133. Pathology of the penis

Question 1

Hypospadiasis

Answer 1

malformation of the penis, distal urethral orifice on the inferior (ventral) aspect of the penis due to failure of the urethral folds to close

Question 2

Epispadiasis

Answer 2

malformation of the penis, distal urethral orifice on the superior (dorsal) aspect of the penis due to abnormal positioning of the genital tubercle

Question 3

Phymosis

Answer 3

condition in which prepuce cannot be retracted easily over the glans penis.

can be a congenital anomaly or due to scarring of the prepuce due to balanposthitis, which is inflammation of the prepuce due to candida, gardenella, pyogenic bacteria, or smegma.

Question 4

Neoplasms

Answer 4

risk groups: age related (patients over 40 that are not circumcised), poor hygiene, smoking or HPV infection

Question 5

Bowen’s disease

Answer 5

squamous cell carcinoma in situ

morphology: superficial white plaque on the shaft of the penis; dysplastic cells throughout the epidermis with no invasion of the underlying stroma
progression: give rise to invasive SCC in 10% of patients

Question 6

Carcinoma of penis

Answer 6

invasive squamous cell carcinoma
- typical keratinizing scc
- cause: 50% HPV
- morphology: grey, crusted, papular lesion
- position: glans penis or prepuce
- ulcers: infiltration of underlying CT produces
superficial ulceration
- prognosis: after distant spread it is poor (ex: inguinal
lymph nodes)

verrucous carcinoma

- non HPV variant of SCC    - papillary architecture    - locally invasive (doesn't metastasize)