1.2.3 Treatment and management of mood (affective) disorders Flashcards
Drug therapy
Lithium
Malhi et al. (2013) noted Lithium has been used for 50+ years as an effective treatment.
Works well as stablising manic moods, but doesn’t affect depression much.
It possesses anti-suicidal properties that no other drug has achieved.
Drug therapy
Side effects of Lithium
- Drowsiness
- Hand tremors
- Dry mouth, increased thirst/urination
- Nauseau, vomiting, appetite loss
- Stomach pain
- Impotence, loss of interest in sex
- Feeling uneasy
- Changes in skin/hair
Drug therapy
Paliperidone
Joshi et al. (2013) noted Paliperidone was effective in treating acute bipolar disorder in children/adolescents after an 8-week randomised trial where all ppts took the drug.
Drug therapy
Side effects of Paliperidone
Significant weight gain (average 4.1lbs).
Drug therapy
Olanzapine
Katagiri et al. (2013) conducted a study to test the efficacy/safety of using olanzapine for bipolar disorder.
In the drug group, patients showed greater improvement in symptoms across a range of questionnaires, however, they also showed greater weight gain and a rise in cholesterol.
Unipolar - Biological treatments
Tricyclics
A class of medications that are used primarily as anti-depressants.
They were first discovered in the early 1950s and were marketed later in the decade.
Unipolar - Biological treatments
Side effects of tricyclics
- Dry mouth
- Dry nose
- Blurry vision
- Constipation
- Cognitive/memory impairment
- Increased body temperature
Biological treatments
Monoamine oxide inhibitors (MAOIs)
The first class of antidepressants to be developed.
Stopped being used due to concerns about interactions with certain foods and numerous drug interactions.
They elevate levels of norepinephrine, serotonin and dopamine by inhibiting an enzyme called monoamine oxidase.
Biological treatments
Side effects of MAOIs
- Dry mouth
- Hypertension
- Lethal with some foods!
- Nauseau, diarrhoea or constipation
- Headache
- Drowsiness
- Insomnia
- Dizzy/lightheadedness
Biological treatments
Selective serotonin reuptake (SSRIs)
A class of drugs that are** typically used as anti-depressants in the treatment of major depressive disorder and anxiety disorders**.
These are the newest anti-depressants.
Biological treatments
Side effects of SSRIs
Increased suicidal thoughts.
Biological treatments
What did Rucci et al. (2011) find out about the effectiveness of SSRIs on reducing suicidal thoughts?
SSRIs may reduce suicidal thoughts in people with major depression.
Biological treatments
What did Nordenskold et al. (2013) find out about the effectiveness of using ECT with drug therapy alone?
In the group of ppts with drug therapy, 61% relapsed within a year, compared to 32% of patients who had ECT + drug therapy.
Biological treatments
Strengths of drugs
- Alleviates symptoms
- Has saved many lives and helped normal functioning
- More useful for moderate/severe depression
Biological treatments
Criticisms of drugs
- Don’t cure illness
- Side effects
- Cause dependency
- Take time to work
- Less useful for mild depression