1.1 Pharmacodynamics

Question 1

Pharmacodynamics

Answer 1

The effect of a drug on the body

Question 2

What are the four types of drug targets?

Answer 2

Enzymes
Carriers
Channels
Receptors

Question 3

Potency

Answer 3

The concentration of a drug required to achieve 50% of the maximum response of that drug at that receptor

Question 4

Efficacy

Answer 4

The maximum effect that can be elicited by a drug

Question 5

Agonist

Answer 5

Keeps a receptor in an active state

Question 6

Antagonist

Answer 6

Inhibits the action of an agonist and has no effect if agonist is absent

Question 7

Partial Agonists

Answer 7

On their own, partial agonists cause a response that is smaller than a full agonist but in the presence of a full agonist will reduce the effect of that full agonist.

Question 8

Reversible Competitive Antagonism

Answer 8

Antagonist binds to same sight as ligand and its association is reversible. Increasing concentration of the agonist restores maximal occupancy of the receptor

Question 9

Irreversible Competitive Antagonism

Answer 9

Antagonist binds to same site as ligand but its associated is irreversible. Increasing concentration of the agonist does not restore maximal occupancy

Question 10

Classes of Agonist

Answer 10

Full Agonist
Partial Agonist
Inverse Agonist

Question 11

Inverse Agonist

Answer 11

Inactivates a constitutively activated receptor

Question 12

Therapeutic Index (TI)

Answer 12

ToxicDose50/EffectiveDose50.

Large TI = Wide therapeutic window

Question 13

Hysteresis Loops

Answer 13

Delayed onset of action

Occurs when drug is distributed slowly to site of action

Question 14

Tachyphylaxis

Answer 14

Occurs when acute tolerance to the drug takes place