10 Vascular occlusions and myopathies Flashcards
Risk factors for hypertensive retinopathy:
> 40 yo
Stroke (related to cotton wool spots)
Heart failure
Brain damage
Renal failure
Ocular diseases related to hypertension
Retinal vein/artery occlusion
Ischaemic optic neuropathy
Progression of diabetic retinopathy
Glaucoma
AMD
Pathophysiology of ocular hypertension:
Rising BP > vasospasm > retinal artery narrowing > hyperplasia (copper wiring) > venule compression (nipping)
BRB breakdown > haemorrhaging / lipid (hard) exudates > nerve ischemia (cotton wool spot) > disc oedema
Stages of hypertensive retinopathy:
Mild: artery narrowing/coppering/nipping
Moderate: flame/blot haemorrhage, lipid exudate, cotton wool spot, microaneurysms
Severe: Disc oedema (papilloedema)
Hypertensive retinopathy management:
Mild: routine care
Moderate: Daily BP monitor
Severe: antihypertensive care
Treated via angiotension-converting enzyme (ACE) inhibitors
Retinal vein occlusion presentation
Dilated / tortuous veins with haemorrhages, cotton wool spots, macula/disk oedema.
Either central (whole retina affected), or branch (sectioned away from disc)
Retinal vein occlusion risks
Hypertension (5x likely)
Diabetes
Stroke
Smoking
Retinal vein occlusion complications:
Neovascularisation
Macula oedema
Retinal emboli presentation:
Small discoloured lesions in lumen of arterioles
Cholesterol crystals > reflective emboli (white)
Calcium/fibrin > non-reflective emboli
Retinal emboli epidemiology:
1.5% incidence >40yo
Asymptomatic emboli > 90% self resolved in 5 years
Retinal emboli risk factors
Hypertension
Diabetes
Smoking
Retinal emboli causes and treatment
Plaque breakoff from large artery (carotid)
Treated via anticoagulants
Central retinal artery occlusion clinical presentation:
Sudden painless unilateral loss of vision
Whitening of retina with red macula (cherry red spot)
Branch retinal artery occlusion clinical presentation
Visual field defect
Present with emboli
CRAO treatment:
Embolus dislodgment via eye massage, IOP decrease, bag hyperventilation (CO2 induced vasodilation)