11/7

Question 1

If Pelphrey gives us Ka in an equation you know the drug is an

Answer 1

acidic drug

Question 2

If Pelphrey gives us a Kb in an equation you know the drug is a

Answer 2

basic drug

Question 3

With a base, initially solve for ___ then subtract that from ___

Answer 3

pOH, 14

Question 4

Each buffer has a limit to the amount of acid/base that can be added before the buffer loses its ability to resist change. This is called the ______

Answer 4

buffer capacity

Question 5

Buffers are solutions that contain a….

Answer 5

weak acid and its conjugate base or a weak base and its conjugate acid.

Question 6

What are the three main buffer systems?

Answer 6

bicarbonate (blood buffering system), phosphate, and protein buffer systems

Question 7

Blood pH is controlled through pH regulation which is a function of the buffer systems of the body in combination with the _____ and ____ systems.

Answer 7

respiratory, renal

Question 8

When CO2 is dissolved in water it creates

Answer 8

carbonic acid

Question 9

The renal system removes ____ via the kidneys

Answer 9

hydrogen ions

Question 10

LeChatelier’s principle

Answer 10

when a system at equilibrium is disturbed, the system will adjust to reestablish that equilibrium

Adjustment is typically in the opposite direction of what we did

Question 11

If you add a reactant equilibrium will shift towards..

Answer 11

the products

Question 12

How do we determine to overall pH?

Answer 12

Henderson-Hasselbach equation

Question 13

How does the Henderson-Hasselbach equation work?

Answer 13

Allows us to take the pKA of our weak acid/base as well as relative amounts of conjugate pairs to determine pH

Question 14

Bases can be neutral or negative but will never be

Answer 14

+

Question 15

Acids can be plus or neutral but will never be

Answer 15

negative

Question 16

Drug charge is controlled by both the ___ and ___

Answer 16

pH of the solution and the pKa of the drug

Question 17

In the Henderson Hasselbalch equation, is [A-] ionized or unionized

Answer 17

ionized

Question 18

In the Henderson Hasselbalch equation, is [HA] ionized or unionized

Answer 18

unionized

Question 19

With drug ionization, you will always be given the pKA whether the drug is an __ or a __

Answer 19

acid or base

Question 20

if pH < pKa

Answer 20

protonated form, weak base will be charged, weak acid will be uncharged

Question 21

if pH > pKa

Answer 21

favors unprotonated form, weak base will be uncharged, weak acid will be charged