10. Abdominal Pain in Pediatrics Flashcards
Describe: Visceral (splanchnic) pain (4)
- due to noxious stimuli (usually stretch) stimulating receptors of the visceral peritoneum, mesentery, or the muscle or mucosa of hollow organs.
- The associated afferent autonomic nerves have few nerve endings, innervate targets in a bilaterally symmetric fashion, are unmyelinated, and enter spinal cord at multiple levels.
- Thus, visceral pain is dull, poorly localized, and associated with the midline.
- Pain generally sensed in areas corresponding to embryonic origin of affected structure:
- Foregut (esophagus to duodenum at major duodenal papilla, liver, gallblad- der, pancreas)—epigastric
- Midgut (distal 2nd part of duodenum to proximal two-third of transverse colon)—periumbilical
- Hindgut (distal one-third of transverse colon to rectum)—suprapubic/ hypogastric
Describe: Parietal (somatic) pain (3)
- due to noxious stimuli (stretch, inflammation/irritation, tearing) stimulating receptors of the parietal peritoneum, skin, or skeletal muscle.
- Associated somatic afferent nerves are numerous, myelinated, and transmit to a specific dorsal root ganglion.
- Thus, somatic pain is relatively more intense and localized, on the same side and dermatomal region as origin of pain.
Describe: Referred pain (2)
- due to convergence/shared projections of somatic and/or visceral pain pathways in the CNS.
- For example, pneumonia may present as abdo pain due to parietal pleural pain referred to abdo wall.
Name causal conditions of acute abdominal pain in pediatrics: Upper/Epigastric (6)
- Hepatobiliary/pancreatic: acute hepatitis, cholecystitis, cholelithiasis, cholangitis,* acute pancreatitis
- Esophagus: foreign body ingestion, esophagitis (reflux, chemical, infective, traumatic)
- Stomach: gastritis, reactive gastropathy, or peptic ulcer (infectious, medications, autoimmune, stress, trauma), foreign body ingestion/bezoar, pyloric stenosis
- Small intestine: duodenal ulcer, small bowel volvulus*
- Spleen: infarction, rupture*
- Functional dyspepsia
Name causal conditions of acute abdominal pain in pediatrics: Lower/Hypogastric (5)
- Intestinal: gastroenteritis, constipation, appendicitis/Meckel diverticulitis causing focal peritonitis,* IBD
- Mesenteric lymphadenitis
- Urinary tract: UTI/pyelonephritis, urolithiasis
- Male genital: incarcerated inguinal hernia,* testicular torsion*
- Gynecologic: ectopic pregnancy,* threatened abortion, pelvic inflammatory disease, ovarian torsion,* endometriosis, dysmenorrhea, Mittelschmerz, hematocolpos
Name causal conditions of acute abdominal pain in pediatrics: Generalized or Periumbilical (8)
- Intestinal
- Inflammatory: infectious gastroenteritis, appendicitis,* Meckel diverticulitis,* allergy, IBD, Henoch-Schonlein Purpura (HSP), Hirschsprung, or necrotizing enterocolitis*
- Obstruction*/dysmotility: constipation, Hirschsprung disease (HD), intussusception, malrotation with volvulus, meconium ileus, distal intestinal obstruction syndrome (DIOS), appendicitis, Meckel diverticulitis, adhesions, duodenal/intes- tinal atresia, bezoar/foreign body, strictures
- Malabsorption: secondary lactase deficiency, dietary protein-induced enteropathy/ enterocolitis
- Peritoneal*: abdo trauma, ruptured viscus, primary/secondary bacterial peritonitis, autoinflammatory disease (e.g., Familial Mediterranean fever)
- Metabolic*: diabetic ketoacidosis, hypoglycemia, adrenal insufficiency
- Hematologic: sickle cell acute pain crisis, hemolytic uremic syndrome
- Drugs/toxins*:many (e.g.,consider lead/iron poisoning, salicylates, acetaminophen)
- Referred: pneumonia, pharyngitis, myocarditis/pericarditis
- Infantile colic
- Functional abdo pain, irritable bowel syndrome, abdo migraine
Name causal conditions of CHRONIC abdominal pain in pediatrics: Upper/Epigastric (6)
- Esophagus: esophagitis (reflux, immunologic, infectious, systemic disease associated)
- Stomach: gastritis, reactive gastropathy, peptic ulcer (infections, medications, eosinophilic, immune-mediated), bezoar or foreign body
- Duodenum: peptic ulcer, inflammation (celiac disease, eosinophilic gastroenteritis)
- Hepatobiliary: biliary dyskinesia, chronic hepatitis, cholelithiasis, choledochal cyst
- Pancreatic: chronic pancreatitis, pancreatic pseudocyst
- Functional dyspepsia
Name causal conditions of CHRONIC abdominal pain in pediatrics: Lower/Hypogastric (4)
- Intestinal: gastroenteritis, constipation, IBD, malabsorption, polyps
- Functional abdo pain, irritable bowel syndrome
- Gynecologic: pelvic inflammatory disease, endometriosis
- Urinary tract: ureter pelvic junction obstruction, hydronephrosis, nephrolithiasis
Name causal conditions of CHRONIC abdominal pain in pediatrics: Generalized or Periumbilical (7)
- Inflammatory: IBD, infectious gastroenteritis (parasites, bacteria, viruses), celiac disease, allergy (eosinophilic gastroenteritis, food protein intolerance), collagen
- Intestinal vascular disease
- Obstruction/dysmotility: functional constipation, secondary constipation (HD, anorectal malformation, spinal cord abnormalities, etc.), strictures, malrotation (intermittent volvulus), intussusception
- Malabsorption: carbohydrate intolerance (primary lactase deficiency, overfeed- ing or dietary excess of fermentable oligosaccharides, fructose, sorbitol, etc.), cystic fibrosis
- Metabolic: adrenal insufficiency, diabetes mellitus, thyroid disease
- Hematologic: hereditary angioedema, porphyria
- MSK: muscle strain
- Neoplastic/anatomic: abdo mass (nephroblastoma, neuroblastoma, germ cell tumor, etc.), GI duplication, polyps, hernias (diaphragmatic, internal, umbilical, inguinal), malrotation (Ladd bands)
- Functional abdo pain, irritable bowel syndrome, abdo migraine
Describe HX: Abdominal Pain in Pediatrics (10)
- ID: Age, PMHx, presenting symptoms
- History of Present Illness: Tailor to age of presentation, acuity, and whether appears stable or unstable
- Features of pain: OPQRST
- Provocation by: movement (peritoneal irritation), meal (pancreatitis, cholecystitis, gastric ulcer, GERD)
- Palliation by: emesis (small bowel involvement), defecation (colonic condition), meal (duodenal ulcer)
- Associated symptoms: fever, weight loss
- GI: anorexia, dysphagia, heartburn, vomiting (coffee ground), early satiety, diarrhoea or constipation, last BM, melena, hematochezia, urgency/tenesmus, flatus/ bloating/distension, jaundice
- GU: dysuria, hematuria, polyuria, frequency/nocturia, scrotal pain, vaginal discharge/bleeding, and last menstrual period (normal/abnormal)
- Recent trauma, infections, treatments (and effects)
- Infectious risks: travel Hx, infectious contacts/animal exposures, uncooked food, untreated water
- Past Medical History/PSHx
- If presentation in newborn/infancy—antenatal/perinatal/neonatal Hx, including age (hours/days) of first meconium
- Chronic medical conditions (e.g., sickle cell disease, diabetes mellitus, cystic fibrosis)
- Previous abdo surgeries (risk for adhesions, anastomotic complications)
- Medications/Allergies/Immunizations
- Including OTC medications, alternative medicine
- Nutrition
- Acute pain: time of last meal, relation to pain
- Chronic pain: variety, quantity, maladaptive eating habits, relation to pain (food diary)
- FHx /SHx
- FHx of IBD, celiac disease, functional bowel disorders, etc.
- Adolescents—HEEADDSSS Hx (Home, Education, Employment, Activities, Drugs, Diet, Sexuality, Safety, Suicidal ideation/mood)
- Impacts on daily function (school absenteeism, activities, etc.) and family unit
- Review of Systems: Extraintestinal symptoms of organic disease
Name causal conditions of abdominal pain in paediatrics according to the age of onset (Figure)
Name redflags for an organic pathology (4)
- Pain features: progressive, localized (nonumbilical), wakes from sleep, radiates to shoulder, back, or groin
- GI sx: dysphagia/odynophagia, anorexia, emesis (bilious, bloody, persis- tent), jaundice, absence of flatus/bowel movements, diarrhea (especially chronic and nocturnal), hematochezia/melena
- Extraintestinal sx: unexplained fevers, weight loss/failure to thrive, decelerated linear growth velocity, oral ulcers, perirectal disease, arthritis, cough/dyspnea, dysuria/hematuria, vaginal discharge/bleeding, scrotal/ pelvic pain
- FHx: IBD, celiac disease, peptic ulcer disease
Describe physical exam: Abdominal pain (9)
- General appearance: comfort, positioning, level of consciousness, ill-appearance, malnutrition
- Vitals/anthropometrics: abnormal growth parameters (failure to thrive), fever, tachypnea/desaturation, hypotension, or unexplained tachycardia
- Skin: bruising, petechiae/purpura, jaundice, erythema nodosum, dermatitis her- petiformis, etc.
- HEENT/respiratory: conjunctivitis/episcleritis, oral lesions, cheilitis/glossitis, pharyngeal erythema/exudate, lymphadenopathy, thyromegaly, findings consistent with respiratory infection
- Cardiovascular: delayed capillary refill, diminished peripheral pulses, muffled/ additional heart sounds
- Abdo exam: surgical scars, distention, visible bowel loops, altered bowel sounds, focal tenderness, peritoneal irritation (percussive or rebound tenderness, involun- tary guarding), masses, hepatosplenomegaly, ascites
- DRE: local tenderness, mass, hard stool, blood
- Perianal/GU: perianal skin tag/abscess, hemorrhoids, anal fissure, imperforate anus, scrotal swelling, incarcerated hernia
- Pelvic exam: in sexually active females with lower abdo pain
Describe ROUTINE investigations: Abdominal pain (1)
No additional evaluation required for children with abdo pain who are otherwise healthy, with normal physical exam and absence of “red flags” for organic disease
Name LAB tests: Abdominal pain (11)
- CBC/differential: high WBC/Plt (infectious/inflammatory), anemia (MAHA, hemoglobinopathy)
- Serum electrolytes, glucose, creatinine, BUN (metabolic acidosis, DKA, renal pathology, or hypovolemia)
- Total/direct bilirubin, transaminases, GGT, ALP, amylase, lipase (hepatic, biliary, pancreatic pathology)
- Antitissue transglutaminase and IgA level (celiac disease screen)
- Serum/urine b-hCG (if postmenarcheal female)
- Stool for O&P × 3, C&S, C. difficile PCR, viral culture/electron microscopy
- Consider stool for fecal fat, occult blood, WBC, reducing substances
- Urine R+ M , C+ S if indicated
- Throat swab for culture (streptococcal pharyngitis)
- Urea breath test or stool H. pylori antigen assay (H. pylori screen)
- Consider vaginal swabs or urine testing for chlamydia, gonorrhea, trichomonas (if microscopy available)
Name imaging tests: Abdominal pain (6)
- CXR: pulmonary disease, cardiomegaly (myocarditis), foreign body
- AXR (three views include upright view with visible diaphragms): free air under diaphragm (pneumoperitoneum with ruptured viscus), bowel obstruction/volvulus, nephrolithiasis, constipation, foreign body
- CT abdo (appendicitis, pancreatitis, intra-abdo abscess, mesenteric ischemia, Abdo mass)
- U/S abdo (cholelithiasis, cholecystitis, intussusception, appendicitis, hydronephrosis, obstruction)
- U/S bowel wall or MR enterography (if suspect IBD with small bowel involvement—unable to be determined on upper endoscopy or colonoscopy)
- U/S pelvis/scrotum (testicular torsion, gynecologic pathology)
Name mainly clinical dx (6)
- Henoch-Schönlein Purpura
- Appendicitis
- Infantile colic
- Incarcerated hernia,
- Gastroenteritis
- GERD
Describe HX and Physical exam: Hirschsprung Disease (6)
- HX:
- Delayed meconium
- Failure to Thrive
- Bilious vomiting
- Chronic constipation since birth
- Physical exam:
- Abdo distension
- Digital Rectal Exam: tight anal sphincter, empty ampulla, blast sign (expulsion of gas and stool after DRE)
Describe investigations: Hirschsprung Disease (2)
- Barium enema:
- narrow/normal rectum
- dilated colon proximal to aganglionic segment
- with transition zone
- Definitive Dx by rectal biopsy: absence of ganglion cells
Describe HX (4) and physical exam (2): Pyloric stenosis
- HX:
- Symptom onset 3–8 wk old
- Failure to Thrive, “hungry vomiter”
- M>F
- Projectile nonbilious vomiting, immediately postprandial
- Physical exam:
- ± Visible peristalsis
- Possible palpable epigastric mass (“olive sign”)
Describe investigations: Pyloric stenosis (2)
- U/S: hypertrophied pylorus (increased muscle thickness and length)
- Lytes/blood gas: hypochloremic, hypokalemic metabolic alkalosis
Describe HX (1) and physical exam (2): Duodenal atresia
- HX: Bilious vomiting within hours of birth (later if stenosis)
- Physical exam:
- Epigastric distension
- 1⁄4 have trisomy 21
Describe investigations: Duodenal atresia (2)
- AXR: “double bubble” sign, absent distal abdo gas
- Upper GI series: duodenal obstruction
Describe HX (3) and physical exam (1): Infantile colic
- HX:
- Unexplained paroxysms of irritability, fussiness, or crying starting/ stopping without obvious cause, in < 4 mo old
- episodes of ≥ 3 h/d, ≥ 3 d/wk, for ≥ 1 wk
- No failure to thrive
- Physical exam: Healthy appearing infant
Describe investigations: Infantile colic (1)
Clinical Dx (Rome III criteria)
Describe HX (9) and physical exam (2): Gastroesophageal reflux/GERD
- HX:
- Regurgitation/emesis
- feeding aversion
- “colicky baby,”
- irritable
- Apnea
- stridor
- aspiration
- wheeze
- Sandifer syndrome: back arching, chin lifting, neck contortions due to discomfort
- Physical exam:
- ± FTT (in GERD)
- ± Hoarseness/stridor/wheeze
Describe investigations: Gastroesophageal reflux/GERD (4)
- Empiric trial of acid suppressant
- Endoscopy: esophagitis
- 24- ph probe/impedanc study: acidic/nonacidic reflux, strength of association with suspected signs/ symptoms
- ± Upper GI series: R/O obstruction/stenosis, malrotation
Describe HX (4) and physical exam (4): Incarcerated inguinal hernia
- HX: Classic Hx
- swelling in inguinal area during crying/straining
- Irritable and crying
- Vomiting, abdo distension
- Groin pain
- Physical exam:
- Firm, tender, often edematous inguinal mass
- ± Surrounding erythema
- ± Abdo distension/tenderness
- ± Scrotum appear blue due to testicular venous congestion
Describe investigations: Incarcerated inguinal hernia (3)
- Clinical
- AXR (may see lower GI obstruction or air bubble in groin)
- U/S
Describe HX (6) and physical exam (3): Intussusception
- HX:
- 3 mo to 3 y.o. (up to 6 y.o.)
- Paroxysmal, severe, crampy abdo pain, inconsolable crying, drawing up legs
- Episodes progress in frequency
- ± Vomiting
- Currant jelly stool (blood/ mucous)
- Initially comfortable/normal behavior between episodes; progressive lethargy
- Physical exam:
- Abdo may be benign vs. variable abdo distension and tenderness
- ± Palpable sausage-shaped RUQ or epigastric mass
- ± Bloody mucus on DRE
Describe investigations: Intussusception (2)
- Air contrast enema: obstruction (filling defect), air fluid levels, absence of gas in RLQ
- U/S: target sign (bowel within bowel), tubular mass
Describe HX (3) and physical exam (2): Malrotation with mid-gut volvulus
- HX:
- Sudden onset bilious emesis, abdo distension, melena
- Septic shock (necrotic bowel and 3rd spacing)
- Children may have episodic abdo pain with vomiting for weeks to years before detection
- Physical exam:
- Abdo distension/tenderness
- ± Peritonitis/shock
Describe investigations: Malrotation with mid- gut volvulus (2)
- AXR: upper GI obstruction (dilated proximal loops with fairly gasless abdo), pneumoperitoneum
- Upper GI series: failure of duodenum to cross midline (malrotation), duo- denal obstruction (volvulus)
Describe HX (8) and physical exam (4): UTI
- HX:
- Dysuria
- urgency
- frequency
- Irritability
- fever
- poor feeding
- Vomiting or diarrhea
- Flank or abdo pain
- Physical exam:
- Tender abdo (suprapubic)
- ± Costovertebral angle tendernes
- Murphy punch sign (in pyelonephritis)
- ± Fever
Describe investigations: UTI (3)
- Urine R&M (WBC, nitrites, leukocyte esterase)
- C&S
- Controversy in workup after 1st UTI: renal U/S ± Voiding Cystourethrogram
Describe HX (4) and physical exam (3): Constipation
- HX:
- BMs: 2 or less per week, large diameter, difficult/incomplete evacuation
- Colicky abdo pain, painful defecation
- ± fecal incontinence
- ± Retentive posturing
- Physical exam:
- Abdo palpation of hard fecal mass
- Dilated rectum filled with stool
- ± Anal fissure
Describe investigations: Constipation (2)
- Clinical (Rome criteria for functional constipation)
- AXR: fecal impaction (excessive stool in colon)