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Theme 15: Paediatrics (Diseases affecting children and neonates) > 15.11.6.1 Rheumatology in childhood > Flashcards

15.11.6.1 Rheumatology in childhood Flashcards

Describe the historical background of Peads rheumatology. Recap of basic connective tissue system recap of adaptive immunity and autoimmune disease recap of innate immunity and auto-inflammatory disease reflect on South African experiences. highlight common and relevant presentations and conditions in pediatric rheumatology in our local setting.

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Sight Words (Ages 4-6) flashcards UMT for Kids flashcards
1
Q

Rheumatic fever

A

correlation to athritis

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2
Q

What is paeds rheumatic

A
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3
Q

Embryonic development -3 germ layers focus on the mesoderm

A

mesoderm divisions

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4
Q

Cartilage
Tendons
Ligaments

A

Cartilage: tough,flexible,cushions and at the end of bones .
Tendons

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5
Q

Joints and their types

A
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6
Q

Connective tissue: muscles

A
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7
Q

innate immunity

A
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8
Q

adaptive immunity

A

Protects against almost any invader
adapts to antigen to be more specific ,memory

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9
Q

Central and peripheral tolerance

A

central: mechanism of tolerance to self-antigens in the bone marrow and thymus, which eliminates

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10
Q

Auto-immunity

A

Loss of immunological tolerance:
Immune attack on self
auto immune diseases
-

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11
Q

Risk factors for auto immunity

A

-Genetics
- Environment
-Loss of tolerance

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12
Q

Innate immune responses

A

Inflammation
Accumulation and activation of leukocytes
auto-inflammation: result of the disregulation fo the innate system

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13
Q

Auto-inflammatory conditions

A

Systematic juvinile diabetes

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14
Q

Tabulate the differences between autoinflammation and auto- immunity.

A
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15
Q

SA context: challenges facing children with JIA in SA

A

TB and HIV
Malnutrition
Poverty

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16
Q

Juvenile idiopathic arthritis

A

Most common form of chronic childhood arthritis and has 7 subcategories by ILR

17
Q

Oligo(<4)-articular

A

common
Uveitis
Persistent type: >5 joints lating for 6 months

18
Q

Systematic JIA

A

aoutoinflammatoty, the rest=auto immunity

19
Q

Oligoarticular JIA

A

chronic asymptomatic uveitis is a major problem.
ANA + in 85%
leg length discripencies

20
Q

Polyarticular

A

> 5 joints
RF positive<RF neg

21
Q

TMJ Involvement

A
22
Q

Enthesitis related arthritis

A

Usually older children, esp. boys over 6 years
stiffness when they wake up

23
Q

Psoriatic JIA

A

Athritis plus:
psoriasis: hairline,look behind the ears
nail pits
dactylitis
1st or 2nd degree relative

24
Q

Systemic JIA

A

athritis and fever:
-associated with with rash, salmon…

25
Q
A

Theme 15: Paediatrics (Diseases affecting children and neonates) (8 decks)

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