14. Analogues and antagonists of estrogen, gestagens, androgens, HRT, hormonal contraception Flashcards
analogues and antagonists of peripheral sex hormones- general
-sex hormones are steroid hormones produced by gonads and the zona reticulularis of the adrenal cortex
-female sex hormones-> estrogen and progestogens
-male sex hormones->androgens
how are the analogues and antagonists of peripheral sex hormones -classified?
estrogens-antiestrogens
gestagens-antigestgagens
androgens-antiandrogens
what are the indications of analogues and antagonists of peripheral sex hormones ?
-hormone replacement therapy
-treatment of gyne problems
-hormone contraception
-treatment of cancer
-treatment of derm problems
estrogens - classification
-natural estrogens
-synthetic estrogens
-estradiol esters
what are the natural estrogens
estradiol
estrone
estriol (has the lowest efficacy of natural estrogens )
what are the synthetic estrogens
-ethinylestradiol
what are the estradiol esters?
-estradiol valerate
-estradiol benzoate
what effect do estrogens have on gonads
-development and maturation
-endometrium proliferation
-increased myometrium contractility
-enhance oviarian follicle maturation
-decreased vaginal pH
what effect do estrogens have on the CNS
they influence sexual behaviour
what effect do estrogens have on metabolism
-favoured effect on metabolism Increased HDL and decreased LDL
-increased cholesterol content in bile
-inteferes with lipid metabolism by increasing serum TAGs
-increases renal resorption of water and sodium -> fluid retention
-
what are additional effects estrogen has ?
-stimulates osteoblast activity
-decreases sebaceous gland in skin
affects synthesis of proteins in the liver -> increase in coag factors and fibrinogen but decreases anti thrombin
indication for estrogen
-substitution therapy (natural estrogen is preferred)
-hormonal contraception (synthetic estrogen is preferred)
