109: U5: Acute Resp Disorders Flashcards
Influenza Definition
Highly contagious, acute viral respiratory infection. Season for flu: October - April.
Influenza Etiology
Viral
Influenza Pathophys
3 groups of viruses - A, B, & C. Viruses have the ability to change over time.
Influenza S/S
Abrupt onset.
Headache, muscle ache, fever, chills, fatigue,, weakness, anorexia (lasts about a week).
Sore throat, cough, rhinorrhea
Dyspnea, crackles (starting to get a pulm complication)
Malaise 1-2 weeks after
Cough may persist for weeks.
Influenza Tx
Symptomatic treatment: analgesics, antipyretics, antihistamines, cough syrup, fluids, rest.
Antivirals: amantidine, tamiflu (only if taken within 24 hours of onset of s/s)
Vaccinations. Flumist (live, weakened virus) do not give to immunocompromised patients.
Pneumonia Definition
An inflammatory process of the lungs.
7th leading cause of death in the U.S.
Pneumonia Etiology
Bacterial, viral, mycoplasma, fungi, parasites, chemicals.
Decreased defense mechanisms - decreased consciousness, intubation, smoking, URI, malnutrition.
Aspiration, inhalation, hematogenous spread.
Pneumonia Pathophys
Community acquired (come in with or develop within 2 days of hospital stay). Hospital acquired (insurance will not pay). 4 characteristic stages.
Pneumonia S/S (Typical)
Fever
Chills, cough, sputum (rust colored)
Hypoxemia, tachypnea, tachycardia.
Pleuritic pain, myalgia, headache.
Crackles, wheezing, fatigue, dyspnea, diminished breath sounds, SOB.
Increased fremitus (feel vibration), dullness to percussion (instead of resonance).
Pneumonia S/S (Atypical)
Mycoplasma, Legionella - gradual onset, dry cough, headache, myalgia, fatigue, N, V, D, crackles.
Viral - chills, fever, dry cough
Pneumonia Tx
Viral - Supportive treatment
Antibiotics
Analgesics for aches/pains
Supportive tx: O2 if hypoxic, HOB up. Fluids (up to 3L/day).
Positioning (if on side, good lung down). HOB up.
Vaccinations
Pneumonia Goal
Start abx within 4 hours in hospital.
Usually hospitalized for decreased POX, age,, ability to care for self, dehydration.
Pneumonia Isolation
Droplet
TB Definition
An infectious disease caused by mycobacterium tuberculosis.
TB Etiology
Gram positive bacilli.
M. Tuberculosis - transmitted by aerosolization.
Repeated close contact, HIV, lower socio-economic group, IVDA, or ETOH abusers, crowded living conditions, long term care, prisoners all at high risk.
TB Latent Infection
No symptoms, pt does not feel sick and cannot spread to others.
Usually a positive skin TB or Quantiferon Gold test. Normal CXR and sputum.
Bacteria alive but inactive and can become active later.
Can develop active TB disease if they don’t receive treatment (3-6 mo of INH).
TB Active Infection
Symptoms may include: Bad cough (lasting 3 weeks or longer) Pain in the chest Coughing up blood/sputum Weakness/fatigue Weight loss, no appetite Chills, fever, NIGHT SWEATS May spread TB to others. Positive TB skin test/Quanteferon gold. Abnormal CXR, positive AFB test.
TB Miliary Infection
Active TB may spread to other parts of the body - kidney, brain, spine. Not infectious here (less likely to spread to others as it is not in the lungs).
TB Isolation
Airborne
TB Drugs
Use a combination of 4 drugs for active TB. Isonazid (INH) Rifampin (RIF) Ethambutol (EMB) Amikacin Pyrazinamide (PZA) Streptomycin (SM) Rifapentine Rifater
INH SEs
Peripheral neuritis (give vit b6) Liver toxicity Optic neuritis B6 neuritis skin rash, joint pain, fever
INH NIs
Give Vitamin B6 Monitor AST/ALT (LFT's). No ETOH, APAP. Monitor BUN/Creat Look up drugs (many interactions) Avoid antacids: affects the absorption of drugs. Wear a med-alert bracelet. Take with meals.
Rifampin SEs
Low incidence of SEs Orange urine/body fluids Drug interactions Hepatitis fever, GI disturbance, periph neuropathy, hypersensitivity.
Rifampin NIs
Same as INH.
Use additional birth control
Safe in pregnancy
Ethambutol SEs
SEs are uncommon.
Peripheral neuritis
Optic neuritis: red/green color discrimination
skin rash, GI disturbance
Ethambutol NIs
Give vitamin B6
Baseline vision/color discrimination test (and repeat every 2-3 months.
Safe in pregnancy
Amikacin SEs
Renal and Ototoxicity