14. Antiplatelets

Question 1

antiplatelets

Answer 1

used to prevent arterial thrombosis by

COX inhibition
increase plasma adenosine
phosphodiesterace-3 (PDE-3) inhibiton
P2Y12 ADP inhibiton
glycoprotein 2b/3a inhibiton

Question 2

COX inhibitors

Answer 2

cause irreversible inhibition of cyclooxygenase 1 and 2 - enzyme responsible for making thromboxane A2 which causes platelets to aggregate

aspirin only medication in this class

effects last for duration of platelet (7-10 days)

Question 3

P2Y12 inhibitors

Answer 3

prevent platelet activation by inhibiting ADP binding to P2Y12 receptor on platelet - decrease platelet stickiness

monitoring platelet assay tests

irreversible and reversible

clopidogel - irr
prasugrel - irr
ticlopidine - irr
ticagrelor- rev
cangrelor - rev
Cannot stop takinf reversible