12/29

Question 1

What drug is used to treat serotonin syndrome? What are the symptoms of serotonin syndrome?

Answer 1

Cyproheptadine (a 5-HT2 antagonist)

Symptoms: hyperthermia, myoclonus, CV collapse, flushing, diarrhea and seizures

Question 2

What is amantadine used for? What are the symptoms of amantadine toxicity?

Answer 2

amantadine is an antiviral against influenza A and rubella but also increases dopamine release from intact nerve terminals and so can be used for Parkinson’s disease
Symptoms of amantadine toxicity are ataxia, slurred speech and dizziness

Question 3

Which anti epileptic medication puts patients at the greatest risk of developing vitamin D deficiency leading to osteomalacia?

Answer 3

phenytoin (and to a lesser extent, carbamazepine and phenobarbital)

Question 4

What drugs trigger malignant hyperthermia? What are the symptoms of malignant hyperthermia? How do you treat it?

Answer 4

Inhaled anesthetics combined with succinylcholine
Symtoms: hyperthermia, tachycardia, HTN, acidosis, hyperkalemia and muscle rigidity
treat with dantrolene to relax skeletal muscle and limit heat generated by muscle activity

Question 5

What are the symptoms of amphetamine withdrawal?

Answer 5

stomach cramps, hypersomnolence, suicidal thoughts, nightmares

Question 6

Which anti epileptic drug overdose is marked by severe respiratory depression?

Answer 6

barbiturate overdose

Question 7

What are the benefits of giving midazolam IV push right before surgery?

Answer 7

perioperative amnesia (antegrade amnesia), sedation and anxiety relief

Question 8

What is ketorolac used for?

Answer 8

As a supplement to opioids for pain suppression during surgery

Question 9

Although many newer, safer drugs have replaced long term barbiturate use in many medication conditions, what is long term barbiturate use still appropriate for?

Answer 9

certain epilepsies in pregnant women and children