1 - Water and pH Flashcards
Causes of high anion gap metabolic acidosis
MUDPILES
Methanol Uremia Diabetic Ketoacidosis Paraldehyde and Propylene Glycol Isoniazid Lactic acidosis (Sepsis, Shock) Ethylene Glycol Salicylates
Negative logarithm of hydrogen ion concentration
pH
Any substance that resists a change in pH when protons are produced or consumed
Buffer
Chemical compound that has a total net charge of zero
Zwitterion
pH at which the zwitterion is the predominant form of a chemical compound
Isoelectric pH
used to calculate the concentration of a weak acid (HA) and its conjugate base (A-)
Henderson-Hasselbalch equation
If actual pH < pKa substance is
Protonated
Base is charged
Acid is uncharged
If actual pH > pKa substance is
Deprotonated
Electrons that can form hydrogen bonds
SON
Sulfur
Oxygen
Nitrogen
Water molecules have a slight tendency to dissociate and form:
Hydronium (H30) and Hydroxide ions (OH)
Most important EXTRAcellular buffer
Bicarbonate
Most important INTRAcellular buffer
Proteins
This means that water can act both as an acid and a base in a solution
Amphoteric
Bond between a water molecule and another polar compound
Hydrogen Bond
Accepts H+ ions
Base
Donates protons
Acid
pKa below 7
Acid