10-23: Cell cycle control and cell division Flashcards
1
Q
Cell cycle control
A
- DNA replication to 2 identical daughter cells
- 3 major checkpoints
- many of the genes (proteins) involved in cell cycle regulation are critical determinants of cancer progression
2
Q
Interphase
A
G1: growth and metabolic
S: replication of DNA
G2: growth and prep
3
Q
Mitosis
A
P: condensed
M: center
A: segregate
T: decondensed
4
Q
Cytokinesis
A
Cell splits (two identical daughter cells)
5
Q
Resting Phase
A
G0
6
Q
G1/S Checkpoint
A
Check for:
Nutrients
Growth factors
DNA damage
7
Q
G2/M Checkpoint
A
Check for:
cell size
DNA replication
8
Q
Metaphase to anaphase checkpoint
A
Check for chromosome spindle attachment
9
Q
Cell cycle checkpoint control system
A
- Dependant on cyclically activated cyclin dependant protein kinases (Cdks)
- dependant on cyclical proteolytic events
- dependant on transcriptional regulation
10
Q
Cell cycle checkpoint control system
A
- Initiates/ends events
- proper order and fidelity
- Intracellular and extracellular dependant
- Arrests the cycle (fails to complete a process or unfavorable conditions)
11
Q
cyclins and cyclin dependant protein kinases
A
- Cdk binds to cyclin
- phosphorylation
- active cyclin Cdk complex
12
Q
Cyclin D
A
Cyclin D
13
Q
Cyclin E
A
G1/S cyclin
14
Q
Cyclin A
A
S cyclin
15
Q
Cyclin B
A
M cyclin