated in ischemic heart disease, CV/cerebrovascular/peripheral vascular disease, raynauds syndrome, uncontrolled HTN, hemiplegic or basilar migraine, severe renal or hepatic impairment, use within 24hr of tx with ergotamines, MOAIs, or other?

A

SSRI*** 5HT1 agonists

SEROTONIN SYNDROME

35
Q

Which triptan is one tablet at onset of HA, onset action in 60mins, LONGEST half life and Fewest SE of all triptans, contraindicated in pt with hepatic or renal impairment?

A

Naratriptan

36
Q

Sumatriptan comes in tablets, nasal spray or injection SQ, eletriptan should NOT be taken in 72hr of taking ketoconazole, itraconazole, nefazadone, troleandomycin, clarithromycin, vitonavir or nelfinavir… Remember– if one triptan doesnt work, try another- or do a different constituion such as?

A

injectable or NS

37
Q

If N/V is major feature of migraines consider using antiemetics (metoclopramide/prochlorperazine), if insomnia is major ft consider diazepam/temazepam or major tranquqilizer (thorzine) to help patient?

A

sleep off the migraine

prednisone taper can be used to break cycle of prolonged migraine (adjunct)

38
Q

In general if pt is experiencing more HA per weak consider a preventive mediaction to decrease freq and severity which include antidepressants like TCAs, SSRIs, SNRIs, MAOIs, B blockers, CCBs, anticonvulsants, ergot alkaloids, NSAIDs muscle relaxants, methysergide… What is the ONLY FDA approved treatment for chronic migraine?

A

BOTOX injections 155 units into 31 sites q3mos

39
Q

Non-rx tx of migraine includes exercise, stop smoking, HA education, riboflavin, magnesium (menstrual migraine), biofeedback, relaxation and stress management (best for migraine/tension HA). Acute Tx for Tension HA includes OTC analgesics, NSAIDs, opioids, Midrin, preventatives include TCAs/SSRIs/MAOIs, botox, ergot, M relaxants and?

A

anticonvulsants

40
Q

Acute tx of cluster HA is DHE (dihydroergotamine) 1mg- IM, lidocaine, narcotics, Oxygen, suma SQ/zolmitriptan NS (MC with fastest onset), preventative include anticonvulsants (valproic acid), lithium, indomethacin, prednisone, erogtamine tartrate, and what calcium channel blocker**?

A

Verapamil

41
Q

What HA disorder is excruciating sharp, shooting electrical quality pain occuring in paroxysm often frequent throughout the day, with treatment being carbamazepine or oxcarbazepine?

A

Trigeminal Neuralgia

42
Q

What is a group of HA cahracterized by unilateral trigeminal distribution pain that occurs in assoc with prominent ipsilateral cranial autonomic functions includes cluster HA (MC), paroxysmal hemicrania, hemicrania contrinua and SUNA syndrome….

A

NO

43
Q

What syndrome is shortlasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing, excruciating burning stabbing electrical HA in periorbital area lasting a few mins freq throughout the day, usually men over 50, tx is anticonvulsants (lamotrigine)?

A

SUNCT Syndrome - (same as cluster except cluster lasts 45 mins) SUNCT is only few mins**

Tx with Lamotrigine

44
Q

What is very similar to cluster headache (unlateral, periorbital, severe, exruciating, often with lacrimation and conjunctival injection but SHORTER duration (mins) and increased frequency (5x per day)– RESPONSIVE TO INDOMETHACIN ONLY?

A

Paroxysmal Hemicrania

45
Q

Treatment for a non-immunocompromised adult patient with bacterial meningitis (S. Pneumo) involves IMMEDIATE IV administration of steroids (dexamethasone), 3rd generation cephalosporin like CEFTRIAXONE and ?

A

vancomyocin - all IV

46
Q

IF you think there may a chance that the meningitis is VIRAL, then add WHAT to the IV steroids, vanco, and ceftriaxone?

A

Acyclovir

47
Q

If pt is unconscious, grabs side of their head and then collapses suddenly, has a stiff neck, dilated pupil, seizure, or weak on one side of the body, do a CT immediately and if nothing is seen do LP (10-15% found this way), what should be expected?

A

Rupture of Cerebral Hemorrhage