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Pharma > 1.04 Anti Arrythmic Drugs > Flashcards

1.04 Anti Arrythmic Drugs Flashcards

Learn about Heart Physiology and Anti Arrythmic Drugs

1
Q

Wave in ECG that represents Atrial Depolarization

A

P WAVE

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2
Q

Wave in ECG that represents ventricular depolaraztion

A

QRS wave

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3
Q

ECG wave that represents Ventricular Repolarization

A

T WAVE

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4
Q

Part of ECG diagram that represents Conduction time from Atrium to Ventricle

A

PR interval

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5
Q

Part of ECG diagram that represents conduction time for ventricular cell action.

A

QRS

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6
Q

Represents duration of ventricular action potential

A

QT interval

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7
Q

STEPS IN SA AND AV NODE DEPOLARIZATION

A

Phase 0 - Phase 3-Phase 4

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8
Q

SA and AV Node is Mediated by what?

A

CALCIUM

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9
Q

Phase 0 is mediated by what?

A

Ca channel

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10
Q

Phase 3 is mediated by what?

A

K channel

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11
Q

Phase 4 is mediated by what?

A

Funny sodium channel

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12
Q

What ion mediates the depolarization of the ventricles,atria and the Purkinje System?

A

Na

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13
Q

Phase 0 in ventricular muscles is mediated by what ion?

A

Na Channel

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14
Q

Phase 2 in ventricular muscles is mediated by what ion?

A

Calcium

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15
Q

Phase 3 and Phase 4 in ventricular muscles is mediated by what ion?

A

Potassium

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16
Q

The 3 conditions that must coexist for Reentry to occur?

A
  1. There must be an obstacle
  2. There must be a unidirectional block at some point in the circuit
  3. Conduction time must exceed the effective refractory period.
17
Q

Name an example of a disease in which Re-Entry phenomenon occurs

A

Wolf Parkinson White Syndrome

supraventricular tachycardia

18
Q

Factors that exacerbate of precipitate arrythmia

A 
Ischemia
Hypoxia
Acidosis or alkalosis
Catecholamine Exposure
Autonomic Influence
Drug Toxicities
Presence of scarred tissues
Overstretching of cardiac fibers
19
Q

> 100 beats per min

A

Sinus tachycardia

20
Q

<60 beats per min

A

Sinus bradycardia

21
Q

Paroxysmal Tachycardia occuring in the atrium or the AV node

A

SVT

22
Q

decreased intesity of QRS complex

A

Atrial Flutter

23
Q

Unreadable P waves

A

Atrial Fibrillation

24
Q

Aim of Therapy of Antiarrythmic Drugs

A
  1. Reduce ectopic pacemaker activity

2. Modify conduction velocity

25
Q

How do anti arrythmic drugs reduce ectopic pacemaker activity?

A

By blocking Na or Ca channels

26
Q

How do anti arrythmic drugs modify conduction velocity?

A

By reduction of readily available unblocked channels or through the prolongation of recovery time of the channels still able to reach the rested and available state, which increases the ERP.

27
Q

AntiArrythmic Agents (4 types)

A

Sodium Blockers
Beta Blockers
Potassium Blockers
Calcium Blockers

28
Q

Class 1 Of antiarrythmic drugs

A

Sodium Channel Blockers

29
Q

Class 1A of Antiarrythmic drugs

A

Disopyramide
Quinidine
Procainamide

Pharma (1 decks)

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