1.5 HA Scheme Intro

Question 1

classic migraine symptoms

Answer 1

aura, unilateral, throbbing, incapacitating, N/V, photophobia, phonophobia, worse with exercise, duration: 4-72 hours, patients just want to lay down in a dark/quiet room

Question 2

4 stages of migraine

Answer 2

1. prodrome (day or 2 before migraine) 2. aura (right before HA) 3. HA 4. postdrome

Question 3

migraine aura

Answer 3

usually lasts 5-60 minutes. 1. can have visual disturbances 2. sensory disturbances (paresthesias) 3. motor (limb weakness) 4. speech (slurred)

Question 4

migraine mechanism

Answer 4

1. Cortical Spreading Depression (CSD) (and subsequent pain) triggered thu CN V and brainstem –> thalamus 2. wave of (CSD) from occiput –>rostral.

Question 5

migraine grey matter vs white matter:

Answer 5

1. if surface CSD (grey matter/neurons); + aura w/depolarization (scotoma).
2. if interior cortex CSD (white matter/axons); - aura

Question 6

migraine triggers

Answer 6

many! Stress
	Hormones (women)
	Skipped meals
	Weather
	Sleep changes
	Perfume
	Foods