140 Must Know Meds

Question 1

Alteplase

Answer 1

Generic Name: alteplase
Trade Name: t-PA

Indication: MI, acute ischemic stroke, occluded central lines

Action: converts plasminogen to plasmin which degrades the fibrin found in clots

Therapeutic Class: thrombolytics

Pharmacologic Class: plasminogen activators

Nursing Considerations:
contraindicated in active bleeding
monitor closely for signs of bleeding (petechiae) (q 15 min X 1hr & q 15- 30 min X 8 hr)
use caution with patient who have had recent surgery
may cause intracranial hemorrhage
monitor for anaphylaxis
use caution with uncontrolled hypertension
assess neuro status during therapy