11 Basic Molecular Pathology

Question 1

What are the Lung molecular markers

Answer 1

EGFR (epidermal growth factor receptor)
ALK
ROS 1
KRAS
MET
RET
Her2

Question 2

Describe how EGFR acts as a lung molecular markers

Answer 2

Transmembrane RTK

Mutation: deletion in exon 19 of Ch7
-Mutation leads to activation of the TK signalling pathway
-Results in cell differentiation, proliferation

Question 3

Give an example of Anti EGFR TKI drugs

Answer 3

Gefitinib

Question 4

Describe how ALK acts a lung molecular marker

Answer 4

Function: Fusion of genes
-Activation of downstream signals and cell proliferation and survival

Question 5

In what pop. is ALK commonly seen

Answer 5

Young, non-smokers

Question 6

Drugs against ALK

Answer 6

ATP kinase inhibitors
E.g.) Crizotinib