1.1 Haematopoiesis Flashcards
What is haematopoiesis?
Formation of blood cells
What is erythropoiesis?
Formation of red blood cells
What is myelopoiesis?
Formation of granuolcytes (neutrophils, basophils, eosinophils) and monocytes
What is thrombopoiesis?
Formation of platelets
What is lymphopoiesis?
Formation of lymphocytes including T and B cells
What are the features of neutrophils?
Bilobular nucleus, granules
Antibacterial phagocytes - cause inflammatory response and phagocytosis
What are the features of basophils?
Lots of granules containing histamine/prostaglandins
Release toxic mediators to deal with parasites and conatins inflammatory mediators
What are the features of lymphocytes?
Round nucleus, no granules
Detect infection, produce cytokines, destroy virus, produce anibodies
What are the features of eosinophils?
Bilobula nucleus
Allergic reactions
Release toxic mediators and role in inflammation
What are band neutrophils?
Immature neutrophils released by bone marrow
What are the sites for haematopoiesis?
Foetus - yolk sac then liver/spleen
Infant - all BM
Adult - Flat bons, Spleen (RBC reservoir), Some residual stem cells in BM
What are the features of the bone marrow microenvironment?
Stromal cells - produce soluble factors
ECM - cell adhesion and soluble factors
How are red blood cells degraded?
After 120 days they travel to the spleen where they are degraded by macrophages.
What is the order or rbc development?
Rubriblast
Prorubricyte
Rubricyte
Metarubricyte
Reticulocyte
Erythrocyte
What is the difference between monocytes and macrophages?
Monocytes are in the blood whereas macrophages are in the tissues.
