1.1 - Energy systems Flashcards
Where does the energy we use for muscle contractions come from?
Adenosine triphosphate (ATP)
What does ATP consist of?
One molecule of adenosine and three phosphates.
How is the energy that is stored in ATP released?
By breaking down the bonds that hold this compound together.
What is adenosine triphosphate?
The only usable form of energy in the body.
What breaks down ATP?
An enzyme called ATPase
What is ATPase?
The enzyme that is used to break down ATP.
What does ATPase break down ATP into?
Adenosine diphosphate (ADP) and an inorganic phosphate (Pi).
How can we resynthesise ATP?
From three different types of chemical reaction fuelled by either food or a chemical called phosphocreatine which is found in the muscles.
What are the 3 energy systems?
The aerobic system, the ATP-PC system, the anaerobic glycolytic system (lactic acid system).
When are the 3 energy systems used?
ATP-PC system = <10s
Lactic acid system = 10s-3mins (depending on intensity).
Aerobic system = >3mins
When is the aerobic system used?
When exercise intensity is low and oxygen supply is high.
How much energy can be produced by the complete oxidation of glucose in the aerobic system?
36-38ATP.
How many stages are there to the aerobic system?
3
What are the 3 stages of the aerobic system?
- Glycolysis.
- Krebs cycle.
- Electron transport chain.
What is glycolysis?
A process in which glucose is converted to pyruvate to produce energy.
Where does glycolysis take place?
In the sarcoplasm of the muscle cell.
Explain the first stage of the aerobic system
Glycolysis:
- Anaerobic so takes place in the sarcoplasm of the muscle cell.
- It is the breakdown of glucose to pyruvic acid.
- For every molecule of glucose undergoing glycolysis, a net of two molecules of ATP is formed.
- Phosphofructokinase is added to convert the glycogen to glucose.
- If there is no oxygen present, then the pyruvic acid is turned into lactic acid.
- Pyruvic acid is then oxidised into two acetyl groups and is then carried into Krebs cycle by coenzyme A.
What is the first stage of the aerobic system?
Glycolysis.
What is the second stage of the aerobic system?
Krebs cycle.
What is the third stage of the aerobic system?
Electron transport chain.
What is the sarcoplasm?
The fluid that surrounds the nucleus of a muscle fibre and is the site where anaerobic respiration takes place.
What is Krebs cycle?
A series of cyclical chemical reactions that take place using oxygen in the matrix of the mitochondrion.
Explain the second stage of the aerobic system
Krebs cycle:
- The two acetyl groups diffuse into the matrix of the mitochondria and a complex cycle of reactions occurs.
- The acetyl groups combine with oxaloacetic acid, forming citric acid which releases 2 ATP.
- Hydrogen is removed from the citric acid and the rearranged form of citric acid undergoes ‘oxidative decarboxylation’ which means carbon and hydrogen are given off.
- The carbon forms carbon dioxide which is breathed out.
- The hydrogen is taken to the electron transport chain.
Beta oxidation can also provide fuel for the Krebs cycle.
Explain the third stage of the aerobic system
The electron transport chain:
- Hydrogen is carried to the electron transport chain by hydrogen carriers.
- This occurs in the cristae of the mitochondria.
- The hydrogen splits into hydrogen ions and electrons and they are charged with potential energy.
- The hydrogen ions are oxidised to form water (so oxygen is required).
- The electrons provide the energy to re-synthesise ATP.
- This process forms and releases 34 ATP.
What are other energy sources that are used aerobically?
Fats (fatty acids) and proteins (amino acids) can be broken down under aerobic conditions to provide energy for us to exercise. These can both enter the Krebs cycle and eventually the electron transport chain to produce ATP.
What can also enter the Krebs cycle to help produce ATP?
Fatty acids and amino acids that are broken down.
Also stored fat that is converted into acetyl coenzyme A by beta oxidation.
Explain what Beta oxidation is
Stored fat is broken down into glycerol and free fatty acids for transportation by the blood. The fatty acids can then undergo beta oxidation where they are converted into acetyl coenzyme A, which is the entry molecule for the Krebs cycle. From this point on, fat metabolism follows the same path as glycogen metabolism and more ATP can be produced from fatty acids than glucose so they become the predominant energy source in low intensity, long duration exercise.
What are the advantages of the aerobic system to provide energy?
- More ATP can be produced; 36-38 ATP.
- There are no fatiguing by-products (carbon dioxide and water only).
- Lots of glycogen and triglyceride stores so exercise can last for a long time.
What are the disadvantages of the aerobic system to provide energy?
- It is a complicated system so can’t be used straight away. It takes a while for enough oxygen to become available to meet the demands of the activity and ensure glycogen and fatty acids are completely broken down.
- Fatty acid transportation to muscles is low and also requires 15% more oxygen to be broken down than glycogen.
What is the electron tranpsport chain?
Involves a series of chemical reactions in the cristae of the mitochondria where hydrogen is oxidised to water and 34 ATP are produced.
What is phosphocreatine (PC)?
An energy-rich phosphate compound found in the sarcoplasm of the muscles and can be broken down quickly and easily to release energy to re-synthesise ATP.
What is the ATP-PC system?
An energy system using phosphocreatine (PC) as its fuel.
How does the ATP-PC system work to provide energy?
- It is an anaerobic process and re-synthesises ATP when the enzyme creatine kinase detects high levels of ADP.
- It breaks down the phosphocreatine in the muscles to phosphate and creatine, releasing energy.
Phosphocreatine (PC) –> Phosphate (Pi) + Creatine (C) + Energy.
- This energy is then used to convert ADP into ATP in a coupled reaction.
- For every molecule of PC broken down, there is enough energy released to create one molecule of ATP.
Is the ATP-PC system aerobic or anaerobic?
Anaerobic.
Write the equation for the production of energy in the ATP-PC system
Phosphocreatine (PC) –> Phosphate (Pi) + Creatine (C) + Energy.
What are the advantages of the ATP-PC system?
- ATP can be re-synthesised rapidly using the ATP-PC system.
- Phosphocreatine stores can be re-synthesised quickly - [30 s = 50% replenishment and 3 mins = 100%].
- There are no fatiguing by-products.
- It is possible to extend the time the ATP-PC system can be utilised through the use of creatine supplementation.
What are the disadvantages of the ATP-PC system?
- There is only a limited supply of phosphocreatine in the muscle cell, i.e. it can only last for 10s (5-8s).
- Only one molecule of ATP can be re-synthesised for every mole of PC.
- PC re-synthesis can only take place in the presence of oxygen (i.e. when the intensity of the exercise is reduced).
What does anaerobic mean?
A reaction that can occur without the presence of oxygen.
What is a coupled reaction?
When energy required by one process is supplied by another process.
What is the short-term lactate anaerobic system (lactic acid system)?
Produces high powered energy for high intensity effort in events such as the 400m.
What is the short-term lactate anaerobic system (lactic acid system) also called?
The anaerobic glycolytic system.
How long the short-term lactate anaerobic system (lactic acid system) lasts depends on what?
The fitness of the individual and how high the exercise intensity is.
How does the short-term lactate anaerobic system (lactic acid system) work to provide energy?
- When the PC stores are low, the enzyme glycogen phosphorylase is activated to break down the glycogen into glucose, which is then further broken down to pyruvic acid by the enzyme phosphofructokinase..
- This process called anaerobic glycolysis takes place in the sarcoplasm of the muscle cell where oxygen isn’t available.
- Because it is an anaerobic process the pyruvic acid is then further broken down into lactic acid by the enzyme lactate dehydrogenase (LDH).
- During anaerobic glycolysis, energy is released to allow ATP re-synthesis.
- The net result is 2 molecules of ATP produced for one molecule of glucose broken down. (There are actually 4 moles of ATP produced but 2 are used to provide energy for glycolysis itself.)
Where does anaerobic glycolysis take place?
In the sarcoplasm of the muscle cell where oxygen isn’t available.
How much energy is produced by the ATP-PC system?
One molecule of ATP can be re-synthesised for every mole of PC.
How much energy is produced by the short-term lactate anaerobic system (lactic acid system)?
2 molecules of ATP produced for one molecule of glucose broken down. (There are actually 4 moles of ATP produced but 2 are used to provide energy for glycolysis itself.)
What are the advantages of the anaerobic glycolytic system?
- ATP can be re-synthesised quite quickly due to very few chemical reactions and lasts for longer than the ATP-PC system.
- In the presence of oxygen, lactic acid can be converted back into liver glycogen or used as a fuel through oxidation into carbon dioxide and water.
- It can be used for a sprint finish (i.e. to produce an extra burst of energy).
What are the disadvantages of the anaerobic glycolytic system?
- Lactic acid as the by-product! The accumulation of acid in the body denatures enzymes and prevents them increasing the rate at which chemical reactions take place.
- Only a small amount of energy can be released from glycogen under anaerobic conditions (5% as opposed to 95% under aerobic conditions).
What is the energy continuum?
A term which describes the type of respiration used by physical activities. Whether it is aerobic or anaerobic respiration depends on the intensity and duration of the exercise.
What is the ATP-PC/anaerobic glycolytic threshold?
The point at which the ATP-PC energy system is exhausted and the anaerobic glycolytic system takes over.
What is energy supplied by when the duration of the performance is less than 10s?
ATP-PC
What is energy supplied by when the duration of the performance is 8-90s?
ATP-PC and anaerobic glycolytic.
What is energy supplied by when the duration of the performance is 90s-3mins?
Anaerobic glycolytic and aerobic.
What is energy supplied by when the duration of the performance is 3+mins?
Aerobic.
What are some examples of activities that have their energy supplied by the ATP-PC system and that last less than 10s?
100m, long jump, etc.
What are some examples of activities that have their energy supplied by the ATP-PC system and the anaerobic glycolytic system and that last 8-90s?
200m, 400m, gymnastic floor routine, etc.
What are some examples of activities that have their energy supplied by the anaerobic glycolytic system and aerobic system and that last 90s-3mins?
1500m, a round of boxing, etc.
What are some examples of activities that have their energy supplied by the aerobic system and that last 3+mins?
Marathon, cross country skiing, etc.
What type of exercise are slow twitch muscle fibres used for?
Low to medium intensity.
What do slow twitch muscle fibres use as their main method of receiving fuel?
Aerobic respiration.
What type of exercise are fast twitch muscle fibres used for?
High intensity.
What do fast twitch muscle fibres use as their main method of receiving fuel?
Anaerobic respiration.
Which type of respiration is the quickest?
Anaerobic.
Summarise ATP generation in slow twitch (type 1) muscle fibres
- The main pathway for ATP production is in the aerobic system.
- It produces the maximum amount of ATP available from each glucose molecule (up to 36 ATP).
- Production is slow but these fibres are more endurance based so less likely to fatigue.
Summarise ATP generation in fast twitch (type 2x) muscle fibres
- The main pathway for ATP production is via the lactate anaerobic energy system (during glycolysis).
- ATP production in the absence of oxygen is not efficient as only 2 ATP produced per glucose molecule.
- Production of ATP this way is fast but cannot last for long as these fibres have least resistance to muscle fatigue.
Why is the aerobic system the preferred energy system at low intensity/long duration exercise?
Because the demand for oxygen can be met and glucose can be broken down much more efficiently when oxygen is present.
When are fats used in energy production?
At low intensity, but as intensity increases, their usage becomes limited because they require more oxygen than glucose in their breakdown. As soon as oxygen supplies become limited, fat use for energy drops.
What is oxygen consumption?
The amount of oxygen we use to produce ATP.
What is VO2 max?
The maximum volume of oxygen that can be taken up by the muscles per minute.
What is sub-maximal oxygen deficit?
When there is not enough oxygen available at the start of exercise to provide all the energy (ATP) aerobically.
At what rate do we consume oxygen at rest?
Approx 0.3 to 0.4 litres per min.