10 Respiratory pathology Non-neoplastic Flashcards
Respiratory pathology Non-neoplastic”
Overview
Anatomy and physiology Infection Obstructive/restrictive disorders Vascular Expansion Respiratory failure Summary
The respiratory system
Upper airways: nose, accessory air sinuses, nasopharynx, larynx
Lower airways: trachea, bronchi, bronchioles, terminal bronchioles, alveoli
Pleura
General overview
Infections:
Uri/sinusitis
Flu
Pneumonia
Obstructive disorders:
COPD – bronchitis/emphysema
Asthma
Bronchiectasis
Miscellaneous:
Respiratory failure
Restrictive:
Chest wall abnormalities
Connective tissue disorders
pneumoconioses
Vascular disorders:
Pulmonary oedema
Pulmonary embolism
Expansion disorders:
Atelectasis
pneumothorax
Infection upper airways
Definition: acute inflammatory process that affects mucous membranes of the respiratory tract
Includes: rhinitis, laryngitis, tonsilitis sinusitis
Symptoms: malaise, headache, sore throat, discharge
Aetiology
Commonly viral
Can get secondary bacterial infection
Lower airways: infectionPNEUMONIA
Definition: Inflammation of the lung parenchyma
- Consolidation of the affected part
- Exudate with inflammatory cells and fibrin in the alveolar air spaces
Causes: infectious agents inhalation of chemicals chest wall trauma Categories Setting: Community acquired Hospital acquired Aspiration pneumonia Chronic pneumonia Necrotizing pneumonia and lung abscesses Pneumonia in the immunocompromised host
Pneumonia
Clinical features/course
Fever, rigours, SOB, pleuritic chest pain, purulent sputum, cough
Morphology:
Lobar
Multifocal/lobular (bronchopneumonia)
Interstitial (focal diffuse)
Community acquired pneumonia
Relatively common, especially in elderly population
Strep. pnuemoniae most common organism
Haemophilus influenzae
Staph aureus- complicates viral infection and in IVDU
Lobar or bronchopneumonia
Hospital acquired pneumonia
Aka nosocomial pneumonia
Any pneumonia contracted by patient at least 48-72hrs after admission
Usually bacterial- gram negative bacilli and Staph aureus
Severe and can be fatal- most common cause of death in ITU
Fever
Increased white cell count
Cough with purulent sputum
Chest X-ray changes
Aspiration pneumonia
Develops after inhalation of foreign material.
Elderly, Strokes, Dementia, Anaesthetic
Usually right middle and right lower lobe
Oral flora +/- other bacteria
Obstructive vs restrictive
Diffuse pulmonary disease divided into:
Obstructive disease
Characterised by partial or complete obstruction at any level from the trachea to respiratory bronchioles
PFT: limitation of maximal airflow rate during forced expiration FEV1
Restrictive disease
Characterised by reduced expansion with decreased total lung capacity,
FVC is reduced: amount of air that can be blown out after maximal inspiration
Obstructive
Asthma Reversible airways obstruction common COPD Emphysema Chronic bronchitis Bronchiectasis chronic infection leading to destruction and dilatation of the airways
COPD - Emphysema
Irreversible enlargement of the airspaces distal to the terminal bronchiole - destruction of their walls without obvious fibrosis
Types: centriacinar / panacinar / paraseptal / irregular
Pathogenesis:
mild chronic inflammation throughout the airways
protease – antiprotease imbalance hypothesis
+ imbalance of oxidants and antioxidants
role of smoking and genetics
Emphysema
Morphology: voluminous lungs
large alveoli, large apical bullae or blebs
Clinical course - symptoms:
dyspnoea, cough, wheezing, weight loss
expiratory airflow limitation – “pink pufferrs”
death due to cor pulmonale,
congestive heart failure, pneumothorax
COPD – chronic bronchitis
persistent cough with sputum production
for at least 3 months in at least 2 consecutive years
without any other identifiable cause
Chronic bronchitis cont..
long-standing irritation by inhaled substances (e.g tobacco smoke, dust from grain, cotton, silica)
hypertrophy of submucosal glands in trachea and bronchi, increase in goblet cells
mucus hypersecretion + alterations in the small airways chronic airway obstruction
