1. The Oral Cavity Flashcards

1
Q

What are the general histological features/features of the oral cavity? What kind of epithelium?

A
STRATIFIED SQUAMOUS EPITHELIUM
Lips
Rest of oral cavity- minor salivary glands (seromucous glands)
Teeth
Tongue
Major Salivary Glands
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2
Q

What is the difference between the lip, vermillion border and the tongue?

A

The LIP:

  • Hair follicles
  • Stratified squamous KERATINISED epithelium

VERMILLION BORDER

  • No glands
  • No hair follicles
  • Blood vessels

TONGUE

  • Statified squamous NON KERATINISED epithelium; this is normally not keratinised but can become para keratinised with excessive wear and tear.
  • Skeletal muscle arranged at right angles
  • Numerous seromucous glands are often embedded between the muscle fibres.
  • Skeletal muscle - orbicularis oris.
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3
Q

What is the histological difference bewtween the anterior 1/3 and posterior 1/3 of the tongue?

A

Anterior 1/3 lacks the MALT thatthe posterior 1/3 is famous for.

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4
Q

What are the papillae on the surface of the tongue?

What separates anterior 2/3 from posterior 1/3?

A

Anterior to posterior:

  • Filiform papillae
  • Fungiform
  • Foliate
  • Circumvillate

The ANTERIOR 2/3 of the tongue is separated fromt he posterior third by the SULCUS TERMINALIS- which is where the circumvillae papillae lie

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5
Q

Which papillae are Gutatory?

A

Circumvallate, Foliate, Fungiform

Circumvillate: V shaped line of around 9 (4-18) papillae anterior ot the sulcus terminalis
They contain about half of all taste buds
Von Ebners Glands associated with them and the FOliate Papillae - (serous only)
Supplied by CN9 (glossopharyngeal n)

Foliate:
Found bilaterally along posterolateral margins of the tongue
Contain about 1/4 of all tast buds
Supplied by CN9, and CN12 (hypoglossal)

Fungiform:
Found over most of the surface. Contain 1/4 of tast buds (some may contain no taste buds at all). Supplied by CN9, CN12.

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6
Q

Taste Buds

What are the 5 modalities to human taste perception?

A

Gustatory Papillae: circumvillate, fungiform & Foliate

There are 5 modalities to human taste perception:

  1. Sour
  2. Salt
  3. Bitterness
  4. Sweetness
  5. Imami - monosodium glutamate.

All taste buds have a similar structure, with taste receptor cells having a lifespan of only around 10 days before being replaced (olfactory region 30 days)
Extralingual taste buds can also be found- palate, uvulva, oesopahgus, epiglottus

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7
Q

Which nerve supplies (taste) Posterior 1/3 of tongue?

Which nerve/s supply taste afferents for anterior 2/3 or tongue

Which nerve supplies taste posterior to the pharynx

A
  1. GLOSSOPHARYNGEAL CN9
  2. CN 7
  3. CNX (vagus)
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8
Q

Explain the structure and function of Von Ebners Glands

A

Found at the base of the circumvallate and foliate papillae crypts.

They are SEROUS secreting minor salivary glands that produce lingual lipase.

Their secretion also helps to act as the liquid milieu in which taste can be detected.

Important in washing away taste molecules so new taste can be detected

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9
Q

What are the embryological structures from which teeth are derived?

A

ENAMEL/ DENTAL LAMINA: from ECTODERM

Dentin, cemetum, pulp and periodontal ligament from the MESODERM (mesenchyme)

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10
Q

Explain the development of a TOOTH!!

A

The DENTAL LAMINA (4 of these) appears at 6 WEEKS

Each DENTAL LAMINA gives rise initially to 4 ENAMEL ORGANS (enamil organs will develop into central and lateral incisors, the canines and the first molar teeth- all deciduous)

The enamel organ develops an epithelial layer of enamel producing cells - AMELOBLASTS

Later in development the DENTAL LAMINA will develop posteriorly and give rise to further enamel organs for the rest of the molar teeth (one more deciduous molar and the 3 permanent molars)

The deciduous teeth are eventually lost and replaced by permanent teeth which develop adjacent to the deciduous ones.

The MESENCHYME immediately adjacent to he enamel organ condenses to form the DENTAL PAPILLA. This stage (because of its shape) is called the CAP STAGE

The dental papilla develops a layer of DENTIN producing cells called ODONTOBLASTS

As the enamel organ develops further it assumes a shape which is referred to as the bell shape. At this stage the formation of the dentine and then enamel, has begun between the two epithelial layers.

Tooth eruption is caused by growth (elongation of th tooth)

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11
Q

Explain the structure of the mature tooth!

A

Enamel; Dentin; Odontoplasts (still present); dentin

Crown; Neck and Root.

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12
Q

ODONTOBLASTS- the cell

A

A DENTINAL TUBULE- contains the odontoblast apical process. Walls of the tubule are formed by alligned collagen fibres. At the end of the tubule, the bifurcated end extends into the enamel.

DENTIN consists of 2-% organic material (mainly TYPE I COLLAGEN) and 80% inorganic material (cyrstals of hydroxyaatitie and fluoroapatite)

PREDENTIN is the non mineralised zone surrounding the apical processes of the odontoblast. It contains type I collagen resulting from the released procollagen processed into tropocollagen.

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13
Q

Ameloblasts the cell

A

blar

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14
Q

What is Amelogenesis Imperfecta?

A

No or imperfect formation of enamel during tooth development
- 3 main genes identified, depending o nthe gene, may demonstrate autosomal dominant or autosomal recessive or X-linked inheritance

  • Teeth are unusually small, discoloured, pitted or grooved nd prone to rapid wear and breakage.
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15
Q

Salivary Glands- what are the salivary glands emptying into the mouth via ducts?

A

Parotid Salivary Glands: Serous secretion- anterior to ears, empties near upper teath

SUBMANDIBULAR Salivary Glands: 80% serous, 20% mucous

SUBLINGUAL Salivary Glands: 80% mucous

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16
Q

What are the 4 major components of Saliva?

A
  • Mucins : lubricant, cytoprotection from microorganisms
  • Amylase : Initiates digestion of startch
  • Lingual Lipase: Slightly alkaline electrolyte solution. Moistens food, neutralises acids in the oesophagus. Contains other components such as lysozyme, lactoferrin, IgA plus others
17
Q

What are the functions of Saliva?

A

Protective: tissue coating, lubrication, humidification, taste

  • Host Defence: immunological, antibacterial, antiviral, antifungal
  • Digestion: Digestive enzymes, taste, bolus formation
18
Q

What is the histology of Salivary Glands

A

Glands are arranged as numerous ACINI which are drained by a duct system

Glands can be described as serous, mucous or mucoserous (seromucous) depending on the product secreted. In mixed glands, the serous component may exist as SEROUS DEMILUMES

An acinus (acini plural) is a spherical arrangement of secretory cells within the gland
- All the cells of an acinus secrete into a central lumen which becomes an intercalated duct.

MYOEPITHELIAL CELLS are often associated with the secretory cells within the basement membrane of the acinus. Their contraction aids expression of the secretory product.

19
Q

Parotid Salivary Gland

A

100% serous- look for acini and striated ducts

EM : round nucleus and the apical cytoplasm filled with secretory granules. This appearance is typical of any serous secreting gland (pancreas, parotid, peptic cell of the stomach etc).

20
Q

Submandibular Salivary Gland

A

SEROUS 80%, Mucous 20%
Mostly serous acini with some mucous acini displaying serous demilumes.

Note that the MA the nucleus are flattened and pushed to the base of the cell. The cytoplasm is very pale staining with H& E.

21
Q

Sublingual Salivary Gland

A

80% Mucous

Mostly mucous acini with serous secreting cells only present as serous demilumes

22
Q

Ducts

A

The ducts CONDUCT and MODIFY the secretory product.

All large glands can be described as having a number of lobes. So there are intralobular (within lobes) and interlobular (between lobes) ducts.

The lumen of the secretory acinus is continuous with that of the duct system. The intralobular ducts include intercalated ducts and striated ducts both of which are capable of modifying the secretion.

Serous glands have well developed intercalated and striated ducts. Mucous glands do not.
MYOEPITHELIAL CELLS may be associated with the striated ducts.

23
Q

WHat are intercalated Ducts

A

Lined by SIMPLE SQUAMOUS to LOW CUBOIDAL epithelium

  • intralobular ducts
  • Secrete BICARBONATE into the secretion
  • Reabsorb chloride ions from the secretion
24
Q

what are striated ducts

A

Lined by simple tall cuboidal to low columnar epithelium
INTRALOBULAR DUCTS (ie. connects intercalated ducts to interlobular ducts)
Basal and lateral cell membrane infoldings with mitochondria (striations) which reabsorb SODIUM from the secretion

Secrete Potassium and bicarbonate into the secretion
Normally produces a hypotonic alkaline secretion
Elevated secretion can cause a hypertonic secretion.

25
Q

Interlobular (excretory) Ducts

A

Lined by cuboidal or columnar epithelium that it initially simple but may become stratified. Interlobular ducts do not modify excretion

26
Q

How to differentiate Lymphatic Tissues in the oral Cavity:

Palatine Tonisls
Pharyngeal Tonsils
Lingual Tonsile

A

Palatine: stratified squamous epithelium
Pharyngeal Tonsils: Respiratory epithelium
Lingual Tonsils: will see the tongue- stratified squamous

26
Q

How to differentiate Lymphatic Tissues in the oral Cavity:

Palatine Tonisls
Pharyngeal Tonsils
Lingual Tonsile

A

Palatine: stratified squamous epithelium
Pharyngeal Tonsils: Respiratory epithelium
Lingual Tonsils: will see the tongue- stratified squamous