1 Tuberculosis

Question 1

PPD test, ≥5-mm induration is positive in

Answer 1

CHASO
Patients with
Close contact with TB-infected individual
HIV
Abnormal CXR suggestive of healed TB
Steroid use (immunosuppressed) equivalent of prednisone 15 mg/day for 1 month
Organ transplants

Question 2

PPD test, ≥10 mm induration is positive in patients not meeting the above criteria but who have other risks, such as:

Answer 2

CHIC4

Conditions that increase the risk of progression to active disease (Silicosis, Diabetes, CA of head neck lung)
High-prevalence groups (Immigrants, Locals of high-risk areas, Long term care facility residents)
Injection drug users
Children <4 y/o

Question 3

strongest known risk factor for TB

Answer 3

HIV infection

Question 4

Isoniazid daily dose

Answer 4

5 mg/kg PO
Max 300 mg

Question 5

Rifampin daily dose

Answer 5

10 mg/kg pO
Max 600 mg

Question 6

Pyrazinamide daily dose

Answer 6

15-30 mg/kg PO
Max 2 grams

Question 7

Ethambutol daily dose

Answer 7

15-20 mg/kg PO
Max 1.6 grams

Question 8

thrombocytopenia may rsult from this anti-tb drug

Answer 8

rifampin, rifapentine

Question 9

this anti-tb drug may cause exacerbation of porphyria

Answer 9

rifapentine

Question 10

this anti-tB drug may cause peripheral neuropathy

Answer 10

ethambutol

Question 11

these anti-tb drugs may cause hepatitis

Answer 11

isoniazid
rifampin
rifapentine
rfabutin
pyrazinamide

Question 12

classic miliary tuberculosis shows diffuse nodules on radiographs with diameter of about _________

Answer 12

1-3 mm

Question 13

metabolic abnoramlity that’s a unique finding of immune reconstitution syndrome

Answer 13

Hypercalcemia

Question 14

Immune reconstitution syndrome is more commonly seen in

Answer 14

TB patients and those with HIV infection, specifically with CD4 ≤50 cells/mm3

Findings in Immune reconstitution syndrome include:
fever
worsening respiratory status and pulmonary infiltrates
lymphadenopathy
hepatosplenomegaly
ascites
meningitis
new or worsening CNS lesions
hypercalcemia