16/03/22 Flashcards
Which of the following is a common cause of renal disease in children, and needs to be considered during your paediatric rotation?
- Diabetic Glomerulosclerosis
- Membranous GN
- Focal and Segmental GN
- Minimal change glomerulonephritis
- Goodpastures syndrome
Minimal change glomerulonephritis
Which of the following is useful in an acute attack of gout?
- Allopurinol
- Colchicine
- Aspirin
- Probenecid
- Bendrofluazide
Colchicine
Which of the following genetic syndromes does not put you at risk of phaeochromocytoma?
- VHL (Von Hippel Lindau)
- NF1 (Neurofibromatosis type 1)
- MEN1 (Multiple Endocrine Neoplasia type 1)
- MEN2 (Multiple Endocrine Neoplasia type 2)
- MEN3 (Multiple Endocrine Neoplasia type 3)
MEN1
Which drug can be used in the treatment of benign prostatic hyperplasia (BPH)?
- 5-alpha reductase inhibitor
- Oestradiol
- Phosphodiesterase inhibitor (can you name one?)
- Beta blockers
- Testosterone
5-alpha reductase inhibitor
Which of these is a Gram positive organism?
- E-coli
- Haemophilus influenza
- Listeria Monocytogenes
- Salmonella typhi
- Neisseria Meningitidis (Meningococcus)
Listeria monocytogenes
A patient has been on Allopurinol 300 mg daily for several months and is well. Which of the following drugs should be avoided and is known to cause dangerous toxicity if taken with allopurinol?
- Tamoxifen
- Aminophylline
- Azathioprine
- Phenytoin
- Carbamazipine
Azathioprine
A patient has a large dose of paracetamol and develops liver dysfunction. Which is the most sensitive marker of liver damage?
- Bilirubin
- Alkaline phosphatase
- AST
- Prothrombin time (clotting)
- GGT
PT
A 53 year old European male presents with a recent history of weight loss and sudden onset of abdominal pain and fever. On examination the abdomen is distended with signs of peritonitis. He undergoes emergency laparotomy and and partial resection of small bowel and associated mesentery.
Over the next few days the following laboratory results become available:
FBC and renal profile normal
LDH 12,000u/ml (NR 50-234)
EBV IgG serology positive, HIV 1 antibody positive
The histopathology description of a mesenteric lymph node: The node is effaced and diffusely infiltrated by large lymphoid cells. Under low poor the node has a starry sky appearance. On immunohistochemistry the large cells are positive for CD20, surface Immunoglobulin, myc and EBER (Ebstein Barr Virus encoded small RNAs) the cells are negative for CD3 and CD30. Ki67 expression is 98%. Karyotype analysis reveals t(8;14)(q24;q32).
What is the most likely diagnosis?
- Gastric Marginal Zone Lymphoma
- Burkitt Lymphoma
- Enteropathy associated T cell lymphoma of the small bowel
- Diffuse Large B cell Lymphoma
- Acute lymphoblastic leukaemia
Burkitt Lymphoma
Superoxide dismutase 1 is a misfolded protein associated with which condition?
- Parkinsons disease
- Motor neurone disease
- Alzheimer’s disease
- Relapsing and remitting multiple sclerosis
- Guillain Barre syndrome
Motor neurone disease
In a test for a disease, which term describes the number of true positives divided by the total number of people that have the disease? (covered in week 0 lecture by Maggie Hancock)
- Specificity
- Negative predictive value
- Sensitivity
- Positive predictive value
- Z-score
Sensitivity
