1: Lightning Bolts & Bullseyes #1 Flashcards
all of the starred/highlighted content for exam 1
considerations for squamous cell caricinoma
central lesions (predominantly)
often with endobronchial tumor
mass effects: obstruction, cavitation
considerations for adenocarcinoma
peripheral lesions
extrapulmonary invasion common
most pancoast tumors
growth hormone, corticotropin
hypertrophic osteoarthropathy
considerations for large cell carcinoma
large, cavitating peripheral tumors
similar to adenocarcinoma
considerations for small cell carcinoma
central lesions (predominantly)
surgery usually not indicated
paraneoplastic syndromes
Lambert-Eaton syndrome*
fast growth rate
early metastases
Lambert-Eaton syndrome
- impaired release of acetylcholine from the terminals; lower limb weakness
- sensitive to non-depolarizers and respond poorly to anticholinesterase reversal agents
- may improve after surgery
considerations for carcinoid tumors
proximal, endobronchial
bronchial obstruction with distal pneumonia
highly vascular
benign (predominantly)
no association with smoking
5 year survival > 90%
carcinoid syndrome (rarely)
carcinoid*
severe hypotension may need to use specific antagonists: octreotide or somatostatin
care of the patient on Bleomycin
low FiO2 d/t pulmonary toxicity (avoid hyperoxia)
care of the patient on Cisplatin
NSAIDs contraindicated d/t increased creatinine
4 M’s of Anesthetic considerations in lung cancer patients
- Mass effects
- Metabolic effects
- Metastases
- Medications
mass effects of lung cancer
obstructive pneumonia, LUNG ABSCESS, SVC syndrome, tracheobronchial distortion, pancoast syndrome, recurrent laryngeal nerve or phrenic nerve paresis, chest wall or mediastinal excision
metabolic effects of lung cancer
Lambert-Eaton syndrome, HYPERCALCEMIA, HYPONATREMIA, cushing’s
metastases effects of lung cancer
particularly to bone, brain, liver, and adrenal
medication considerations for lung cancer patients
Bleomycin, mitomycin: pulmonary toxicity
Doxorubicin: cardiac toxicity
Cisplatin: renal toxicity
of the lung cancer considerations, which are the most detrimental?
mass effects
Preop Lung Function: what is the 80-40-15 rule?
FEV1 > 80% (no testing needed)
PPO FEV1 DLCO < 40% (increased risk, exercise test)
VO2 Max < 15 mL/kg/min (increased risk)
most valid test for respiratory mechanical function
FEV1
most valid test for lung parenchymal function
DLCO
most valid test for caridopulmonary interaction
maximal oxygen consumption (VO2)
ABG CO2 > 45 mm Hg
indicator of poor ventilatory function
SaO2 < 90%
preop hypoxemia
albumin < 3.6 and BUN > 22
important predictor of pulmonary complications
renal function and nephrotoxic drugs
methotrexate & cisplatin
what is a more reliable indicator of poor outcomes with thoracic surgery?
desaturation with exercise