10. Amines

Question 1

what is the classification of amines based on

Answer 1

how many C are directly bonded to N

Question 2

what are the 2 things taht the lone pair e- on the N can act as

Answer 2

base or nucleophile

Question 3

what happens to the basicity of amine if you increase the pka for conjugate acid

Answer 3

increase basicity of amine

Question 4

is the aromatic amine stronger or weaker than the alkyl amine and why

Answer 4

weaker

due to delocalisation of lone e- of N onto ring

Question 5

in aromatic amines what do e- withdrawing substituent on the ring do to the basicity

Answer 5

decreases basicity

Question 6

in aromatic amines what do e- donating substituent on the ring do to the basicity

Answer 6

increases basicity

Question 7

what reagents and reactants are needed when substitution of alkyl halides is used to produce straight chain amines

Answer 7

+NH3

or

+ RNH2

or

+R2NH

Question 8

what reagents and reactants are needed when reduction of nitrile/imine/oxime is used to produce amines

Answer 8

1. LiAlH4
2. H3O+

classification of amide produces same classification of amine

Question 9

what reagents and reactants are needed when substitution of alkyl halides is used to produce aromatic chain amines

Answer 9

1. Fe/H3O+
2. OH-

Question 10

what reagents and reactants are needed when amines react to form primary amides

Answer 10

nucleophile with alkyl and acyl halide

primary or secondary amine + RCOCl

Question 11

can tertiary amines react to form primary amides

Answer 11

no

Question 12

what reagents and reactants are needed when amines react to form diazonium ions

Answer 12

aromatic amine

NaNO2/H2SO4 followed by HONO at 0-5 degrees

Question 13

what is formed when a primary or secondary amine reacts with + RCOCl

Answer 13

primary amides

Question 14

what is formed when an aromatic amine reacts with NaNO2/H2SO4 followed by HONO at 0-5 degrees

Answer 14

diazonium ion