10. Heme/Onc Flashcards
1
Q
t(9;22) translocation
associated disorder?
A
(Philadelphia chromosome)
bcr-abl hybrid -> Chronic myelogenous leukemia (CML)
2
Q
t(8;14) translocation
what disorder?
A
Burkitt lymphoma (c-myc activation)
3
Q
t(11;14) translocation
what disorder?
A
Mantle cell lymphoma (cyclin D1 activation)
4
Q
t(14;18)
what disorder?
A
Follicular lymphomas (bcl-2 activation)
5
Q
t(15;17)
what disorder?
A
M3 type of AML
(responds to all-trans retinoic acid - ATRA)