12. Multiple Endocrine Metaplasia Flashcards
Typically speaking, where is the first location someone with MEN 1 develop a tumor?
Parathyroid glands.
Which MEN syndrome is also called Sipple syndrome?
MEN 2A
What is the most common type of pituitary adenoma in MEN 1?
What are the symptoms of this tumor?
Prolactinoma.
Galactorrhea and amenorrhea in women.
Impotence in men.
What are the common tumor locations between MEN 2A and MEN 2B?
Medullary thyroid carcinoma.
Pheochromocytoma.
Which MEN syndrome is also called Wermer syndrome?
MEN 1
Dr. Lopez asked us to associate pheochromocytoma with what clinical finding?
Hypertension.
In which MEN syndrome do we see marfanoid habitus?
MEN 2B
Cutaneous lichen amyloidosis is associated with which of the MEN syndromes?
MEN 2A
What is the most common sign of MEN 2 in general?
Malignant transformation of the parafollicular C cells as a medullary thyroid carcinoma.
What is the main type of pancreatic endocrine tumor in MEN 1?
Gastrinoma.
Where are the tumor locations in MEN 2B?
Medullary thyroid carcinoma.
Pheochromocytoma.
Neuroma (often of the tongue).
What gene is affected in MEN 1?
What protein does this gene produce?
What is the function of that protein?
MEN 1 gene.
Menin.
Menin is a tumor suppressor.
What gene is affected in MEN 2?
What protein does that gene code for?
What is the function of that protein?
RET proto-oncogene.
A receptor tyrosine kinase.
Phosphorylates and activates enzymes critical to cellular development.
What is the common origin for the multiple endocrine neoplasia tumors?
Amine precursor uptaken decarboxylation cells (APUDs).
Where are the locations of tumors in MEN 1?
Parathyroid.
Pituitary.
Pancreatic (endocrine).
