12 - Brain Tumors Flashcards
How common are brain tumors?
- 20,000 brain/spinal cord tumors/yr
- 1.3 % of all cancers
What are the types of primary cancers that commonly lead to a large majority of brain mets?
*** KNOW THIS **
- Melanoma
- Lung
- Breast
- Colon
- Kidney (these like to go to the brain - you see this on the boards)
** KNOW THIS **
Are the large majority of brain cancers primary or mets?
Large majority are METS***
Describe primary brain tumors
- There are cancerous primary brain tumors and non-cancerous
- Cancerous are invasive and aggressive
- While “benign” brain tumors lack those qualities, they can also be life threatening due to limited space in the brain
- Both can lead to bleed, stroke or seizures, etc.
*** Even though it is better to have a benign than a cancerous, both are bad
What are the chances of a primary brain tumors leaving the brain?
They RARELY leave the central nervous system
What are the risks for developing primary brain tumor?
These are rare
- Gene mutations
- MEN 1 (pituitary)
- Neurofibromatosis
- Retinoblastoma (malignant retinal glioma)
Describe environmental contributions to brain cancer?
Vinyl Chloride – used in mfg of chloride (and is present in tobacco smoke). People who work in the plants or live near-by have an increased risk. Pretty accepted risk factor although accounts for small number
Does being married to someone with brain cancer increase your risk?
Environmental
NO
Spouses had no increased risk. First degree relatives had 2-3 times the risk.
Describe the risk of brain cancer associated with smoking
No association of brain cancer to maternal smoking or exposure to smoke as a child
Describe the risk of cancer in patients who have had chicken pox
Patients with Primary Brain Cancer had medical records reviewed. Having a first degree relative with brain cancer increased risk. Having Chicken Pox or Shingles in history DECREASED risk
Describe the risk of brain cancer in cell phone use
- Cell phone use – emit low level radiation.
- Recent studies showing risk
Describe the signs and symptoms of brain tumors in the pituitary
- Behavioral changes
- Sexual issues
- BP chages
- Na changes
KNOW THIS ONE ***
Describe an astrocytoma
- Originates in astrocytes (brain glue)
- Number one type of brain cancer in kids
- This type as an adult can become undifferentiated (along with other cells like spongioblasts) and is called Glioblastoma Multiform which is the most common type in adults.
- Glioblastomas aka glios or GBM
What are the four types of astrocytomas and the WHO grades for each type?
- Plocytic astrocytoms (WHO = I)
- Diffuse astrocytoma (WHO = II)
- Anaplastic astrocytoma (WHO = III)
- Glioblastoma (WHO = IV)
What is the 5 year survival rate for each type of astrocytoma?
- Plocytic astrocytoms (77.4%)
- Diffuse astrocytoma (30.4%)
- Anaplastic astrocytoma (21.9%)
- Glioblastoma (2.4%) ***** (this is the bad kind)