13 - immune mediated disorders

Question 1

(uveodermatologic syndrome)

1. intense immune-mediated response targeting what?
2. signal?
3. cx?
4. skin lesions are cosmetic

Answer 1

1. melanocytes
2. young adult dogs
3. acute uveitis, hypopigmentation of skin on face

Question 2

(Dermatomyositis)

1. inherited disorder seen in what breeds?
2. age of onset?
3. inflammatory response targeting what?

resulting in what?

Answer 2

1. collies and shetland sheepdogs
2. before 1 year
3. hair follicles and muscles of mastication

muscle atrophy and scarring

Question 3

(juvenile cellulitis)

1. what age affected?
2. lesions?
3. distribution?
4. tx?

Answer 3

1. young dogs
2. pustules, crusts, cellulitis

(can get regional lymphadenopathy)

3. head and neck
4. abx for bacterial skin infection

corticosteroids required

Question 4

(erythema multiforme and toxic epidermal necrolysis)

1. unknown mech - thought to be caused by what?
2. lesions?
3. tx?

Answer 4

1. antigen (drug, toxin, vx, etc)
2. vesicular to ulcerative skin lesions
3. avoidance, possible immunosuppressive therapy

Question 5

(sebaceous adenitis)

1. what is it?
2. breeds?
3. Cx?
4. tx?

Answer 5

1. immune mediated destruction of the sebaceous glands
2. poodle, akita, samoyed, vizsla
3. scales and alopecia, 2° bac infections
4. topical treatments to “replace” sebum

Question 6

(plasma cell pododermatitis)

1. soft, painless swelling of footpads in cats