12 - Using yeast to understand cell trafficking pathways Flashcards

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1
Q

What are the two membrane trafficking pathways?

A

Secretory/exocytic (biosynthetic) pathway - ER to the golgi to PM/ endosome/lysosome

endocytic pathway (recycling or degradative) - cell surface to endosome to Golgi/ER/lysosome

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2
Q

Are mitochondria part of the secretory pathway?

A

No

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3
Q

Where are proteins modified + Processed?

A

Modified by oligosaccharide addition in the ER
Processed in the golgi

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4
Q

what types of glycosylation occur in proteins?

A

n- and o-

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5
Q

What are the steps of glycosylation?

A

ER lumen:
addition of pre-formed oligosaccharide to an asparagine aa

Addition + processing of oligosaccharides during transit

In golgi:
oligosaccharide group is trimmed
later in golgi - further sugars added + more branches

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