11-IGF and growth axis Flashcards
1
Q
What does GH regulate
A
Cell survival
Hypertrophy
Differentiation
Metabolism
2
Q
Which organ releases IGF-1
A
Liver
3
Q
Where are GH-V and GH-N expressed
A
GH-V in placenta
GH-N Pituitary gland
4
Q
What are the zones of a growth plate
A
Metaphyseal bone
Invasion zone
Hypertrophic zone
Maturation zone
Proliferative zone
Reserve zone
Epiphyseal bone
5
Q
Enzyme-coupled receptors
A
GH receptor has an enzyme attached, activated through dimerisation (homodimer)
IGF has an active catalytic domain that is activated during dimerisation
Initiates MAP kinase pathway and PI-3 pathways
